脂肪酸結合蛋白質によるドパミン受容体調節と神経機能における役割

• Project/Area Number: 20659008
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: 福永 浩司 Tohoku University, 大学院・薬学研究科, 教授 (90136721)
• Co-Investigator(Kenkyū-buntansha): 笠原 二郎 東北大学, 大学院・薬学研究科, 講師 (10295131) ; 塩田 倫史 東北大学, 大学院・薬学研究科, 助手 (00374950)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,300,000 (Direct Cost: ¥3,300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000); Fiscal Year 2008: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 心臓型脂肪酸結合蛋白質 / ドパミンD2受容体 / 線条体 / カタレプシー / アセチルコリン / ノックアウトマウス / 認知機能 / 多価不飽和脂肪酸 / 帯状回皮質 / 脳由来神経栄養因子 / CaMキナーゼII / CREB / 恐怖行動

Research Abstract

私達はこれまでに心臓型脂肪酸結合蛋白質(H-FABP)の欠損マウスにおいて常同行動と認知機能の異常、恐怖行動の亢進が起こることを見出した。脳内ドパミン神経はこれらの行動発現に関与すること、H-FABPはドパミンD2受容体との結合することから、H-FABP欠損マウスのドーパミン神経機能について解析した。最初にH-FABP欠損マウスにメタンフェタミンを投与し、ドパミンD2受容体の機能異常について調べた。また、ドパミンD2受容体拮抗薬であるハロペリドールによるカタレプシー現象を検討した。さらに、背側線条体におけるマイクロダイアリシス法を用いて、ハロペリドール刺激によるアセチルコリン(ACh)の放出を検討した。結果として、H-FABP欠損マウスではメタンフェタミンに対する感受性が有意に減弱した。さらに、H-FABP欠損マウスにおいてドパミンD2受容体拮抗薬の投与によるカタレプシー現象の有意な亢進が見られ、H-FABP欠損マウスではカタレプシーが亢進する同じ用量で、線条体でのハロペリドール誘発のACh遊離が顕著に亢進していた。免疫染色法によりH-FABPが背側線条体のACh神経細胞に強く発現することを確認した。さらに、培養神経様細胞を用いてH-FABPがドパミンD2受容体の機能を亢進させることを初めて証明した。これらの結果は、H-FABP欠損マウスに見られたカタレプシー現象の亢進には線条体におけるACh神経におけるD2受容体の機能異常が関わることを示唆している。

Research Products

• [Journal Article] ranscriptional upregulation of calcineurin Abeta by endothelin-1 is partially mediated by calcium/calmodulin-dependent protein kinase IIdelta3 in rat cardiomyocytes. (2010)
  • Author(s): YM.Lu, N.Shioda, Y.Yamamoto, F.Han, K.Fukunaga
  • Journal Title: Biochim.Biophys.Acta. (印刷中)
  • Peer Reviewed
• [Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice. (2010)
  • Author(s): K.Takao, K.Tanda, K.Nakamura, J.Kasahara, K.Nakao, M.Katsuki, K.Nakanishi, N.Yamasaki, K.Toyama, M.Adachi, M.Umeda, T.Araki, K.Fukunaga, H.Kondo, H.Sakagami, T.Miyakawa.
  • Journal Title: PLoS One 5
  • Peer Reviewed
• [Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons. (2010)
  • Author(s): M.Sanda, N.Ohara, A.Kamata, Y.Hara, H.Tamaki, J.Sukegawa, T.Yanagisawa, K.Fukunaga, H.Kondo, H.Sakagami
  • Journal Title: Neurosci.Res. (印刷中)
  • Peer Reviewed
• [Journal Article] Heart-type fatty acid binding protein regulates dopamine D2 receptor function in mouse brain. (2010)
  • Author(s): N.Shioda, Y.Yamamoto, M.Watanabe, B.Binas, Y.Owada, K.Fukunaga
  • Journal Title: J.Neurosci. 30 Pages: 3146-3155
  • Peer Reviewed
• [Journal Article] The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells. (2010)
  • Author(s): QB.Liu, LL.Liu, YM.Lu, RR.Tao, JY.Huang, N.Shioda, S.Moriguchi, K.Fukunaga.F.Han, YJ.Lou
  • Journal Title: Toxicol.Appl.Pharmacol. (印刷中)
  • Peer Reviewed
• [Journal Article] Quantitative measurement of In Vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE. (2010)
  • Author(s): T.Hosokawa, T.Saito, A.Asada, K.Fukunaga, SI.Hisanaga
  • Journal Title: Mol.Cell Proteomics. (印刷中)
  • Peer Reviewed
• [Journal Article] A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olf actory Bulbectomized Mice. (2010)
  • Author(s): N.Shioda, Y.Yamamoto, F.Han, S.Moriguchi, Y.Yamaguchi, M.Hino, K.Fukunaga
  • Journal Title: J.Pharmacol.Exp.Ther. 333 Pages: 43-50
  • Peer Reviewed
• [Journal Article] Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice. (2010)
  • Author(s): F.Han, YM.Lu, H.Hasegawa, H.Kanai, E.Hachimura, Y.Shirasaki, K.Fukunaga
  • Journal Title: J.Pharmacol.Exp.Ther. 332 Pages: 421-428
  • Peer Reviewed
• [Journal Article] Characterization of an animal model of postmenopausal cardiac hypertrophy and novel mechanisms responsible for cardiac decompensation using ovariectomized pressure-overloaded rats. (2010)
  • Author(s): MS.Bhuiyan, K.Fukunaga
  • Journal Title: Menopause 17 Pages: 213-221
  • Peer Reviewed
• [Journal Article] Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats. (2009)
  • Author(s): MS.Bhuiyan, N.Shioda, M.Shibuya, Y.Iwabuchi, K.Fukunaga
  • Journal Title: Hypertension 53 Pages: 57-63
  • Peer Reviewed
• [Journal Article] The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53, through its proline-rich sequence. (2009)
  • Author(s): M.Sanda, A.Kamata, O.Katsumata, K.Fukunaga, M.Watanabe, H.Kondo, H.Sakagami
  • Journal Title: Brain Res. 1251 Pages: 7-15
  • Peer Reviewed
