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Establishment of tools for assessing the effect of endocrine-disrupting chemicals on brain development in non-human primates

Research Project

Project/Area Number 20681005
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionAoyama Gakuin University

Principal Investigator

NEGISHI Takayuki  Aoyama Gakuin University, 理工学部, 助教 (80453489)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords内分泌かく乱物質 / カニクイザル / ラット / 甲状腺ホルモン / 水酸化PCB / 神経発達
Research Abstract

This study aimed to establish effective tools for assessing the effect of endocrine-disrupting chemicals on brain development in cynomolgus monkey, because cynomolgus monkey is phylogenetically close to human. This study revealed that development of inhibitory neurotransmission system delayed by systemic reduction of thyroid hormone induced by thyroid hormone synthesis inhibitor (methimazole) injection from three to 60 days after birth, when neural development dramatically proceeded. And this study established some in vitro tools using neural cells derived from cynomolgus monkey for assessing the effect of endocrine-disrupting chemicals on brain development

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (44 results)

All 2011 2010 2009 2008

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (29 results)

  • [Journal Article] Maternal plasma polychlorinated biphenyl levels in cynomolgus monkeys (Macaca fascicularis) affect infant social skills in mother-infant interaction.2011

    • Author(s)
      Nakagami A, Koyama T, Kawasaki K, Negishi T, Ihara T, Kuroda Y, Yoshikawa Y.
    • Journal Title

      Dev Psychobiol

      Volume: 53 Pages: 79-88

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal plasma polychlorinated biphenyl levels in cynomolgus monkeys (Macaca fascicularis) affect infant social skills in mother-infant interaction.2010

    • Author(s)
      Nakagami A, Koyama T, Kawasaki K, Negishi T, Ihara T, Kuroda Y, Yoshikawa Y.
    • Journal Title

      Developmental Psychobiology. 53

      Pages: 79-88

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Inhibitory Effects of TBT Chloride on the Development of F(1) Rats.2010

    • Author(s)
      Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y.
    • Journal Title

      Archives of Environmental Contamination and Toxicology. 58

      Pages: 1065-1073

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Inhibitory Effects of TBT Chloride on the Development of F(1) Rats.2010

    • Author(s)
      Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y.
    • Journal Title

      Arch Environ Contam Toxicol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynein dysfunction induces endocytic pathology accompanied by an increase in Rab GTPases : a potential mechanism underlying age-dependent endocytic dysfunction.2009

    • Author(s)
      Kimura N, Inoue M, Okabayashi S, Ono F, Negishi T.
    • Journal Title

      Journal of Biological Chemistry. 284

      Pages: 31291-31302

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period.2009

    • Author(s)
      Nakagami A, Negishi T (equal first-author), Kawasaki K, Imai N, Nishida Y, Ihara T, Kuroda Y, Yoshikawa Y, Koyama T.
    • Journal Title

      Psychoneuroendocrinology. 34

      Pages: 1189-1197

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in gene expression of glutamate receptors and exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat brain.2009

    • Author(s)
      Takahashi M, Negishi T, Imamura M, Sawano E, Kuroda Y, Yoshikawa Y, Tashiro T.
    • Journal Title

      Toxicology. 257

      Pages: 17-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynein dysfunction induces endocytic pathology accompanied by an increase in Rab GTPases : a potential mechanism underlying age-dependent endocytic dysfunction.2009

    • Author(s)
      Kimura N, Inoue M, Okabayashi S, Ono F, Negishi T.
    • Journal Title

      J Biol Chem 284

      Pages: 31291-302

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period.2009

    • Author(s)
      Nakagami A, Negishi T, Kawasaki K, Imai N, Nishida Y, Ihara T, Kuroda Y, Yoshikawa Y, Koyama T.
    • Journal Title

      Psychoneuroendocrinology 34

      Pages: 1189-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in male infant behaviors towards its mother by prenatal exposure to bisphenol A in cynomolgus monkeys (Macaca fascicularis) during early suckling period2009

    • Author(s)
      Nakagami A, Negishi T, Kawasaki K, Imai N, Nishida Y, Ihara T, Kuroda Y, Yoshikawa Y, Kovama T.
    • Journal Title

      Psychoneuroendocrinology (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and Excretion of Arsenic in Cynomolgus Monkey Following Repeated Administration of Diphenylarsinic Acid.2008

    • Author(s)
      Kobayashi Y, Negishi T, Mizumura A, Watanabe T, Hirano S.
    • Journal Title

      Archives of Toxicology. 82

      Pages: 553-561

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genes mediating thyroid hormone action in the developing mouse cerebellum.2008

    • Author(s)
      Takahashi M, Negishi T, Tashiro T.
    • Journal Title

      Journal of Neurochemistry. 104

      Pages: 640-652

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic manipulation of brain cultures from the primates : a novel tool for molecular studies of neuropsychiatric disorders.2008

