Gene therapy targeting HPV oncogenes against head and neck cancer
| Project/Area Number |
20592016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kobe University |
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Principal Investigator |
OTSUKI Naoki Kobe University, 大学院・医学研究科, 准教授 (40343264)
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| Co-Investigator(Kenkyū-buntansha) |
NIBU Kenichi 神戸大学, 医学研究科, 教授 (20251283)
SHIRAKAWA Toshiro 神戸大学, 医学部, 准教授 (70335446)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 頭頸部がん / 遺伝子治療 / ヒト乳頭腫ウイルス / 頭頸部癌 |
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| Research Abstract |
Introduction of HPV16 E6/E7 siRNA might be a potentially potent and specific approach, to inhibit proliferation and induce apoptosis of HNSCC containing HPV16 cell lines. For clinical we are currently preparing to test the effects of HPV16 E6/E7 siRNA on xenograft of HNSCC containing HPV16 cell lines
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Report
(4 results)
Research Products
(30 results)