• [Journal Article] DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities. (2009)
  • Author(s): YM.Lu, N.Shioda, F.Han, A.Kamata, Y.Shirasaki, ZH.Qin, K.Fukunaga
  • Journal Title: Cardiovasc.Ther. 27 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice. (2009)
  • Author(s): F.Han, T.Nakano, Y.Yamamoto, N.Shioda, YM.Lu, K.Fukunaga
  • Journal Title: Brain Res. 1265 Pages: 205-214
  • Peer Reviewed
• [Journal Article] Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats. (2009)
  • Author(s): MS.Bhuiyan, N.Shioda, K.Fukunaga
  • Journal Title: Expert Opin.Ther.Targets 13 Pages: 275-286
  • Peer Reviewed
• [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation. (2009)
  • Author(s): S.Moriguchi, N.Shioda, F.Han, JZ.Yeh, T.Narahashi, K.Fukunaga
  • Journal Title: Hippocampus 19 Pages: 844-854
  • Peer Reviewed
• [Journal Article] p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. (2009)
  • Author(s): XD.Zhang, Y.Wang, Y.Wang, X.Zhang, R.Han, JC.Wu, ZQ.Liang, ZL.Gu, F.Han, K.Fukunaga, ZH.Qin
  • Journal Title: Autophagy 5 Pages: 339-350
  • Peer Reviewed
• [Journal Article] Prandial increases of leptin and orexin in the brain modulate spatial learning and memory. (2009)
  • Author(s): Y.Oomura, S.Aou, K.Fukunaga, S.Moriguchi, K.Sasaki
  • Journal Title: Ross.Fiziol.Zh.Im.I.M.Sechenova 95 Pages: 1373-1385
  • Peer Reviewed
• [Journal Article] Prandial increase of leptin in the brain activates spatial learning and memory. (2009)
  • Author(s): Y.Oomura, S.Aou, K.Fukunaga
  • Journal Title: Pathophysiology 17 Pages: 119-127
  • Peer Reviewed
• [Journal Article] Generation and Characterization of Conditional Heparin-Binding EGF-Like Growth Factor Knockout Mice. (2009)
  • Author(s): A.Oyagi, Y.Oida, K.Kakefuda, M.Shimazawa, N.Shioda, S.Moriguchi, K.Kitaichi, D.Nanba, K Yamaguchi, Y.Furuta, K.Fukunaga, S.Higashiyama, H.Hara.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist. (2009)
  • Author(s): M.Lu, F.Han, N.Shioda, S.Moriguchi., Y.Shirasaki, ZH.Qin, K.Fukunaga
  • Journal Title: Mol.Pharmacol. 75 Pages: 101-112
  • Peer Reviewed
• [Journal Article] Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target. (2009)
  • Author(s): MS.Bhuiyan, K.Fukunaga
  • Journal Title: Curr.Drug Targets 10 Pages: 372-383
  • Peer Reviewed
• [Journal Article] lomoucine inhibits cathepsin L nuclear translocation, activates autophagy and attenuates toxicity of 6-hydroxydopamine. (2009)
  • Author(s): XF.Fei, ZH.Qin, B.Xiang, LY.Li, F.Han, K.Fukunaga, ZQ.Liang
  • Journal Title: Brain Res. 1264 Pages: 85-97
  • Peer Reviewed
• [Journal Article] Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. (2009)
  • Author(s): S.Moriguchi, X.Zhao, W.Marszalec, JZ.Yeh, K.Fukunaga, T.Narahashi
  • Journal Title: Neuroscience 160 Pages: 484-491
  • Peer Reviewed
• [Journal Article] Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. (2009)
  • Author(s): S.Moriguchi, F.Han, N.Shioda, Y.Yamamoto, T.Nakajima, O.Nakagawasai, T.Tadano, JZ.Yeh, T.Narahashi, K.Fukunaga
  • Journal Title: J.Neurochem. 110 Pages: 170-181
  • Peer Reviewed
• [Journal Article] Role of Akt and ERK signaling in the neurogenesis following brain ischemia. (2009)
  • Author(s): N.Shioda, F.Han, K.Fukunaga
  • Journal Title: Int.Rev.Neurobiol. 85 Pages: 375-387
  • Peer Reviewed
• [Journal Article] Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation. (2009)
  • Author(s): Y.Yamamoto, N.Shioda, F.Han, S.Moriguchi, A.Yokosuka, Y.Mimaki, Y.Sashida, T.Yamakuni, Y.Ohizumi, K.Fukunaga
  • Journal Title: Brain Res. 1295 Pages: 218-229
  • Peer Reviewed
• [Journal Article] Ca2+/Calmodulin-dependent Protein Kinase IV-mediated LIM-kinase Activation Is Critical for Calcium Signal-induced Neurite Outgrowth. (2009)
  • Author(s): M.Takemura, T.Mishima, Y.Wang, J.Kasahara, K.Fukunaga, K.Ohashi, K Mizuno
  • Journal Title: J.Biol.Chem. 284 Pages: 28554-28562
  • Peer Reviewed
• [Journal Article] Stimulation of Sigma-1 receptor signaling by dehydroepiandrosterone ameliorates pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats. (2009)
  • Author(s): MS.Bhuiyan, K.Fukunaga
  • Journal Title: Expert Opin.Ther.Targets 13 Pages: 1253-1265
  • Peer Reviewed
• [Journal Article] Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum. (2009)
  • Author(s): XD.Zhang, Y.Wang, JC.Wu, X.F.Lin, R.Han, F.Han, K.Fukunaga, ZH.Qin.
