Analysis of mechanism of lumber pain that focused in pain sensor such as TRP channels.
| Project/Area Number |
20602019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
YOKOYAMA Toru University of Occupational and Environmental Health, Japan, 医学部, 助教 (80425321)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Kouichiro 自治医科大学, 医学部, 講師 (70279347)
UETA Yoichi 産業医科大学, 医学部, 教授 (10232745)
岡本 隆史 産業医科大学, 医学部, 非常勤助教 (60446119)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 疼痛 / TRP / チャネル / 鎮痛 / 脳神経 / 電気生理学 / カルシウム |
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| Research Abstract |
We demonstrated pain sensor TRPV1 is essential for osmo-regulation in central nerves systems. TRPA1 agonists potentiate excitatory synaptic inputs to the SON. We found the possibility that vasopressin strongly participated in a pain.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Exaggerated response of a vasopressin -enhansed green fluorescent protein transgene to nociceptive stimulation in the rat.2009
Author(s)
Suzuki H, Kawasaki M, Ohnishi H, Ohbuchi T, Katoh A, Hashimoto H, Yokoyama T, Fujihara H, Dayanithi G, Murphy D, Nakamura T, Ueta Y.
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Journal Title
Journal of Neuroscience 29(42)
Pages: 13182-13189
Related Report
Peer Reviewed
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