| Project/Area Number |
20591987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kochi University |
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Principal Investigator |
TAKEDA Taizo (2008, 2010) Kochi University, 名誉教授 (50115763)
竹田 泰三 (2009) Kochi University, 名誉教授 (50115705)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIOKA Rie 高知大学, 教育研究部・医療学系, 助教 (20398051)
KAKIGI Akinobu 東京大学, 医学部, 講師 (60243820)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | aquaporin / イオン共輸送体 / 血管条 / 内リンパ嚢 / vasopressin / 水チャネル / NKCC1 / NKCC2 / stria vascularis / endolymphatic sac / bumetanide / 内耳水代謝 |
|---|
| Research Abstract |
The expressions of many subtypes of aquaporins (AQP) including AQP-2, vasopressin type 2 receptor, and NKCC1 were molecular biologically and immunohistochemically evaluated. Since the application of vasopressin, bumetanide, and OPC-31260 exerted the morphological influence on the intrastrial space, AQP2-vasopressin mediated water transport and water flow through the Na-K-Cl co-transporter might work actively in the inner ear fluid homeostasis.
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