Synthesis and properties of 4'-selenoRNA based on biological equivalence
| Project/Area Number |
20611001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAKAWA Noriaki Hokkaido University, 大学院・ヘルスバイオサイエンス研究部, 教授 (40209820)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ヌクレオシド / RNA / 4'-セレノRNA / 生物学的等価性 / セレン |
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| Research Abstract |
In this work, I aimed to prepare a new chemically modified RNA molecule exhibiting a biological equivalence with natural RNA. To be concrete, 4'-selenoRNA and 2'-OMe-4'-selenoRNA, in which the furanose ring oxygen is replaced by a seleno atom, were prepared and their properties were examined. Accordingly, these RNA molecules showed a higher hybridization property and nuclease resistance.
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Report
(4 results)
Research Products
(41 results)
