| Project/Area Number |
20602009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Aichi Medical University |
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Principal Investigator |
IWASE Satoshi (2010) Aichi Medical University, 医学部, 教授 (90184879)
熊澤 孝朗 (熊沢 孝朗) (2008-2009) Aichi Medical University, 客員教授 (20022775)
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| Co-Investigator(Kenkyū-buntansha) |
OHISHI Hitoshi 愛知医科大学, 医学部, 准教授 (00252461)
岩瀬 敏 愛知医科大学, 医学部, 教授 (90184879)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKURAI Hiroki 浜松大学, 保健医療学部, 講師 (60454419)
EGUCHI Kunihiro 愛知学院大学, 歯学部, 非常勤講師 (30113062)
USHIDA Takahiro 愛知医科大学, 医学部, 教授 (60304680)
KOZAKI Yasuko 金城学院大学, 薬学部, 准教授 (20126882)
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| Research Collaborator |
YOSHIMOTO Takahiko 愛知医科大学
YAMAGUCHI Yoshiko 愛知医科大学
MORIMOTO Atsuko 愛知医科大学
OHMICHI Yusuke 愛知医科大学
OHMICHI Mika 愛知医科大学
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 痛み / 慢性痛 / 動物モデル / 筋障害 / 免疫・炎症 / 自律神経 / グリア / 分子生物学 / 免疫組織 |
|---|
| Research Abstract |
In the chronic pain animal model caused by muscle insult with immuno-inflammatory and nociceptive stimuli, it was clarified that the delicate interaction between the immuno-inflammatory background and the nociceptive neural inputs may be essential to form long-persisting hypersensitivity, because pretreatment with larger-dose of immuno-inflammatory agent or treatment to immature animal prevented the development of long lasting hypersensitivity. In the cast immobilization model, it was observed that activation of spinal glial cells spread in response to spreading hypersensitivity. The sympathetic activity in this model was augmented during unilateral immobilizing, and then decreased below normal level while persisting pain behavior continued.
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