In vivo patch-clamp analysis of plastic changes in descending inhibitory system

• Project/Area Number: 20602003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Kyushu University
• Principal Investigator: FURUE Hidemasa Kyushu University, 生体情報研究系, 准教授 (20304884)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Megumu 九州大学, 医学研究院, 教授 (10140641)
• Co-Investigator(Renkei-kenkyūsha): YOSHIMURA Megumu 熊本保健科学大学, 保健科学部, 教授 (10140641)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: シナプス / 感覚 / ノルアドレナリン / 鎮痛 / 青斑核 / 下行性痛覚抑制 / in vivoパッチクランプ / 神経回路 / ニューロン / 痛覚 / EPSC / IPSC / 膠様質

Research Abstract

Descending noxious inhibitory system was studied by using in vivo patch-clamp recording technique. The present main finding is that stimulating the locus coeruleus enhances spinal inhibitory synaptic transmission.

Research Products

• [Journal Article] In vivo patch-clamp analysis of descending noradrenergic controls of spinal nociceptive transmission. (2011)
  • Author(s): Sugiyama D, Imoto K, Kawamata M, Furue H.
  • Journal Title: Pain Research (in press)
  • Peer Reviewed
• [Journal Article] In vivo patch-clamp analysis of descending noradrenerdic controls of spinal nociceptive transmission. (2011)
  • Author(s): Sugiyama D, et al.
  • Journal Title: Pain Research Volume: in press
  • Peer Reviewed
• [Journal Article] Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo. (2010)
  • Author(s): Hachisuka J, Furue H, Furue M, Yoshimura M.
  • Journal Title: Journal of Neurophysiology 104(1) Pages: 271-279
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord. (2010)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Uta D, Yamamoto J, Furuse S, Katafuchi T, Imoto K, Iwamoto Y, Yoshimura M.
  • Journal Title: Molecular Pain 6 Pages: 38-38
  • Peer Reviewed
• [Journal Article] 局所麻酔薬光学異性体の痛覚伝達選択的な遮断効果-基礎生理学的な検討- (2010)
  • Author(s): 古江秀昌、歌大介
  • Journal Title: 日本臨床麻酔学会誌 30(4) Pages: 535-544
  • NAID: 10026917429
• [Journal Article] Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons. (2010)
  • Author(s): Georgiev SK, Furue H, Baba H, Kohno T.
  • Journal Title: Molecular Pain 6 Pages: 25-25
  • Peer Reviewed
• [Journal Article] TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substnatia gelatinosa neurons in the adult rat spinal cord. (2010)
  • Author(s): Uta D, Furue H, Pickering AE, Rashid MH, Mizuguchi-Takase H, Katafuchi T, Imoto K, Yoshimura M.
  • Journal Title: European Journal of Neuroscience 31(11) Pages: 1960-1973
  • Peer Reviewed
• [Journal Article] 生理学の立場から光学異性体の末梢神経(後根神経節細胞)への作用の違い (2010)
  • Author(s): 古江秀昌, et al.
  • Journal Title: 日本臨床麻酔学会誌 Volume: 30 Pages: 535-544
  • Peer Reviewed
• [Journal Article] Bone cancer induces a unique central sensitization through synaptic changes in a widearea of the spinal cord. (2010)
  • Author(s): Yanagisawa Y, et al.
  • Journal Title: Molecular Pain Volume: 6
  • Peer Reviewed
• [Journal Article] Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine induced pruritic stimuli in vivo. (2010)
  • Author(s): Hachisuka J, et al.
  • Journal Title: Journal of Neurophysiology Volume: 104 Pages: 271-279
  • Peer Reviewed
• [Journal Article] TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. (2010)
  • Author(s): Uta D, et al.
  • Journal Title: European Journal of Neuroscience Volume: 31 Pages: 1960-1973
  • Peer Reviewed
• [Journal Article] Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal hornneurons. (2010)
  • Author(s): Georgiev SK, et al.
  • Journal Title: Molecular Pain Volume: 6
  • Peer Reviewed
• [Journal Article] TRPAI -expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord (2010)
  • Author(s): Uta D, et al.