  • Journal Title: J.Neurosci.Res. 87 Pages: 3600-3610
  • Peer Reviewed
• [Journal Article] Pathophysiological Relevance of Forkhead Transcription Factors in Brain Ischemia (2009)
  • Author(s): K.Fukunaga, N.Shioda
  • Journal Title: Forkhead Transcription Factor : Vital Elements in Biology and Medicine(ed. K. Maiese)(Landes Bioscience) Pages: 130-142
• [Journal Article] The Function of CaM Kinase II in Synaptic Plasticity and Spine Formation (2009)
  • Author(s): K.Fukunaga, N.Shioda, E.Miyamoto
  • Journal Title: Handobook of Neurochemistry and Molecular Neurobiology. Neural Signaling Mechanisms(ed. A. Lajtha. Vol.ed. K. Mikoshiba)(Springer) Pages: 163-184
• [Journal Article] Nefiracetam and Galantamine Modulation of Excitatory and Inhibitory Synaptic Transmission via Stimulation of Neuronal Nicotinic Acetylcholine Receptors in Rat Cortical Neurons (2009)
  • Author(s): Moriguchi S, Zhao X, Marszalec W, Yeh JZ, Fukunaga K, Narahashi T.
  • Journal Title: Neuroscience (in press)
  • Peer Reviewed
• [Journal Article] Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation (2009)
  • Author(s): Moriguchi S, Shioda N, Han F, Yeh JZ, Narahashi T, Fukunaga K.
  • Journal Title: Hippocampus (in press)
  • Peer Reviewed
• [Journal Article] Chronic beta-AR activation-induced calpain activation and impaired eNOS-Akt signaling mediates cardiac injury in ovariectomized female rats (2009)
  • Author(s): Bhuiyan MS, Shioda N, Fukunaga K.
  • Journal Title: Expert Opin Ther Targets 13 Pages: 275-286
  • Peer Reviewed
• [Journal Article] Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized mice (2009)
  • Author(s): Han F, Nakano T, Yamamoto Y, Shioda N, Lu YM, Fukunaga K.
  • Journal Title: Brain Res (in press)
  • Peer Reviewed
• [Journal Article] DY-9760e Inhibits Endothelin-1-induced Cardiomyocyte Hypertrophy Through Inhibition of CaMKII and ERK Activities (2009)
  • Author(s): Lu YM, Shioda N, Han F, Kamata A, Shirasaki Y, Qin ZH. Fukunaga K.
  • Journal Title: Cardiovasc Ther 27 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Role of heart-type fatty acid binding protein in the brain function (2009)
  • Author(s): Motohashi K, Yamamoto Y, Shioda N, Kondo H, Owada Y, Fukunaga K.
  • Journal Title: Yakugaku Zasshi 129 Pages: 191-195
  • NAID: 110007046096
• [Journal Article] The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence (2009)
  • Author(s): Sanda M, Kamata A, Katsumata O, Fukunaga K, Watanabe M, Kondo H, Sakagami H.
  • Journal Title: Brain Res 1251 Pages: 7-15
  • Peer Reviewed
• [Journal Article] Activation of endothelial nitric oxide synthase by a vanadium compound ameliorates pressure overload-induced cardiac injury in ovariectomized rats (2009)
  • Author(s): Bhuiyan MS, Shioda N, Shibuya M, Iwabuchi Y, Fukunaga K.
  • Journal Title: Hypertension 53 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Phenylephrine-induced cardiomyocyte injury is triggered by super oxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 342[4-(3-chloro-2-methylphenyl)-1-pipera zinyllethy1]-5, 6-dintethoxyindazole (DY-9836), a novel calmodulin antagonist (2009)
  • Author(s): Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K.
