In vivo patch-clamp analysis of plastic changes in descending inhibitory system
| Project/Area Number |
20602003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kyushu University |
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Principal Investigator |
FURUE Hidemasa Kyushu University, 生体情報研究系, 准教授 (20304884)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Megumu 九州大学, 医学研究院, 教授 (10140641)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA Megumu 熊本保健科学大学, 保健科学部, 教授 (10140641)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シナプス / 感覚 / ノルアドレナリン / 鎮痛 / 青斑核 / 下行性痛覚抑制 / in vivoパッチクランプ / 神経回路 / ニューロン / 痛覚 / EPSC / IPSC / 膠様質 |
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| Research Abstract |
Descending noxious inhibitory system was studied by using in vivo patch-clamp recording technique. The present main finding is that stimulating the locus coeruleus enhances spinal inhibitory synaptic transmission.
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Report
(4 results)
Research Products
(108 results)