  • Journal Title: European Journal of Neuroscience (印刷中)
  • Peer Reviewed
• [Journal Article] Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings. (2009)
  • Author(s): Takazawa T, Furue H, Nishikawa K, Uta D, Takeshima K, Goto F, Yoshimura M.
  • Journal Title: European Journal of Neuroscience 29(3) Pages: 518-529
  • Peer Reviewed
• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. (2009)
  • Author(s): Abe K, Kato G, Katafuchi T, Tamae A, Furue H, Yoshimura M.
  • Journal Title: Neuroscience 159(1) Pages: 316-324
  • Peer Reviewed
• [Journal Article] Actions of propofol on substantia gelatinosa neurons in rat spinal cord revealed by in vitro and in vivo parch-clamp recordings (2009)
  • Author(s): Takazawa T, et al.
  • Journal Title: European Journal of Neuroscience 29 Pages: 518-529
  • Peer Reviewed
• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro (2009)
  • Author(s): Abe K, et al.
  • Journal Title: Neuroscience 159 Pages: 316-324
  • Peer Reviewed
• [Journal Article] Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings. (2009)
  • Author(s): Takazawa T., et al.
  • Journal Title: European Journal of Neuroscience 29(3) Pages: 518-528
  • Peer Reviewed
• [Journal Article] Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro. (2009)
  • Author(s): Abe K., et al.
  • Journal Title: Neuroscience 159(1) Pages: 316-324
  • Peer Reviewed
• [Journal Article] Comparison of the action potential blocking effects of the local anesthetics in adult rat dorsal root ganglion neurons. (2009)
  • Author(s): Uta D., et al.
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord. 30(1) Pages: 49-57
  • Peer Reviewed
• [Journal Article] The behavioral and electrophysiological analysis of spinal nociceptive transmission in a murine model of bone cancer pain. (2009)
  • Author(s): Yanagisawa Y., et al.
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord. 30(1) Pages: 58-62
  • Peer Reviewed
• [Journal Article] Spinal modulation of nociceptive synaptic transmission via activation of TRPA1 and TRPV1. (2008)
  • Author(s): Uta D, Furue H, Yoshimura M.
  • Journal Title: Pain Research 23(3) Pages: 141-150
  • NAID: 10021942953
  • Peer Reviewed
• [Journal Article] ノイロトロピンによるセロトニン下行性疼痛抑制系の賦活化と鎮痛作用 (2008)
  • Author(s): 岡井恒、古江秀昌、吉村恵
  • Journal Title: Pain Research 23(1) Pages: 11-18
  • NAID: 10024130694
  • Peer Reviewed
• [Journal Article] (contributed equally), N-Ethylmaleimide -sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation. (2008)
  • Author(s): Katano T, Furue H, Okuda-Ashitaka E, Tagaya M, Watanabe M, Yoshimura M, Ito S
  • Journal Title: European Journal of Neuroscience 27(12) Pages: 3161-3170
  • Peer Reviewed
• [Journal Article] N-Ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation (2008)
  • Author(s): Fume H., et al.
  • Journal Title: European Journal of Neuroscience 27(12) Pages: 3161-3170
  • Peer Reviewed
• [Journal Article] Spinal modulation of nociceptive synaptic transmission via activation of TRPA1 and TRPV1. (2008)
  • Author(s): Uta D., et al.
  • Journal Title: Pain Research 23(3) Pages: 141-150
  • Peer Reviewed
• [Presentation] Stimulation of the locus coeruleus modulates synaptic transmission in the rat superficial forsal horn in vivo. (2011)
  • Author(s): 古江秀昌
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: Journal of Physiological Sciences誌上
• [Presentation] Stimulation of the locus coeruleus modulates synaptic transmission in the rat superficial dorsal horn in vivo. (2011)
  • Author(s): Furue H
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: Journal of Physiological Sciences
• [Presentation] In vivo patch-clamp recording analysis of synaptic in the spinal dorsal horn evoked by cutaneous application of a puritogen serotonin (2011)
  • Author(s): Uta D
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: Journal of Physiological Sciences
• [Presentation] In vivo patch-clamp analysis of synaptic responses evoked in the rat locus coeruleus neurons. (2010)
  • Author(s): Sugiyama D
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-24
• [Presentation] Changes in nociceptive behaviors and spinal excitatory synaptic transmission in an murine model of cancer-induced bone pain. (2010)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Imoto K, Yoshimura M.