  • Journal Title: Mol Pharmacol 75 Pages: 101-112
  • Peer Reviewed
• [Journal Article] Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders (2008)
  • Author(s): Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J., Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Mivakawa T.
  • Journal Title: Mol Brain 1 Pages: 6-6
  • Peer Reviewed
• [Journal Article] Activation of HtrA2, a mitochondrial serine protease mediates a poptosis : current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury (2008)
  • Author(s): Bhuiyan MS, Fukunaga K.
  • Journal Title: Cardiovasc Ther 26 Pages: 224-232
• [Journal Article] Targeting protein kinase B/Akt signaling with vanadium compounds for cardioorotection (2008)
  • Author(s): Bhuiyan MS, Shioda N, Fukunaga, K.
  • Journal Title: Expert Opin Ther Targets 12 Pages: 1217-1227
• [Journal Article] Fatty acid-binding protein regulates LPS-induced TNF-alpha production in mast cells (2008)
  • Author(s): Yamamoto N, Kaneko I, Motohashi K, Sakagami H, Machi Y, Tokuda N, Sawada T, Furukawa H, Ueyama Y, Fukunaga K, Ono M, Kondo H, Owada Y.
  • Journal Title: Prostaglandins Leukot Essent Fatty Acids 79 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways (2008)
  • Author(s): Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Fukunaga K, Qin ZH.
  • Journal Title: Autophagy 4 Pages: 762-769
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders (2008)
  • Author(s): Fukunaga K, Shioda N, Morioka M. Han F
  • Journal Title: Nippon Yakurigaku Zasshi 131 Pages: 341-346
  • NAID: 10024382659
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein (2008)
  • Author(s): Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J. Fukunaga K.
  • Journal Title: Cardiovasc Ther 26 Pages: 10-23
  • Peer Reviewed
• [Journal Article] CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region (2008)
  • Author(s): Moriguchi S, Shioda N, Han F, Narahashi T, Fukunaga K.
  • Journal Title: J Neurochem 106 Pages: 1092-1103
  • Peer Reviewed
• [Presentation] 心臓型脂肪酸結合蛋白質は中枢ドパミン神経活動を調節する. (2010)
  • Author(s): 山本由似、塩田倫史、大和田祐二、福永浩司
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 脳虚血におけるバナジウム化合物の神経・血管保護効果 (2010)
  • Author(s): 塩田倫史、福永浩司
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] 新規アルツハイマー治療薬の認知機能改善とうつ症状改善作用の神経機序 (2010)
  • Author(s): 福永浩司、塩田倫史、山本由似、森口茂樹
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
• [Presentation] ヒスタミンH3受容体に結合する細胞内タンパク質の機能解析 (2010)
  • Author(s): 木下和樹、廣田佳那、佐藤岳哉、前田恵、原口満也、福永浩司、柳澤輝行、助川淳
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] ジストロフィン分解とeNOSアンカップリングは心肥大による心筋障害の原因である. (2010)
  • Author(s): 福永浩司、Lu Yingmei、韓峰
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] ドパミンD2受容体に対する脂肪酸結合蛋白質の機能的役割 (2010)
  • Author(s): 塩田論史、山本由似、大和田祐二、福永浩司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] マウス大脳皮質初代培養神経細胞におけるセロトニンによるCREBリン酸化反応はCaMKIVとMAPK (ERK)を介する. (2010)
  • Author(s): 笠原二郎、大村幸司、福永浩司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] CaMキナーゼIIとプロテインキナーゼCの活性化を介したPAFによる海馬シナプス伝達の増強. (2010)
  • Author(s): 森口茂樹、福永浩司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] フルボキサミンはSigma-1受容体を刺激してTACによる心筋障害を抑制する. (2010)
  • Author(s): 田頭秀章、Md.Shenuarin、Bhuiyan、塩田倫史、森口茂樹、福永浩司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] ヒスタミンH3受容体に結合する細胞内蛋白質の機能解析. (2009)
  • Author(s): 木下和樹、高柳詩織、前田恵、原口満也、佐藤岱哉、谷内一彦、福永浩司、柳澤輝行、助川淳
  • Organizer: 第60回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2009-09-26
• [Presentation] 嗅球摘出マウスにおける海馬内アセチルコリン遊離に対するZSET1446の促進作用 (2009)
  • Author(s): 山本由似、韓峰、塩田倫史、森口茂樹、福永浩司
  • Organizer: 第60回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2009-09-26
• [Presentation] バナジウム化合物VO(OPT)末梢投与による脳虚血耐性現象の誘導. (2009)
  • Author(s): 鈴木寿栄、塩田倫史、福永浩司
  • Organizer: 第60回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2009-09-26
