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The development of therapy of pancreatic cancer stem cells and the surrounding stromal cells.

Research Project

Project/Area Number 20689026
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

OHUCHIDA Kenoki  九州大学, 医学研究院, 客員助教 (20452708)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords癌幹細胞 / 膵癌 / ニッチ / 癌間質相互作用 / 治療抵抗性 / 膵星細胞 / CD133 / 定量的RT-P / CD24 / 間質細胞 / 定量的RT-PCR
Research Abstract

In the present study, we investigated the pancreatic cancer stem cells and the surrounding stromal cells and found that a specific cell population of stromal cells, CD10 positive pancreatic stellate cells, have an important role in the cancer-stromal interaction during pancreatic cancer progression. We also investigated the mechanisms of the promoting effects of CD10 positive cells on the enhancement of invasion of pancreatic cancer cells, and found that MMP3 is implicated in this mechanism. These data suggest that there is heterogeneity among pancreatic stellate cells and a specific subpopulation of these cells has more important role in cancer progression.

Report

(5 results)
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (62 results)

All 2011 2010 2009 2008 Other

All Journal Article (32 results) (of which Peer Reviewed: 4 results) Presentation (21 results) Book (9 results)

  • [Journal Article] Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka2011

    • Author(s)
      Hayato Fujita, Kenoki Ohuchida*, Kazuhiro Mizumoto, Soichi Itaba, Tetsuhide Ito, Kohei Nakata, Jun Yu, Tadashi Kayashima, Akifumi Hayashi, Ryota Souzaki, Tatsuro Tajiri
    • Journal Title

      Masao Tanaka High EGFR mRNA Expression Level is a Prognostic Factor for Reduced Survival in Pancreatic Cancer after Gemcitabine-based Adjuvant Chemotherapy International Journal of Oncology

      Volume: 38 Pages: 629-41

    • Related Report
      2010 Final Research Report
  • [Journal Article] Masao Tanakaα-SMA expressing stroma promotes an aggressive tumor-biology in pancreatic ductal adenocarcinoma2010

    • Author(s)
      Hayato Fujita, Kenoki Ohuchida*, Kazuhiro Mizumoto, Kohei Nakata, Jun Yu, Tadashi Kayashima, Manabe Tatsuya, Ohtsuka Takao
    • Journal Title

      Pancreas

      Volume: 39 Pages: 1254-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] MicroRNA-203 expression is a new prognostic marker of pancreatic cancer2010

    • Author(s)
      Naoki Ikenaga, Kenoki Ohuchida*, Kazuhiro Mizumoto, Jun Yu, Tadashi Kayashima, Hayato Fujita, Kohei Nakata and Masao Tanaka
    • Journal Title

      MicroRNA-203 expression is a new prognostic marker of pancreatic cancer

      Volume: 17 Pages: 3120-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression Analyses in Preoperative Pancreatic Juice Samples of Pancreatic Ductal Adenocarcinoma2010

    • Author(s)
      Sadakari Y, Ohtsuka T, Ohuchida K, Tsutsumi K, Takahata S, Nakamura M, Mizumoto K, Tanaka M. MicroRNA
    • Journal Title

      JOP

      Volume: 11 Pages: 587-92

    • Related Report
      2010 Final Research Report
  • [Journal Article] Masao Tanaka MicroRNA miR-17-5p is overexpressed in pancreatic cancer, and its upregulation enhances cancer cell proliferation and invasion in vitro2010

    • Author(s)
      Jun Yu, Kenoki Ohuchida*, Kazuhiro Mizumoto, Hayato Fujita, Kouhei Nakata and Masao Tanaka
    • Journal Title

      Cancer Biology & Therapy

      Volume: 10 Pages: 748-57

    • Related Report
      2010 Final Research Report
  • [Journal Article] Takao Ohtsuka, Masao Tanaka Gene Expression levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-based adjuvant Chemotherapy2010

    • Author(s)
      Hayato Fujita, Kenoki Ohuchida*, Kazuhiro Mizumoto, Soichi Itaba, Tetsuhide Ito, Kohei Nakata, Jun Yu, Tadashi Kayashima, Ryota Souzaki, Tatsuro Tajiri, Tatsuya Manabe
    • Journal Title