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-07-02
• [Presentation] ラット脳幹青斑核からのin vivoパッチクランプ記録法の開発 (2010)
  • Author(s): 杉山大介、井本敬二、川真田樹人、古江秀昌
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-07-02
• [Presentation] ラット後根神経節細胞Naチャネルに対する各局所麻酔薬の効果について (2010)
  • Author(s): 歌大介、井本敬二、古江秀昌
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-07-02
• [Presentation] ラット脳幹亜青斑核からのin VIVOパッチクランプ記録法の開発 (2010)
  • Author(s): 杉山大介
  • Organizer: 第32回日本痺痛学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-07-02
• [Presentation] がん性疼痛モデルにおける疼痛関連講堂の変化と脊髄興奮性入力の可塑的変化 (2010)
  • Author(s): 柳澤義和
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-07-02
• [Presentation] ラット後根神経説細胞Naチャネルに対する各局所麻酔薬の効果について (2010)
  • Author(s): 歌大介
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-07-02
• [Presentation] In vivo patch-clamp analysis of surround inhibition of nociceptive transmission in the superficial spinal dorsal horn. (2010)
  • Author(s): 古江秀昌
  • Organizer: 1st Korean Pain Research Consortium (KRPC) Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-06-11
• [Presentation] In vivo patch-clamp analysis of surround inhibition of nociceptive transmission in the superficial spinal dorsal horn. (2010)
  • Author(s): Furue H
  • Organizer: 1st Korean Pain Research Consortium(KRPC)Symposium
  • Place of Presentation: Seoul Korea
  • Year and Date: 2010-06-11
• [Presentation] In vivo 痛覚シナプス伝達の解析 (2010)
  • Author(s): 古江秀昌
  • Organizer: 第5回名古屋大学環境医学研究所・生理学研究所合同シンポジウム
  • Place of Presentation: 生理学研究所明大寺1階会議室(愛知県)
  • Year and Date: 2010-01-29
• [Presentation] Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons. (2010)
  • Author(s): Kohno T, Gerorgiev SK, Furue H
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] The plastic changes of spinal excitatory synaptic transmission in a murine model of cancer-induced bone pain. (2010)
  • Author(s): Yanagisawa Y, Furue H, Kawamata T, Uta D, Imoto K, Iwamoto Y, Yoshimura M.
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] In vivo patch-clamp analysis of synaptic responses evoked in the rat locus coeruleus neurons. (2010)
  • Author(s): Sugiyama D, Imoto K, Kawamata M, Furue H
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
• [Presentation] Bone cancer induces plastic changes in nociceptive excitatory synaptic transmission in the mouse spinal cord. (2010)
  • Author(s): Yanagisawa Y
  • Organizer: 第25階日本整形外科学会基礎学術集会
  • Place of Presentation: 京都国際開館(京都府)
• [Presentation] Touch and pain receptive network formation with RNA binding protein Musashi2 and Pleiotrophin. (2010)
  • Author(s): Shibata S
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
• [Presentation] Firing pattern of substantia gelatinosa neurons receiving TRPA1-expressing afferents in adult rat spinal dorsal horn. (2010)
  • Author(s): Uta D
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
• [Presentation] Inflammation triggers noxious synaptic alteraion in the rat spinal dorsal horn in vivo. (2009)
  • Author(s): Furue H, Imoto K, Yoshimura M.
  • Organizer: The 32nd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Selective loss of presynaptic 5-HT inhibitory actions on spinal mechanical noxious synaptic transmission in ovariectomized rats in vivo. (2009)
  • Author(s): Furue H, Ito A, Yoshimura M.
