| Project/Area Number |
20592092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Nihon University |
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Principal Investigator |
IKEDA Taro (2009-2010) Nihon University, 医学部, 助教 (00318396)
草深 竹志 (2008) Nihon University, 医学部, 教授 (70263267)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITO Kiminobu 日本大学, 医学部, 助教 (10328750)
NAGASE Hiroki 日本大学, 医学部, 客員教授 (90322073)
FURUYA Takeshi 日本大学, 医学部, 専修医 (20568539)
池田 太郎 日本大学, 医学部, 助教 (00318396)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小児固形腫瘍 / DNAメチル化 / 癌関連遺伝子 / MassARRAY / MassARRAY epiTYPER法 / MassARRAY epityper法 |
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| Research Abstract |
We have identified that at least four (SLC16A、ZNF206、NR4A3、ZAR-1) out of 12 tDMRs showed frequent aberrant methylation in pediatric solid tumors. The methylation of these four genes confers novel candidate pediatric solid tumors-related epigenetic factors. SLC16A, ZNF206, and NR4A3 genes were related to the prognosis in neuroblastoma. Hypermethylation of the ZAR-1 non-promoter is extremely frequent in hepatoblastoma, and ZAR-1 expression plays a tumorigenic role. The pathway of these four genes was different. It could be useful the treatment of children with pediatric solid tumors to analyze the methylation level of four genes (SLC16A、ZNF206、NR4A3、ZAR-1).
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