    • Author(s)
      Yasumoto F, Hayashi A, Kamiya A, Negishi T, Yoshikawa Y, Sawa A.
    • Journal Title

      Molecular Psychiatry. 13

      Pages: 116-118

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and excretion of arsenic in cynomolgus monkey following repeated administration of diphenylarsinic acid2008

    • Author(s)
      Kobayashi Y, Negishi T, Mizumura A, Watanabe T, Hirano S.
    • Journal Title

      Archives of Toxicology 82

      Pages: 553-561

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in gene expression of glutamate receptors anc exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat Brain2008

    • Author(s)
      Takahashi M, Negishi T, Imamura M, Sawano E, Kuroda Y, Yoshikawa Y, Tashiro T.
    • Journal Title

      Toxicology 257

      Pages: 17-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] THE EFFECT OF PRENATAL EXPOSURE TO ENDOCRINE DISRUPTING CHEMICALS (EDCS) ON THE DEVELOPMENT OF MACAQUE SOCIALIZATION.2010

    • Author(s)
      Nakagami A, Negishi T, Kawasaki K, Kuroda Y, Yoshikawa Y, Koyama T.
    • Organizer
      International Primatological Society XXIII Congress Kyoto 2010
    • Place of Presentation
      Kyoto University, Kyoto, Japan
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effects of thyroid hormone on the survival and neurite outgrowth of cultured cerebellar granule cells2010

    • Author(s)
      K.Oyanagi, T.Negishi, T.Tashiro
    • Organizer
      The 10th biennial meeting of the ASIA-PACIFIC SOCIETY FOR NEUROCHEMISTRY
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Investigation of cerebral development in cynomolgus monkey - Histological and biochemical analyses2010

    • Author(s)
      T.Negishi, K.Oyanagi, M.Takahashi, N.Imai, T.Ihara, T.Tashiro
    • Organizer
      The 10th biennial meeting of the ASIA-PACIFIC SOCIETY FOR NEUROCHEMISTRY
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Local thyroid hormone matabolism in the hippocampus of senescence-accelerated SAMP8 mice2010

    • Author(s)
      E.Sawano, T.Negishi, T.Tashiro
    • Organizer
      The 10th biennial meeting of the ASIA-PACIFIC SOCIETY FOR NEUROCHEMISTRY
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of gene expression profiles in the hippocampus and cerebellum of the Goto-Kakizaki rat, an animal model of type 2 diabetes2010

    • Author(s)
      T.Uno, Y.Ishibashi, M.Takahashi, T.Negishi, T.Tashiro
    • Organizer
      The 10th biennial meeting of the ASIA-PACIFIC SOCIETY FOR NEUROCHEMISTRY
    • Place of Presentation
      Phuket, Thailand
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Investigation of cerebral development in cynomolgus monkey-Histological and biochemical analyses2010

    • Author(s)
      T.Negishi, K.Oyanagi, M.Takahashi, N.Imai, T.Ihara, T.Tashiro
    • Organizer
      The 10th biennial meeting of the ASIA-PACIFIC SOCIETY FOR NEUROCHEMISTRY
    • Place of Presentation
      Phuket, Thaiand
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Local thyroid hormone matabolism in the hippocampus of senescence-accelerated SAMP8 mice2010

    • Author(s)
      E.Sawano, T.Negishi, T.Tashiro
    • Organizer
      The 10th biennial meeting of the ASIA-PACIFIC SOCIETY FOR NEUROCHEMISTRY
    • Place of Presentation
      Phuket, Thaiand
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diphenylarsinic acid induced oxidative stress and expression of neuroactive and vasoactive peptides in cerebellar astrocytes2010

    • Author(s)
      Takayuki Negishi, Masaki Takahashi, Kohshi Oyanagi, Hiroaki Ohnishi, Seishiro Hirano, Tomoko Tashiro
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸、神戸コンベンションセンター(国際会議場・国際展示場)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Perinatal exposure affects the sensitivity to TBT neurotoxicity after maturation : evaluation by gene expression and behavioral analyses2010

    • Author(s)
      Masashi Tsunoda, Yuki Takeuchi, Ryousuke Yoshioka, Takayuki Negishi, Ryutaro Ikeuchi, Takaya Kaido, Mayuko Hosokawa, Chiemi Sugaya, Tomoko Tashiro, Yoshiharu Aizawa
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸、神戸コンベンションセンター(国際会議場・国際展示場)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Diphenylarsinic acid induced oxidative stress and expression of neuroactive and vasoactive peptides in cerebellar astrocytes2010

    • Author(s)
      Takayuki Negishi, Masaki Takahashi, Kohshi Oyanagi, Hiroaki Ohnishi, Seishiro Hirano, Tomoko Tashiro
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Perinatal exposure affects the sensitivity to TBT neurotoxicity after maturation : evaluation by gene expression and behavioral analyses2010

