Creation of the 2nd generation peptide aptamer which dynamically controls interface between biomolecule and inorganic surface.
| Project/Area Number |
20681013
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SANO Ken-ichi The Institute of Physical and Chemical Research, 分子情報生命科学特別研究ユニット, 副ユニットリーダー (80321769)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | ナノバイオ / 分子認識 / ナノ・マイクロデバイス / バイオテクノロジー / アプタマー / ソフト界面 / 蛋白質 / 動的分子素子 / アプタマ |
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| Research Abstract |
The present study aims at the creation of a biomolecular element that achieves the dynamic control of binding and the unbinding between an artificial peptide and an inorganic material. I succeeded in making the phage library where the Zn-finger motif frame to screen by combinatorial engineering for the 2nd generation peptide aptamer. I also successfully analyzed in a detailed interfacial structure between a peptide aptamer and inorganic surface. Based on this structure, the design synthesis of the artificial peptide and the artificial protein was carried out.
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Report
(4 results)
Research Products
(50 results)