• [Presentation] 認知機能改善薬ZSET1446の脳内アセチルコリン遊離作用. (2009)
  • Author(s): 山本由似、韓峰、塩田倫史、森口茂樹、福永浩司
  • Organizer: 第11回応用薬理シンポジウム
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-18
• [Presentation] 脳特異的受容体様タンパク質欠損マウスの不安様行動と扁桃体神経活動異常. (2009)
  • Author(s): 生野達也、森口茂樹、竹島浩、福永浩司
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] 神経新生を促進する新しいアルツハイマー病治療薬ZSET1446(ST101)の神経作用機序. (2009)
  • Author(s): 塩田倫史、韓峰、森口茂樹、山口芳正、日野正孝、福永浩司
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] A novel rat model of postmenopausal myocardial hypertrophy. (2009)
  • Author(s): Shenuarin Bhuiyan、福永浩司
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] ヒスタミンH3受容体に結合するタンパク質の新たな同定とその機能解析. (2009)
  • Author(s): 木下和樹、高柳詩織、佐藤岳哉、前田恵、原口満也、谷内一彦、福永浩司、柳澤輝行、助川淳
  • Organizer: 第6回東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] 脂肪酸結合タンパク質はドパミンD2受容体の機能調節に関与する. (2009)
  • Author(s): 塩田倫史、大和田祐二、山本由似、福永浩司
  • Organizer: 日本生化学会東北支部第75回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-09
• [Presentation] 脂肪酸輸送タンパク質によるドパミンD2受容体の制御機構 (2009)
  • Author(s): 塩田倫史、山本由似、大和田祐二、福永浩司
  • Organizer: 第18回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター情文ホール(口演)
  • Year and Date: 2009-03-19
• [Presentation] Na+/Ca2+交換体(NCX)type2欠損マウスにおける細胞内カルシウム異常と認知機能障害 (2009)
  • Author(s): 森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
  • Organizer: 第18回神経行動薬理若手研究者の集い
  • Place of Presentation: 横浜情報文化センター情文ホール
  • Year and Date: 2009-03-19
• [Presentation] アルツハイマー病治療薬を目指したα4β2アセチルコリン受容体選択的アゴニストの探索 (2009)
  • Author(s): 福永浩司
  • Organizer: 特定研究「ニコチンの神経伝達調節作用に関する研究」第2回検討会
  • Place of Presentation: 虎ノ門パストラル(口演)
  • Year and Date: 2009-01-27
• [Presentation] Na+/Ca2+交換体の認知機能調節における役割. (2009)
  • Author(s): 森口茂樹、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
  • Organizer: 平成21年度生理学研究所研究会シナプス研究会「シナプス機能と病態」
  • Place of Presentation: 愛知
• [Presentation] 精神遅滞モデルマウスにおけるスパイン形成異常とCAMキナーゼII. (2009)
  • Author(s): 塩田倫史、別府秀幸、北島勲、福永浩司
  • Organizer: 平成21年度生理学研究所研究会シナプス研究会「シナプス機能と病態」
  • Place of Presentation: 愛知
• [Presentation] ラット4血管閉塞モデルにおけるバナジウム化合物VO (OPT)末梢投与による虚血耐性誘導 (2009)
  • Author(s): 塩田倫史、福永浩司
  • Organizer: 第21回日本脳循環代謝学会総会
  • Place of Presentation: 大阪
• [Presentation] 脂肪酸結合蛋白質H-FABPによるドパミンD2受容体の機能調節 (2009)
  • Author(s): 塩田倫史、山本由似、大和田祐二、福永浩司
  • Organizer: 第39回日本神経精神薬理学会
  • Place of Presentation: 京都
• [Presentation] 認知機能改善薬ZSET1446は嗅球摘出マウスにおける海馬アセチルコリン遊離を促進する. (2009)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、山口芳正、日野正孝、福永浩司
  • Organizer: 第39回日本神経精神薬理学会
  • Place of Presentation: 京都
• [Presentation] Critical role of interaction between H-FABP and dopamine D2 receptor in emotional behaviors. (2009)
  • Author(s): K.FUKUNAGA, N.SHIODA, Y.YAMAMOTO, Y.OWADA
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
• [Presentation] Heart-type fatty acid binding protein regulates dopamine D2 receptor functions in mouse brain. (2009)
  • Author(s): N.SHIODA, Y.YAMAMOTO, M.WATANABE, Y.OWADA, K.FUKUNAGA
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
• [Presentation] Impairment of cognitive function through downregulation of CaM kinase II activation in Na+/Ca2+. exchanger type-2 knockout mice. (2009)
  • Author(s): S.MORIGUCHI, F.HAN, N.SHIODA, S.KITA, I.KOMURO, T.IWAMOTO, K.FUKUNAGA
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
• [Presentation] Generation of soluble Fas-ligand(sFasL)by a disintegrin and metallopeptidase 10(ADAM10)induced neural death following brain ischemia. (2009)
  • Author(s): Y.YAMAMOTO, N.SHIODA, M.MORIOKA, K.FUKUNAGA
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
• [Presentation] Essential role of diacylglycerol kinase beta(DGKB)in neurite spine formation, cognitive function, and memory. (2009)
  • Author(s): Y.SHIRAI, T.KOZUKI, K.KAKEFUDA, S.MORIGUCHI, A.OYAGI, K.HORIE, M.SHIMAZAWA, K.FUKUNAGA, J.TAKEDA, N.SAITO, H.HARA