      Neoplasia

      Volume: 12 Pages: 801-17

    • Related Report
      2010 Final Research Report
  • [Journal Article] Masao Tanaka Prospectively isolated2010

    • Author(s)
      Lin Cui, Kenoki Ohuchida*, Kazuhiro Mizumoto, Taiki Moriyama, Manabu Onimaru, Kohei Nakata, Toshinaga Nabae, Takashi Ueki, Norihiro Sato, Yohei Tominaga
    • Journal Title

      PLos One

      Volume: 12 Pages: 12121-12121

    • Related Report
      2010 Final Research Report
  • [Journal Article] CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer2010

    • Author(s)
      Naoki Ikenaga, Kenoki Ohuchida*, Kazuhiro Mizumoto, Lin Cui, Tadashi Kayashima, Katsuya Morimatsu, Taiki Moriyama, Kohei Nakata, Hayato Fujita, and Masao Tanaka
    • Journal Title

      Gastroenterology

      Volume: 139 Pages: 1041-51

    • Related Report
      2010 Final Research Report
  • [Journal Article] MicroRNA hsa-miR-200c is an independent prognostic factor in pancreatic cancer, and its upregulation inhibits pancreatic cancer invasion, but increases cell proliferation2010

    • Author(s)
      Jun Yu, Kenoki Ohuchida*, Kazuhiro Mizumoto*, Norihiro Sato, Tadashi Kayashima, Hayato Fujita, Kouhei Nakata, and Masao Tanaka
    • Journal Title

      Molecular Cancer

      Volume: 28 Pages: 9-169

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of CD24 expression in intraductal papillary mucinous neoplasms and pancreatic cancer2010

    • Author(s)
      Naoki Ikenaga, Kenoki Ohuchida*, Kazuhiro Mizumoto, Jun Yu, Tadashi Kayashima, Akifumi Hayashi, Kohei Nakata, and Masao Tanaka
    • Journal Title

      Human Pathology

      Volume: 41 Pages: 1466-74

    • Related Report
      2010 Final Research Report
  • [Journal Article] S100P is a novel marker to identify invasive lesion in intraductal papillary mucinous neoplasms2010

    • Author(s)
      Kohei Nakata, Eishi Nagai, Kenoki Ohuchida, Shinichi Aishima, Akifumi Hayashi, Yoshihiro Miyasaka, Jun Yu, Kazuhiro Mizumoto, Masao Tanaka, and Masazumi Tsuneyoshi
    • Journal Title

      Human Pathology

      Volume: 41 Pages: 824-31

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effectiveness of basic endoscopic surgical skill training for pediatric surgeons2010

    • Author(s)
      Ieiri S, Nakatsuji T, Higashi M, Akiyoshi J, Uemura M, Konishi K, Onimaru M, Ohuchida Kenoki, Hong J, Tomikawa M, Tanoue K, Hashizume M, Taguchi T
    • Journal Title

      Pediatr Surg Int

      Volume: 26 Pages: 947-54

    • Related Report
      2010 Final Research Report
  • [Journal Article] Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derivedfrom the intestinal type2010

    • Author(s)
      Yoshihiko Sadakari, Kenoki Ohuchida, Kohei Nakata, Tadashi Kayashima, Shinichi Aishima, Shunichi Takahata, Masafumi Nakamura, Kazuhiro Mizumoto, and Masao Tanaka
    • Journal Title

      Surgery

      Volume: 147 Pages: 812-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells2010

    • Author(s)
      Taiki Moriyama, Kenoki Ohuchida*, Kazuhiro Mizumoto, Lin Cui, Naoki Ikenaga, Norihiro Sato, and Masao Tanaka
    • Journal Title

      Cancer

      Volume: 116 Pages: 3357-68

    • Related Report
      2010 Final Research Report
  • [Journal Article] synergistically enhances the effects of adenovirus gene therapy via activation of the CMV promoter in pancreatic cancer cells2010