  • Organizer: XXXVI International Congress of Physiological Sicences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
• [Presentation] 細胞接着因子と痛みのシナプス伝達 (2009)
  • Author(s): 古江秀昌
  • Organizer: 日本ペインクリニック学会第43回大会・第31回日本疼痛学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Electrophysiological and morphological analysis of the actions of TRPA1 and TRPV1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinalcord (2009)
  • Author(s): Uta D
  • Organizer: The 39^<th> Annual Meeting of the Society Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Enhancement of excitatory synaptic transmission in the substantia gelatinosa of the spinal cord in a mouse model of bone cancer pain (2009)
  • Author(s): Yanagisawa Y
  • Organizer: The 39^<th> Annual Meeting of the Society Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Actions of TRPA1 and TRPV1 agonists on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2009)
  • Author(s): Uta D
  • Organizer: The 39^<th> Annual Meeting of the Society Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Actions of endothelin-1 on nociceptive transmission in substantia gelatinosa of the adult mouse spinal cord (2009)
  • Author(s): Nishikawa Y
  • Organizer: The 39^<th> Annual Meeting of the Society Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Pertoneum incision, but not skin and muscle incision, increases spontaneous firing rate of spinal dorsal neurons (2009)
  • Author(s): Sugiyama D
  • Organizer: The 39^<th> Annual Meeting of the Society Neuroscience
  • Place of Presentation: Chicago, USA
• [Presentation] Inflammation triggers noxious synaptic alteration in the rat spinal dorsal horn in vivo (2009)
  • Author(s): 古江秀昌
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Sensory network formation of RNA binding protein Musashi2 (2009)
  • Author(s): Shibata S
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Effects of TRPA1 and TRPV1 agonists on synaptic transmission in morphologically distinct cell types in substantia gelatinosa of the rat spinal cord (2009)
  • Author(s): Uta D
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Contribution of peritoneum incision to generation of spontaneous activity in rat spinaldorsal horn neurons (2009)
  • Author(s): Sugiyama D
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Changes in nociceptive behaviors and spinal excitatory synaptic transmission in a murine model of cancer-induced bone pain (2009)
  • Author(s): Yanagisawa Y
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場(愛知県)
• [Presentation] Selective loss of presynaptic 5-HT inhibitory actions on spinal mechanical noxiuous synaptic transmission in ovariectomized rats in vivo (2009)
  • Author(s): 古江秀昌
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS 2009)
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] Effects of acupuncture on the inhibitory transmission in the spinal doreal horn in vivo (2009)
  • Author(s): Yoshimura M
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS 2009)
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] Changes in properties of spinal dorsal horn neurons after incisional injury in the peritoneum (2009)
  • Author(s): Sugiyama D
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS 2009)
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] Modulation of nociceptive synaptic transmission in the adult rat spinal dorsal horn viaactivation of TRPA1 and TRPV1 (2009)
  • Author(s): Uta D
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS 2009)
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] Plastic changes in spinal nociceptive transmission of born cancer pain model mice (2009)
  • Author(s): Yanagisawa Y
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS 2009)
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] Sensory neural network formation with RNA binding protein Musashi2 deficient mice (2009)
  • Author(s): Shibata S
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS 2009)
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] 痒み情報を伝達する一次求心線維の電気生理学的特徴. (2008)
  • Author(s): 蜂須賀 淳一., et al.
  • Organizer: 第11回皮膚・免疫アレルギー懇話会
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-11-29
• [Presentation] Electrophysiological property of itch sensing primary afferents. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: 18th International Symposium of Itch
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-10-25
• [Presentation] 炎症時における脊髄痛覚伝達とグルタミン酸受容体の発現変化. (2008)
  • Author(s): 古江 秀昌.
  • Organizer: 第1回九大痛みの研究会
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2008-10-06
• [Presentation] 脊髄後角におけるモダリティ依存的なシナプス入力とその抑制回路. (2008)
  • Author(s): 古江秀昌.
  • Organizer: 生理学研究所部門公開セミナー
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2008-09-25
• [Presentation] In vivo patch-clamp analysis of plastic changes in spinal sensory transmission. (2008)
  • Author(s): Fume H.