  • Organizer: Neuroscience 2009
  • Place of Presentation: Chicago, USA
• [Presentation] 脂肪酸結合タンパク質によるドパミンD2受容体機能調節 (2009)
  • Author(s): 塩田倫史、山本由似、大和田祐二、福永浩司
  • Organizer: 第37回薬物活性シンポジウム
  • Place of Presentation: 仙台
• [Presentation] マウス大脳皮質初代培養ニューロンにおけるセロトニンによるCREBリン酸化反応 (2009)
  • Author(s): 笠原二郎、大村幸司、福永浩司
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] スパイン形成および記憶におけるジアシルグリセロールキナーゼβの重要性 (2009)
  • Author(s): 白井康仁、上月健、掛札賢一、大八木篤、堀江恭二、森口茂樹、嶋澤雅光、福永浩司、竹田潤二、齊藤尚亮、原英彰
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] CaMKキナーゼII活性化と2型Na+/Ca2+交換体による認知機能調節の関連性. (2009)
  • Author(s): 森口茂樹、韓峰、塩田倫史、喜多紗斗美、岩本隆宏、福永浩司
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] PDGF-β遺伝子欠損マウスにおいて海馬スパインとシナプス可塑性の異常は記憶障害を引き起こす. (2009)
  • Author(s): 塩田倫史、森口茂樹、山本由似、松島貴子、笹原正清、福永浩司
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Nobiletion-induced stimulation of CaMKII and CREB phosphoryl ation is associated with memory improvement after brain ischemia. (2009)
  • Author(s): Y Yamamoto, N Shioda, F Han, S Moriguchi, N akira, YA, Mimaki Y, Sashida Y, Yamakuni T, Ohizumi Y, K Fukunaga
  • Organizer: 22nd ISN/APSN joint meeting
  • Place of Presentation: Busan, Korea
• [Presentation] Aberrant CaMKII activity is associated with abnormal dendric spine formation via racl-GEF/PAK signaling in ATRX mutant mice. (2009)
  • Author(s): Norifumi Shioda, Beppu Hideyuki, Kitajima Isao, Kohji Fukunaga
  • Organizer: 22nd ISN/APSN joint meeting
  • Place of Presentation: Busan, Korea
• [Presentation] Deficient of memory formation mediated by impairment of intracelluar calcium homeostasis in neuronal junctophilin deficit mice. (2009)
  • Author(s): Shigeki Moriguchi, Takeshima Hiroshi, Kohji Fukunaga
  • Organizer: 22nd ISN/APSN joint meeting
  • Place of Presentation: Busan, Korea
• [Presentation] Novel strategy for promotion of neurogenesis to improve memory deficits after brain ischemia. (2009)
  • Author(s): Kohji Fukunaga, Norifumi Shioda
  • Organizer: 22nd ISN/APSN joint meeting
  • Place of Presentation: Busan, Korea
• [Presentation] 心臓型脂肪酸結合蛋白質はドパミン神経活動を調節する. (2009)
  • Author(s): 山本由似、塩田倫史、大和田祐二、福永浩司
  • Organizer: 第20回霧島神経薬理フォーラム
  • Place of Presentation: 鹿児島
• [Presentation] Stimulation of sigma-1 receptor signaling by dehydroepiandrosterone protects heart and kidney from pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats. (2009)
  • Author(s): Md.Shenuarin, Bhuiyan, Kohji Fukunaga
  • Organizer: Basic cardiovascular sciences conference 2009 Molecular mechanisms of cardiovascular disease
  • Place of Presentation: Lake Las Vegas, Nevada, U.S.A.
• [Presentation] BSRP欠損マウス扁桃体におけるCaMKII活性亢進と恐怖条件付け学習障害との関連性 (2009)
  • Author(s): 生野達也、森口茂樹、竹島浩、福永浩司
  • Organizer: 第11回ブレインサイエンス
  • Place of Presentation: 福岡
• [Presentation] Nefiracetamによる興奮性および抑制性神経伝達は、ニコチン性アセチルコリン受容体により制御される. (2009)
  • Author(s): 森口茂樹、楢橋敏夫、福永浩司
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬
• [Presentation] シナプス可塑性における神経活動依存的CaMKII活性化の役割. (2009)
  • Author(s): 福永浩司
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬
• [Presentation] クロマチンリモデリング因子ATRX変異精神遅滞モデルマウスにおけるスパイン形成異常とそのメカニズム (2009)
  • Author(s): 塩田倫史、別府秀幸、北島勲、福永浩司
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬
• [Presentation] Endothelial Nitric Oxide Synthase Regulation in Pressure Overload-Induced Hypertrophy in Ovariectomized Rats. (2009)
  • Author(s): Md.Shenuarin, Bhuiyan, Kohji Fukunaga
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: Sendai, Japan
• [Presentation] Pathophysiological Relevance of Uncoupled Endothelial Nitric Oxide Synthase in Cardiomyocyte Injury Triggered by Phenylephrine-induced Hypertrophy. (2009)
  • Author(s): Ying-Mei Lu, Norifumi Shioda, Kohji Fukunaga
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: Sendai, Japan