    • Author(s)
      Manabu Onimaru, Kenoki Ohuchida*, Takuya Egami, Kazuhiro Mizumoto, Eishi Nagai, Lin Cui, Hiroki Toma, Kunio Matsumoto, Makoto Hashizume, and Masao Tanaka Gemcitabine
    • Journal Title

      Cancer Gene Therapy

      Volume: 17 Pages: 541-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gemcitabine synergistically enhances cytotoxicity of hTERT promoter-dependent conditionally replicative adenovirus in pancreatic cancer cells2010

    • Author(s)
      Manabu Onimaru, Kenoki Ohuchida*, Eishi Nagai, Kazuhiro Mizumoto, Takuya Egami, Lin Cui, Norihiro Sato, Junji Uchino, Koichi Takayama, Makoto Hashizume, Masao Tanaka
    • Journal Title

      Cancer Letter

      Volume: 294 Pages: 178-86

    • Related Report
      2010 Final Research Report
  • [Journal Article] hTERT-promoter dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells2010

    • Author(s)
      Onimaru Manabu, Ohuchida Kenoki*, Mizumoto Kazuhiro, Nagai Eishi, Cui Lin, Toma Hiroki, Takayama Koichi, Matsumoto Kunio, Hashizume Makoto, Tanaka Masao
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 735-42

    • NAID

      10026589785

    • Related Report
      2010 Final Research Report
  • [Journal Article] SPARC mRNA Expression as a prognostic Marker for pancreatic adenocarcinoma patients2010

    • Author(s)
      Kei Miyoshi, Norihiro Sato, Kenoki Ohuchida, Kazuhiro Mizumoto and MasaoTanaka
    • Journal Title

      Anticancer Research

      Volume: 30 Pages: 867-71

    • Related Report
      2010 Final Research Report
  • [Journal Article] assessment using a virtual reality simulator, LapSim, after training to develop fundamental skills for endoscopic surgery2010

    • Author(s)
      Tanoue K, Uemura M, Kenmotsu H, Ieiri S, Konishi K, Ohuchida Kenoki, Onimaru M, Nagao Y, Kumashiro R, Tomikawa M, Hashizume M. Skills
    • Journal Title

      Minim Invasive Ther Allied Technol

      Volume: 9 Pages: 24-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] Masao Tanaka CD44v6 Expression in Intraductal Papillary Mucinous2010

    • Author(s)
      Yoshihiro Miyasaka, Eishi Nagai, Kenoki Ohuchida, Kohei Nakata, Akifumi Hayashi, Kazuhiro Mizumoto, Masazumi Tsuneyoshi
    • Journal Title

      Neoplasms of the Pancreas Pancreas

      Volume: 39 Pages: 31-5

    • Related Report
      2010 Final Research Report
  • [Journal Article] CD10 pancreatic stellate cells enhance the progression of pancreatic cancer2010

    • Author(s)
      Ikenaga N, Ohuchida K, Mizumoto K, Cui L, Kayashima T, Morimatsu K, Moriyama T, Nakata K, Fujita H, Tanaka M
    • Journal Title

      Gastroenterology 139

      Pages: 1041-1051

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] Prospectively isolated cancer-associated CD10 (+) fibroblasts have stronger interactions with CD133 (+) colon cancer cells than with CD133 (-) cancer cells2010

    • Author(s)
      Cui L, Ohuchida K, Mizumoto K, Moriyama T, Onimaru M, Nakata K, Nabae T, Ueki T, Sato N, Tominaga Y, Tanaka M
    • Journal Title

      PLoS ONE 12

    • Related Report
      2010 Self-evaluation Report
  • [Journal Article] CD+10 Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer2010

    • Author(s)
      Ikenaga N, Ohuchida K, et al.
    • Journal Title

      Gastroenterology

      Volume: 139 Pages: 1041-1051

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospectively Isolated Cancer-Associated CD10+ Fibroblasts Have Stronger Interactions with CD133+ Colon Cancer Cells than with CD1332 Cancer Cells2010

    • Author(s)
      Cui L, Ohuchida K, et al.
    • Journal Title

      Plus One

      Volume: 5(CD-R)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵癌の分子生物学的解析に基づく個別化治療に向けた取り組み2010

