Studies on the pathogenesis and development of pharmacological treatment of retinopathy of prematurity
| Project/Area Number |
20592041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
KUSAKA Shunji Osaka University, 医学部附属病院, 教授 (60260387)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Yuske 大阪大学, 大学院・医学系研究科, 助教 (20362717)
FUJIKADO Takashi 大阪大学, 大学院・医学系研究科, 教授 (50243233)
西信 良嗣 大阪大学, 医学系研究科, 助教 (30379193)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 未熟児網膜症 / 新生血管 / DNAアレイ / 薬物療法 / サイトカイン |
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| Research Abstract |
Gene expression profiles of oxygen-induced retinopathy and control mice were investigated using real-time PCR. Upregulation of genes associated with inflammation were observed 2 days before the development of neovascularization (NV), and continued until a few days after disappearance of NV. On the other hand, upregulation of genes associated with NV, such as vascular endothelial growth factor and angiopoietin-2, were observed from one day before the development of NV until the disappearance of NV.
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Report
(4 results)
Research Products
(89 results)