• [Presentation] Cell Surface Expression of Histamine H3 Receptor is Regulated by Proteins Interacting with the Carboxy-terminus of the Receptor. (2009)
  • Author(s): Kazuki Kinoshita, Shiori Takayanagi, Takeya Sato, Kay Maeda, Mituya Haraguchi, Kazuhiro Yanai, Kohji Fukunaga, Teruyuki Yanagisawa, Jun Sukegawa
  • Organizer: 10th International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: Sendai, Japan
• [Presentation] 脂肪酸結合蛋白質によるドパミン神経活動調節機構 (2009)
  • Author(s): 山本由似、塩田倫史、大和田祐二、福永浩司
  • Organizer: 第10回Pharmaco-Hematologyシンポジウム
  • Place of Presentation: 東京
• [Presentation] Akt-mediated eNOS activation prevents myocardial hypertrophic responses. (2009)
  • Author(s): Md.Shenuarin, Bhuiyan, Kohji Fukunaga
  • Organizer: 第9回日本NO学会学術集会
  • Place of Presentation: 静岡
• [Presentation] CaMK IIの活性異常は精神遅滞モデルマウスにおけるスパイン形態異常に関与する (2009)
  • Author(s): 塩田倫史、別府秀幸、北島勲、福永浩司
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(口演)
• [Presentation] 心臓型脂肪酸結合蛋白質欠損マウスの神経薬理学的表現型 (2009)
  • Author(s): 山本由似、本橋慧樹、塩田倫史、大和田祐二、福永浩司
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(口演)
• [Presentation] 脂肪酸結令蛋自質によるドパミンD2受容体の新しい機能制御 (2009)
  • Author(s): 福永浩司、侮田倫史、佃本由似、大和田祐二
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(シンポジウム)
• [Presentation] エンドセリン-1誘導による肥大心筋細胞におけるCaMKIIとカルシニューリンの新しいクロストーク (2009)
  • Author(s): Lu Yingmei、福永浩司
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(口演)
• [Presentation] Na+/Ca2+交換体欠損マウスにおける認知機能障害にはカルシウム/カルモデュリン依存性プロテインキナーゼIIの活性低下が関与する (2009)
  • Author(s): 森口茂樹、韓峰、塩田倫史、喜多紗斗美、小室一成、岩本隆宏、福永浩司
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(口演)
• [Presentation] Phosphorylation and activation of endothelial nitric oxide synthase by a vanadium (IV) compound ameliorates pressure overload-induced cardiac injury in ovariectomized female rats (2009)
  • Author(s): Md. Shenuarin, Bhuiyan、福永浩司
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(口演)
• [Presentation] 可溶性Fas-ligandは脳虚血における神経細胞死に関与する (2009)
  • Author(s): 塩田倫史、福永浩司
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(口演)
• [Presentation] フェニレフリンによる心筋障害における内皮型NOSの病態生理学的役割 (2009)
  • Author(s): 福永浩司、Ying-Mei LU、塩田倫史
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
• [Presentation] ドネペジルによるマウス中隔野アセチルコリン神経保護作用 (2009)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(学生シンポジウム)
• [Presentation] Na+/Ca2+交換体(NCX)による神経細胞内カルシウムと認知機能調節 (2008)
  • Author(s): 森口茂樹、韓峰、塩田倫更、喜多紗斗美、小室一成、岩本隆宏、福永浩司
  • Organizer: トランスポーターワークショップIN福岡
  • Place of Presentation: 福岡
  • Year and Date: 2008-11-02
• [Presentation] 精神遅滞関連遺伝子ATRX変異マウスのスパイン形成異常とそのメカニズム (2008)
  • Author(s): 塩田倫史、所崇、別府秀幸、北島勲、福永浩司
  • Organizer: 第47回日本薬学会東北支部大会
  • Place of Presentation: 岩手医科大学薬学部(口演)
  • Year and Date: 2008-10-26
• [Presentation] 嗅球摘出アウスにおけるDonepezilによるアセチルコリン神経保護作用 (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 第47回日本薬学会東北支部大会
  • Place of Presentation: 岩手医科大学薬学部(口演)
  • Year and Date: 2008-10-26
• [Presentation] 脳虚血におけるsoluble Fas-ligand発現と神経細胞死 (2008)
  • Author(s): 塩田倫史, 福永浩司
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台市情報・産業プラザ(口演)
  • Year and Date: 2008-09-27
• [Presentation] 嗅球摘出マウスにおけるドネペジルによるアセチルコリン神経保護作用 (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台市情報・産業プラザ(口演)
  • Year and Date: 2008-09-27
• [Presentation] ヒスタミンH3受容体の細胞表面発現作用 (2008)
  • Author(s): 木下和樹、高柳詩織、前田恵、原田満也、佐藤岳哉、谷内一彦、福永浩司、柳澤輝行、助川淳
  • Organizer: 第59回日本薬理学会北部会
  • Place of Presentation: 仙台市情報・産業プラザ(口演)
  • Year and Date: 2008-07-27
• [Presentation] クロマチンリモデリング蛋白質ATRX変異マウスのスパイン形成異常とそのメカニズム (2008)
  • Author(s): 塩田倫史、所崇、別府秀幸、北島勲、福永浩司
  • Organizer: 日本生化学会東北支部第74回例会・シンポジウム
  • Place of Presentation: アイーナ岩手県民情報交流センター(口演)
  • Year and Date: 2008-05-17
• [Presentation] 脳虚血に伴うCaMKII活性低下は学習記憶障害に関与している (2008)
  • Author(s): 山本由似、塩田倫史、森口茂樹、福永浩司
  • Organizer: 第10回ブレインサイエンス
  • Place of Presentation: マリンテラスあしや(口演)
