| Project/Area Number |
20591886
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SASAKI Shoichi Nagoya City University, 大学院・医学研究科, 准教授 (50225869)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yasue 名古屋市立大学, 大学院・医学研究科, 講師 (00381830)
KOJIMA Yoshiyuki 名古屋市立大学, 大学院・医学研究科, 講師 (60305539)
OKADA Shinsuke 名古屋市立大学, 大学院・医学研究科, 研究員 (40381818)
TAKADA Masa 名古屋市立大学, 大学院・医学研究科, 研究員 (60468254)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | KIT陽性間質細胞 / 細胞増殖 / Glivec / Bcr-Abl / マウス / BOO(膀胱流出路閉塞)モデル / 過活動膀胱 / KIT変異ラット / サイクロフォスファミド / ラット / SCF / Bcr-Ab1 |
|---|
| Research Abstract |
KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Research into the effect of c-kit receptor inhibitor, imatinib mesylate, on bladder function implies that KIT-positive ICCs may be therapeutic target cells to reduce bladder overactivity and that the blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment.
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