| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Research Abstract |
In this study, we have developed a novel compaction method of DNA using high hydrostatic pressure technology for gene delivery. It was founded that the compaction and secondary structure of DNA was controlled by the regulation of the high hydrostatic pressuring condition. When the compacted DNA by high hydrostatic pressure was applied for in vitro and in vivo transfection, the gene transcription and expression were delayed, suggesting that the controlled compaction of DNA by high hydrostatic pressurization would be regulate the transgene expression.
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