• [Presentation] Activation of CaMKII mediates abnormal dendritic spine formation via Raci-GEF/PAK signaling in ATRX mutant mouse brain (2008)
  • Author(s): Norifumi Shioda, Takashi Tokoro, Hideyuki Beppu, Isao Kitajima and, Kohji Fukunaga
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォトラム
• [Presentation] ラット大脳皮質神経細胞の興奮性および抑制性神経伝達におけるガランタミンならびにネフィラセタムの効果 (2008)
  • Author(s): 森口茂樹、楢橋敏失、福永浩司
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] A novel cognitive enhancer rescues olfactory bulbectomy-induced memory impairment through stimulation of CaMKII and PKC sign alings in mouse hippocampus (2008)
  • Author(s): Fang Han, Norifumi Shioda, Shigeki Moriguchi, Yoshimasa Yamaguchi, Masataka Hino and Kohji Fukunaga
  • Organizer: International Conference on Alzheimer's Dis ease
  • Place of Presentation: Chicago USA
• [Presentation] The vanadium (IV) compound ameliorates OBX-induced neurodegene ration of the septo-hippocampal cholinergic neurons through Akt and ERK pathways (2008)
  • Author(s): Kohji Fukunaga, Feng Han, Shigeki Moriguchi and Norifumi Shioda
  • Organizer: International Conference on Alzheimer's Dis ease
  • Place of Presentation: Chicago USA
• [Presentation] Potentiation of calcium/calmodulin-dependent protein kinaSe II benefits for cognitive enhancement in Alzheimer's disease patients (2008)
  • Author(s): Shigeki Moriguchi, Fang Han, Norifumi Shioda, Toshio Narahashi and Kohji Fukunaga
  • Organizer: International Conference on Alzheimer's Disease
  • Place of Presentation: Chicago USA
• [Presentation] バナジウム化合物とメラトニンによるドパミン神経障害の保護効果Neuroprotective effect of a vanadium compound and melatonin in MPTP-induced dopaminergic defects in mice (2008)
  • Author(s): Jiro Kasahara, Tomofumi Nagai, Masatoshi Shibuya, Yoshiharu Iwabuchi, Norie Araki and Kohji Fukunaga
  • Organizer: 神経科学学会
  • Place of Presentation: 東京
• [Presentation] Fas/Fas-ligandのアポトーシスシグナル伝達は脳虚血による神経細胞死に関与する (2008)
  • Author(s): 塩田倫史、福永浩司
  • Organizer: 第19回霧島神経薬理フォーラム
  • Place of Presentation: 日本文理大学湯布院研修所(口演)
• [Presentation] アルツハイマー治療薬ドネペジルはアセチルコリン神経保護作用を有する (2008)
  • Author(s): 山本由似、塩田倫史、韓峰、森口茂樹、福永浩司
  • Organizer: 第19回霧島神経薬理フォーラム
  • Place of Presentation: 日本文理大学湯布院研修所(口演)
• [Presentation] Abnormal dendritic spine formation via CaMKII/Racl-GEF/PAK signaling in X-linked mental retardation model mouse (2008)
  • Author(s): Norifumi Shioda, Takashi Tokoro, Hideyuki Beppu, Isao Kitajima2 and Kohji Fuknnaga
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山国際会議場
• [Presentation] Impairment of cognitive function via down-regulation of calcium/calmodulin-dependent protein kinase II in Na+/Ca2+ exchanger (NCX2) knock-out mice (2008)
  • Author(s): Shigeki Moriguchi, Feng Han, Satomi Kita, Issei Komuro. Takahiro Iwamoto and Kohji Fukunaga
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山国際会議場
• [Presentation] A novel cognitive enhancer, ZSET1446 improves olfactory bulbectomy-induced memory impairment through CaMKII and PKC activation in mouse hippocampus (2008)
  • Author(s): Yui yamamoto, Feng Han, Norifumi Shioda, Shigeki Moriguchi, Kohji Fukunaga
  • Organizer: XI Workshop on Apoptosis in Biology and Medicine
  • Place of Presentation: Tohoku Pharmaceutical University(Poster)
• [Presentation] Deficit of methamphetamine-induced behavioral sensitization is associated with impaired CaM kinase II activity in neural jun ctophilin deficient mice (2008)
  • Author(s): Shigeki Moriguchi, Hiroshi Takeshima and Kohji Fukunaga
  • Organizer: 第38回日本神経精神薬理学会
  • Place of Presentation: 東京
• [Presentation] マウス中大脳動脈閉塞虚血におけるsoluble Fas ligandと神経細胞死 (2008)
  • Author(s): 塩田倫史, 福永浩司
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京ドームホテル
• [Presentation] 神経変性疾患と金属イオン (2008)
  • Author(s): 福永浩司
  • Organizer: 第1回メタロミクス研究フォーラムプログラム
  • Place of Presentation: 昭和女子大学学園本部館大会議室・中会議室(シンポジウム)