Establishment of tools for assessing the effect of endocrine-disrupting chemicals on brain development in non-human primates
| Project/Area Number |
20681005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Aoyama Gakuin University |
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Principal Investigator |
NEGISHI Takayuki Aoyama Gakuin University, 理工学部, 助教 (80453489)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 内分泌かく乱物質 / カニクイザル / ラット / 甲状腺ホルモン / 水酸化PCB / 神経発達 |
|---|
| Research Abstract |
This study aimed to establish effective tools for assessing the effect of endocrine-disrupting chemicals on brain development in cynomolgus monkey, because cynomolgus monkey is phylogenetically close to human. This study revealed that development of inhibitory neurotransmission system delayed by systemic reduction of thyroid hormone induced by thyroid hormone synthesis inhibitor (methimazole) injection from three to 60 days after birth, when neural development dramatically proceeded. And this study established some in vitro tools using neural cells derived from cynomolgus monkey for assessing the effect of endocrine-disrupting chemicals on brain development
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Enhanced Inhibitory Effects of TBT Chloride on the Development of F(1) Rats.2010
Author(s)
Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y.
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Journal Title
Archives of Environmental Contamination and Toxicology. 58
Pages: 1065-1073
Related Report
Peer Reviewed
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[Journal Article] Enhanced Inhibitory Effects of TBT Chloride on the Development of F(1) Rats.2010
Author(s)
Asakawa H, Tsunoda M, Kaido T, Hosokawa M, Sugaya C, Inoue Y, Kudo Y, Satoh T, Katagiri H, Akita H, Saji M, Wakasa M, Negishi T, Tashiro T, Aizawa Y.
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Journal Title
Arch Environ Contam Toxicol (In press)
Related Report
Peer Reviewed
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