  • Organizer: Seminars in Physiology and Pharmacology at University of Bristol
  • Place of Presentation: Bristol, UK
  • Year and Date: 2008-08-14
• [Presentation] 感覚モダリティのシナプス伝達と細胞接着因子. (2008)
  • Author(s): 古江秀昌.
  • Organizer: ひびきの神経科学セミナー
  • Place of Presentation: 福岡県北九州市
  • Year and Date: 2008-07-03
• [Presentation] 生理学の立場から 光学異性体の末梢神経(DRG)への作用の違い (2008)
  • Author(s): 古江秀昌
  • Organizer: 日本臨床麻酔学会第28回大会学術集会・総会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] In vivo patch-clamp analysis of nociceptive synaptic transmission through calcium-permeable AMPA receptors in substantia gelatinosa neurons of the rat spinal dorsal horn following inflammation. (2008)
  • Author(s): Furue H, Yoshimura M
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washignton DC, USA
• [Presentation] Stimulation of the locus coeruleus increases excitatory transmission onto dorsal horn neurons of the rat in vivo. (2008)
  • Author(s): Furue H, Yoshimura M, Pickering AE.
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow, UK
• [Presentation] Plastic change in the spinal nociceptive transmission mediated by Ca2+-permeable AMPA receptors in vivo after inflammation. (2008)
  • Author(s): Furue H, Yoshimura M.
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] Functional loss of menthol-sensitive synaptic inputs to spinal dorsal horn neurons in cadherin-8 deficient mice. (2008)
  • Author(s): Furue H, Suzuki S, Koga K, Nohmi M, Takeichi M, Yoshimura M.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Enhancement of excitatory and inhibitory synaptic transmission in the rat spinal dorsal horn by stimulation of the locus coeruleus in vivo. (2008)
  • Author(s): Furue H, Yoshimura M, Pickering AE.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] In vivo パッチクランプ法を用いた脊髄痛覚伝達におけるCa^<2+>透過性AMPA受容体の機能解析. (2008)
  • Author(s): 古江 秀昌., et al.
  • Organizer: 第10回ブレインサイエンス研究会
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Actions of noradrenaline and midazolam on inhibitory aynaptic responses evoked in substantia gelatinosa neurons of the rat spinal cord. (2008)
  • Author(s): Maeda A., et al.
  • Organizer: The 55th Annual Meeting ofJapanese Society of Anesthesiologists
  • Place of Presentation: Yokohama, Japan
• [Presentation] Enhancement of excitatory and inhibitory synaptic transmission in the ratspinal dorsal horn by stimulation of the locus coeruleus in vitro. (2008)
  • Author(s): Furue H., et al.
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Tokyo, Japan
• [Presentation] Plastic changes in descending serotonergic inhibition of spinal noxious mechanical synaptic transmission following ovariectomy. (2008)
  • Author(s): Furue H., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] In vivo patch-clamp analysis of descending spinal modulation from locus coeruleus in rats. (2008)
  • Author(s): Furue H., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] The behavioral and electrophysiological analysis of spinal nociceptive transmission in a murine model of bone cancer pain. (2008)
  • Author(s): Yanagisawa Y., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Electrophysiological and morphological analyzes of excitatory effect of TRPA1 agonists on synaptic transmission in excitatory intemeurons in the adult rat spinal dorsal horn neurons. (2008)
  • Author(s): Uta D., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Electrophysiological property of itch sensing primary afferents. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Plastic change in the spinal nociceptive transmission mediated by Ca^<2+>-permeable AMPA receptors in vivo after inflammation. (2008)
  • Author(s): Fume H., et al.
  • Organizer: The 30th Annual Meeting of Japanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Comparison of blocking effect of the local anesthetics on primary afferent synaptic transmission of the adult rat spinal dorsal horn neurons. (2008)
  • Author(s): Uta D., et al.
