New procedure of evaluation of molecular mechanism in skin cancer : adequate diagnosis and reconstruction.

Research Project

Project/Area Number	20592099
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Plastic surgery
Research Institution	Ehime University
Principal Investigator	MORI Hideki Ehime University, 医学部附属病院, 助教 (60325389)
Co-Investigator(Kenkyū-buntansha)	HIRAKAWA Satoshi 愛媛大学, 医学部附属病院, 講師 (50419511)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	リンパ管新生 / Paget病 / 乳房外Paget病 / 血管・リンパ管新生
Research Abstract	In extramammary Paget disease(EMPD), lymphangiogenesis appeared in a early stage. We found that Paget cells adopt an invasive phenotype during epithelial-mesenchymal transition (EMT) seen in tumor progression. We found that invasive Paget cells in patient N-cadherin, a mesenchymal marker indicative of EMT, suggesting a molecular mechanism underlying tumour invasion. EMT is reportedly required for invasive phenotypes of tumour cells of epithelial origin, including EMPD.

Report

(4 results)