    • Author(s)
      Masashi Tsunoda, Yuki Takeuchi, Ryousuke Yoshioka, Takayuki Negishi, Ryutaro Ikeuchi, Takaya Kaido, Mayuko Hosokawa, Chiemi Sugaya, Tomoko Tashiro, Yoshiharu Aizawa
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Non-genomic action of Thyroxine (T4) on survival and neurite outgrowth of cerebellar granule cells in culture2010

    • Author(s)
      Koshi Oyanagi, Takayuki Negishi, Tomoko Tashiro
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸、神戸コンベンションセンター(国際会議場・国際展示場)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Alterations in local thyroid hormone metabolism in the hippocampus of senescence-accelerated SAMP8 mice2010

    • Author(s)
      Erika Sawano, Takayuki Negishi, Tomoko Tashiro
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸、神戸コンベンションセンター(国際会議場・国際展示場)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Non-genomic action of Thyroxine (T4) on survival and neurite outgrowth of cerebellar granule cells in culture2010

    • Author(s)
      Koshi Oyanagi, Takayuki Negishi, Tomoko Tashiro
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alterations in local thyroid hormone metabolism in the hippocampus of senescence-accelerated SAMP8 mice2010

    • Author(s)
      Erika Sawano, Takayuki Negishi, Tomoko Tashiro
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Traffic Jam hypothesis: dynein dysfunction causes endocytic pathology leading to intracellular Aβaccumulation.2010

    • Author(s)
      Nobuyuki Kimura, Makoto Inoue, Sachi Okabayashi, Fumiko Ono, Takayuki Negishi
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸、神戸コンベンションセンター(国際会議場・国際展示場)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Traffic Jam hypothesis : dynein dysfunction causes endocytic pathology leading to intracellular Assaccumulation.2010

    • Author(s)
      Nobuyuki Kimura, Makoto Inoue, Sachi Okabayashi, Fumiko Ono, Takayuki Negishi
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] サル類の行動を指標とした胎生期化学物質曝露による神経発達毒性の評価2009

    • Author(s)
      根岸隆之
    • Organizer
      第49回日本先天異常学会
    • Place of Presentation
      鹿児島県、鹿児島市民文化ホール
    • Year and Date
      2009-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] サル類の行動を指標とした胎生期化学物質曝露による神経発達毒性の評価2009

    • Author(s)
      根岸隆之
    • Organizer
      第49回日本先天異常学会
    • Place of Presentation
      鹿児島市民文化ホール
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット脳の発達に対するトリブチルスズ曝露の影響に関する二世代トキシコジェノミック研究2009

    • Author(s)
      角田正史、若佐美佳、浅川秀雄、高橋理貴、根岸隆之、峡戸孝也、細川まゆ子、菅谷ちえ美、井上葉子、相澤好治、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      群馬県、伊香保温泉
    • Year and Date
      2009-06-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 小脳顆粒細胞におけるジフェニルアルシン酸による酸化ストレスと細胞死2009

    • Author(s)
      根岸隆之、高橋理貴、小柳洸志、大西大空、平野靖史郎、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      群馬県、伊香保温泉
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 培養小脳顆粒細胞における低カリウム誘発細胞死に対する甲状腺ホルモンT4の細胞保護作用2009

    • Author(s)
      小柳洸志、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      群馬県、伊香保温泉
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] GABA神経伝達機構の発達における甲状腺ホルモンの役割2009

    • Author(s)
      澤野恵梨香、高橋理貴、船津尚子、木村洋人、根岸隆之、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      群馬県、伊香保温泉
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 2型糖尿病モデル・GKラットの脳におけるホモシステイン代謝の変化2009

    • Author(s)
      宇野健史、石橋瑛、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第52回日本神経化学会
    • Place of Presentation
      群馬県、伊香保温泉
    • Year and Date
      2009-06-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] メチマゾール短期曝露カニクイザル胎児における脳の組織学的検索2008

    • Author(s)
      豊島祐次郎、根岸隆之、伊原敏夫、吉川泰弘
    • Organizer
      第146回日本獣医学会
    • Place of Presentation
      宮崎県、シーガイア・ワールドコンベンションセンター・サミット
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 初代培養ラット小脳顆粒細胞における低カリウム誘発細胞死に対する内因性グルタミン酸の役割2008

    • Author(s)
      小柳洸志、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山県、富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] トリブチルスズ経世代曝露による発達期脳の遺伝子発現変化2008

    • Author(s)
      若佐美佳、今村誠、吉岡良祐、高橋理貴、根岸隆之、角田正、相澤好治、田代英夫、田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山県、富山国際会議場
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 初代培養ラット小脳顆粒細胞における低カリウム誘発細胞死に対する内因性グルタミン酸の役割2008

    • Author(s)
      小柳洸志、高橋理貴、根岸隆之、田代朋子
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] LPS誘導末梢性炎症による脳内甲状腺ホルモンシステムの変化2008

    • Author(s)
      高橋理貴、根岸隆之、澤野恵梨香、田代朋子
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山県、富山国際会議場
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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