  • Organizer: The 30th Annual Meeting of Japanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Mechanisms of itch sensation in DRG neurons revealed by in vivo intracellular recordings. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: The 30th Annual Meeting of Japanese Association for the Study of Pain
  • Place of Presentation: Fukuoka, Japan
• [Presentation] セロトニンを介した脊髄痛覚シナプス伝達抑制の可塑的変化-In vivo パッチクランプ法を用いた解析-. (2008)
  • Author(s): 古江 秀昌., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] In vivo パッチクランプ法を用いたラットー次体性感覚野における痛覚応答の解析. (2008)
  • Author(s): 古賀 浩平., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] CaMK IVノックアウトマウスを用いた行動薬理的および電気生理学的検討 (2008)
  • Author(s): 歌 大介., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] ガン性疼痛モデルにおける痛覚伝達系異常の行動学的および電気生理学的解析. (2008)
  • Author(s): 柳澤 義和., et al.
  • Organizer: 第59回西日本生理学会
  • Place of Presentation: Kumamoto, Japan
• [Presentation] Inputs of the noxious heat sensation to the spinal dorsal horn revealed by in vivo patch-clamp recordins. (2008)
  • Author(s): Yoshimura M., et al.
  • Organizer: Current Trends in Biomedicine Workshop : Understanding Pain : From Transduction to Sensation
  • Place of Presentation: Baeza, Spain
• [Presentation] 癌性疼痛モデルにおける痛覚伝達系異常の電気生理学的解析. (2008)
  • Author(s): Yanagisawa Y., et al.
  • Organizer: The 23rd Annual Research Meeting of the Japanese Orthopaedic Association
  • Place of Presentation: Kyoto, Japan
• [Presentation] In vivo patch-clamp analysis of nociceptive synaptic transmission through calcium-permeable AMPA receptors in substantia gelatinosa neurons of the rat spinal dorsal horn following inflammation. (2008)
  • Author(s): Fume H., et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Roles of Clacium / Calmodulin-dependent protein kinase IV on nociceptive transmission in substantia gelatinosa of the adult mouse spinal cord. (2008)
  • Author(s): Uta D., et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Electrophysiological analysis of itch sensing primary afferents. (2008)
  • Author(s): Hachisuka J., et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] Behavioral and electrophysiological analyses of spinal nociceptive transmission in a murine model of cancer-induced bone pain. (2008)
  • Author(s): Yanagisawa Y., et al.
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
• [Presentation] 生理学の立場から 光学異性体の末梢神経(DRG)への作用の違い. (2008)
  • Author(s): 古江 秀昌.
  • Organizer: 日本臨床麻酔学会第28回大会学術集会総会
  • Place of Presentation: Kyoto, Japan
• [Presentation] In vivoパッチクランプ法を用いた痛覚伝達回路の解析. (2008)
  • Author(s): 古江秀昌.
  • Organizer: 平成20年度生理学研究所研究会「大脳皮質機能単位の神経機構」
  • Place of Presentation: 愛知県岡崎市
• [Book] Modern Patch Clamp Techniques(In vivo blind patch-clamp recording technique) (2011)
  • Author(s): 古江秀昌
  • Publisher: Springer-Verlag(in press)
• [Book] 最新パッチクランプ実験技術法(In vivoブラインドパッチ法) (2011)
  • Author(s): 古江秀昌
  • Publisher: 吉岡書店
• [Book] Modern Patch Clamp Techniques (2011)
  • Author(s): Furue H
  • Publisher: Springer(In press)
• [Book] 最新パッチクランプ実験技術法 (2011)
  • Author(s): 古江秀昌
  • Publisher: 吉岡書店
• [Book] レボブピバカインの基礎と臨床(生理学の立場から光学異性体の末梢神経(後根神経節細胞)への作用の違い) (2010)
  • Author(s): 古江秀昌,杉山大介
  • Publisher: 克誠堂出版
• [Book] レボブピバカインの基礎と臨床 (2010)
  • Author(s): 古江秀昌
  • Publisher: 克誠堂出版
• [Book] レボブビバカインの基礎と臨床 (2010)
  • Author(s): 古江秀昌, et al.
  • Publisher: 克誠堂出版(印刷中)
• [Remarks] ホームページ等
• [Remarks]
  • URL: http://www.nips.ac.jp/huinfo/research/index.htm