Diabetic retinopathy (DMR)and Vasohibin
| Project/Area Number |
20592030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
ISHIKAWA YUMI Tohoku University, 大学院・医学系・研究科, 技術補佐員 (60396439)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Toshiaki 東北大学, 大学院・医学系研究科, 教授 (90191858)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | バゾヒビン / 糖尿病 / 網膜症 / 血漿 / 血管内皮細胞増殖因子(VEGF) / HIF / バソヒビン |
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| Research Abstract |
I examined vasohibin whether or not it works as marker for treatment of diabetic retinopathy (DMR) or as the possibility of new drug. Vasohibin in plasma was not correlated with retinopathy, however it was lower as the stronger the retinopathy. Retinal pigment epithelial cell transduced with HRE-directed EGFP expression vector showed positive correlation between VEGF and EGFP expression when I added intra-ocular fluids of patients in the medium. Patients with DMR had some factors that induced HIF.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone.2011
Author(s)
Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
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Journal Title
J Control Release. 151(1)
Pages: 65-73
Related Report
Peer Reviewed
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[Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor2011
Author(s)
Ryosuke Wakusawa, Toshiaki Abe, Hajime Sato, Hikaru Sonoda, Masaaki Sato, Yuuichi Mitsuda, Tomoaki Takakura, Tomi Fukushima, Hideyuki Onami, Nobuhiro Nagai, Yumi Ishikawa, et al
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Journal Title
Invest Ophthalmol Vis Sci Feb 23
Related Report
Peer Reviewed
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[Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor2011
Author(s)
Ryosuke Wakusawa, Toshiaki Abe, Hajune Sato, Hikaru Sonoda, Masaaki Sato, Yuuichi Mitsuda, Tomoaki Takakura, Tomi Fukushima, Hideyuki Onami, Nobuhiro Nagai, Yumi Ishikawa, et al
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 未定(in press)
Related Report
Peer Reviewed
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[Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone.2010
Author(s)
Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
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Journal Title
J Control Release. Dec 2.(Epub ahead of print)
Related Report
Peer Reviewed
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