    • Author(s)
      大内田研宙, 大塚隆生, 水元一博, 田中雅夫
    • Journal Title

      胆と膵 31

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 分子発現解析に基づく膵癌診断法とその意義2010

    • Author(s)
      大内田研宙, 大塚隆生, 水元一博, 田中雅夫
    • Journal Title

      膵臓 29

      Pages: 751-6

    • NAID

      10027054999

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells ; Evaluation with direct and indirect co-culture system2009

    • Author(s)
      Hayato Fujita, Kenoki Ohuchida*, Kazuhiro Mizumoto, Takuya Egami, Kei Miyoshi, Taiki Moriyama, Cui Lin, Jun Yu, Tatsuya Manabe, Masao Tanaka
    • Journal Title

      Cancer Science

      Volume: 100 Pages: 2309-17

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intraabdominal Roux-en-Y reconstruction with a novel stapling technique after laparoscopic distal gastrectomy2009

    • Author(s)
      Noshiro H, Kenoki Ohuchida, Kawamoto M, Ishikawa M, Uchiyama A, Shimizu S, Tanaka M
    • Journal Title

      Gastric Cancer

      Volume: 12 Pages: 164-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] MicroRNA-21(miR-21) modulates biologic functions of pancreatic cancer cells including their proliferation, invasion and chemoresistance2009

    • Author(s)
      Taiki Moriyama, Kenoki Ohuchida*, Kazuhiro Mizumoto, Jun Yu, Toshinaga Nabae, Shunichi Takahata, Norihiro Sato, Hiroki Toma, Eishi Nagai, and Masao Tanaka
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: 8 Pages: 1067-74

    • Related Report
      2010 Final Research Report
  • [Journal Article] S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma Journal of2009

    • Author(s)
      Naoki Ikenaga, Kenoki Ohuchida*, Kazuhiro Mizumoto, Jun Yu, Takuya Egami, Toshinaga Nabae, Junji Ueda, Norihiro Sato, Eishi Nagai, and Masao Tanaka
    • Journal Title

      Gastrointestinal Surgery

      Volume: 13 Pages: 1852-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Upregulation of integrin s3 in Radio-Resistant Pancreatic Cancer impair Adenovirus Gene Therapy2009

    • Author(s)
      Takuya Egami, Kenoki Ohuchida*, Takaharu Yasui, Kazuhiro Mizumoto, Manabu Onimaru, Hiroki Toma, Norihiro Sato, Kunio Matsumoto, and Masao Tanaka
    • Journal Title

      Cancer Science

      Volume: 100 Pages: 1902-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Enhanced cell migration and invasion of CD133^+ pancreatic cancer cells co-cultured with pancreatic stromal cells

    • Author(s)
      Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Lin Cui, Naoki Ikenaga, Norihiro Sato, Masao Tanaka
    • Journal Title

      Cancer (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 2011 at National Cheng Kung University2011

    • Author(s)
      The 4th International Conference for Treatment of Pancreatic Cancer Jun 25(Sat.)
    • Organizer
      Taiwan Title
    • Place of Presentation
      The functional heterogeneity of pancreatic cancer cells and surrounding stromal cells in tumor-stromal interaction
    • Year and Date
      2011-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Symposium 1 Kenoki Ohuchida Title2009

    • Author(s)
      The International Pancreatic Research forum 2009 Session
    • Organizer
      Clinical value of mRNA expression analysis in pancreatic juice Date & Time
    • Place of Presentation
      Venue : Hotel Pacific Tokyo
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Clinical value of mRNA expression analysis in pancreatic juice2009

    • Author(s)
      Kenoki Ohuchida
    • Organizer
      The International Pancreatic Research Forum 2009
    • Place of Presentation
      東京
    • Year and Date
      2009-03-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD10 positive pancreatic stellate cells enhance the progression of pancreatic cancer2009

    • Author(s)
      Ikenaga N, Ohuchida K, Mizumoto K, Tanaka M
    • Organizer
      40^<th> Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Association
    • Place of Presentation
      Hawaii
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] CD133^+ cells are resistant to anoikis in pancreatic cancer2009

