| Project/Area Number |
20591977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Shinshu University |
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Principal Investigator |
TAKUMI Yutaka Shinshu University, 医学部, 准教授 (70312501)
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| Co-Investigator(Renkei-kenkyūsha) |
USAMI Shinichi 信州大学, 医学部, 教授 (10184996)
SUZUKI Nobuyoshi 信州大学, 医学部附属病院, 助教 (20377641)
HASHIMOTO Shigenari 信州大学, 医学部・附属病院, 助教(特定雇用) (90359729)
NISHIO Shinya 信州大学, 医学部, 研究員 (70467166)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 耳科学 / 細胞外マトリクス / 難聴遺伝子 / 蓋膜 / 血管条 / ラセン靭帯 / 難聴 / 細胞外基質 / コラーゲン / RNA / 発現解析 / マウス / バリアント / 内耳 / 遺伝子 / 感音難聴 / 細胞外マトリックス / レーザーマイクロダイセクション / 電子顕微鏡 |
|---|
| Research Abstract |
In Extra cellular matrix, many kind of collagen are contained and some species of them are reported as a responsible gene for deafness causing. In this study, we analyzed all kinds of collagen genes expression levels of inner ear and whole body. As a result, 13 collagen gene expressed twice or more in inner ear than whole body, And 6 collagen gene expressed 10 fold or more. These genes might be good candidates for new deafness causing genes.
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