Research for signal mechanism of the KIT-positive interstitial cells and development of the new molecular target treatment for the over active bladder
| Project/Area Number |
20591886
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SASAKI Shoichi Nagoya City University, 大学院・医学研究科, 准教授 (50225869)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Yasue 名古屋市立大学, 大学院・医学研究科, 講師 (00381830)
KOJIMA Yoshiyuki 名古屋市立大学, 大学院・医学研究科, 講師 (60305539)
OKADA Shinsuke 名古屋市立大学, 大学院・医学研究科, 研究員 (40381818)
TAKADA Masa 名古屋市立大学, 大学院・医学研究科, 研究員 (60468254)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | KIT陽性間質細胞 / 細胞増殖 / Glivec / Bcr-Abl / マウス / BOO(膀胱流出路閉塞)モデル / 過活動膀胱 / KIT変異ラット / サイクロフォスファミド / ラット / SCF / Bcr-Ab1 |
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| Research Abstract |
KIT is not only a detection marker of these cells, but also may play a crucial role in the control of bladder function. Research into the effect of c-kit receptor inhibitor, imatinib mesylate, on bladder function implies that KIT-positive ICCs may be therapeutic target cells to reduce bladder overactivity and that the blockage of c-kit receptor may offer a new therapeutic strategy for OAB treatment.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats.2011
Author(s)
Shibata Yasuhiro, Ugawa Shinya, Imura Makoto, Kubota Yasue, Ueda Takashi, Kojima Yoshiyuki, Ishida Yusuke, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Shimada Shoichi
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Journal Title
NeuroReport 185
Pages: 1053-1057
Related Report
Peer Reviewed
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[Journal Article] TRPM8-expressing dorsal root ganglion neurons project dichotomizing axons to both skin and bladder in rats.2011
Author(s)
Shibata Yasuhiro, Ugawa Shinya, Imura Makoto, Kubota Yasue, Ueda Takashi, Kojima Yoshiyuki, Ishida Yusuke, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Shimada Shoichi
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Journal Title
NeuroReport
Volume: 185
Pages: 1053-1057
Related Report
Peer Reviewed
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[Presentation] Convergence of bladder and skin primary sensory neuron expressing TRPM82010
Author(s)
Shibata Yasuhiro, Kojima Yoshiyuki, Hamakawa Takashi, Imura Makoto, Hayase Mass, Kubota Yasue, Uada T, Sasaki Shoichi, Ugawa S, Kohri Kenjiro
Organizer
Annual Meeting of the International Continence Society
Place of Presentation
Metro Toronto Convention Centre, Toronto(Canada)
Related Report
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[Presentation] cyclophosphamide 誘発膀胱炎モデルラットにおけるKIT陽性間質細胞の役割2009
Author(s)
岡田真介, 小島祥敬, 濱川隆, 伊藤尊一郎, 柴田泰宏, 井村誠, 早瀬麻沙, 窪田泰江, 佐々木昌一, 津ヶ谷正行, 郡健二郎
Organizer
第97回日本泌尿器科学会総会
Place of Presentation
岡山コンベンションセンター(岡山市)
Related Report
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[Presentation] 卵巣摘除ラットの排尿状態におけるisoflavone投与の影響2008
Author(s)
岡田真介, 小島祥敬, 濱川隆, 伊藤尊一郎, 柴田泰宏, 井村誠, 早瀬麻沙, 濱本周造, 水野健太郎, 窪田泰江, 佐々木昌一, 津ヶ谷正行, 郡健二郎
Organizer
第58回日本泌尿器科学会中部総会
Place of Presentation
大津市
Year and Date
2008-11-15
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