    • Author(s)
      T.Moriyama, K.Ohuchida, C.Lin, N.Ikenaga, H.Sakai, K.Mizumoto, M.Tanaka
    • Organizer
      the Joint 40th Anniversary Meeting of American Pancreatic Association and Japan Pancreas Society
    • Place of Presentation
      米国(ハワイ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD10 positive pancreatic stellate cells enhance the progression of pancreatic cancer2009

    • Author(s)
      Naoki Ikenaga, Kenoki Ohuchida, Kazuhiro Mizumoto, Masao Tanaka
    • Organizer
      the Joint 40th Anniversary Meeting of American Pancreatic Association and Japan Pancreas Society
    • Place of Presentation
      米国(ハワイ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Trends and Prospects of the Treatment of Resectable Pancretic Cancer2009

    • Author(s)
      Kazuhiro Mizumoto, Kenoki Ohuchida, Hayato Fujita, Masao Tanaka
    • Organizer
      日本癌学会 シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Floating fibroblasts promote invasiveness of pancreatic cancer cells2009

    • Author(s)
      Lin Cui, Kenoki Ohuchida, Kazuhiro Mizumoto, Manabu Onimaru, Masao Tanaka
    • Organizer
      the Joint 40th Anniversary Meeting of American Pancreatic Association and Japan Pancreas Society
    • Place of Presentation
      米国(ハワイ)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵癌におけるCD133陽性細胞は、癌間質作用を介してより高い遊走・浸潤能を獲得する2009

    • Author(s)
      森山大樹, 大内田研宙, 水元一博, 崔林, 余俊, 江上拓哉, 藤田逸人, 佐藤典宏, 当間宏樹, 永井英司, 田中雅夫
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分子生物学的解析から膵癌診断、個別化治療へ向けて2009

    • Author(s)
      大内田研宙、水元一博、田中雅夫
    • Organizer
      第40回日本膵臓学会 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] CD133 positive cells in pancreatic cancer possess increased cell proliferation, migration and invasion2008

    • Author(s)
      Taiki Moriyama
    • Organizer
      American pancreatic association
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵癌細胞における癌幹細胞同定の試み〜GD133陽性細胞め遺伝子発現解析〜2008

    • Author(s)
      森山大樹
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in its Invasiveness possibly via Suppression of the HOXA1 gene Abstract No2008

    • Author(s)
      Kenoki Ohuchida, Kazuhiro Mizumoto, Taiki Moriyama, Shunichi Takahata, Hiroki Toma, Norihiro Sato, Eishi Nagai, and Masao Tanaka
    • Organizer
      08062 the 39th Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] CD133 positive cells in pancreatic cancer possess increased cell proliferation2008

    • Author(s)
      Taiki Moriyama, Kenoki Ohuchida, Kazuhiro Mizumoto, Cui Lin, Norihiro Sato, and Masao Tanaka
    • Organizer
      migration and invasion the 39th Annual Meeting of the American Pancreatic Association
    • Place of Presentation
      Chicago
    • Related Report
      2010 Self-evaluation Report 2010 Final Research Report
  • [Presentation] The enhanced effect of gemcitabine on the adenovirus-mediated gene therapy the 39th Annual2008

    • Author(s)
      M. Onimaru, K. Ohuchida, E. Nagai, K. Mizumoto, T. Egami, N. Sato, H. Toma, and M. Tanaka
    • Organizer
      Meeting of the American Pancreatic Association
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] Associated Fibrobalasts the 39th Annual2008

    • Author(s)
      K Miyoshi, Sato N, Ohuchida K, Mizumoto K, Tanaka M Epigenetic Changes in Pancreatic Cancer
    • Organizer
      Meeting of the American Pancreatic Association
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] TanakaGemcitabine synergistically enhances cytotoxicity of hTERT2008

    • Author(s)
      Manabu Onimaru, Eishi Nagai, Kenoki Ohuchida, Takuya Egami, Hayato Fujita, Taiki Moriyama, Kei Miyoshi, Jun Yu, Lin Cui, Shoko Nishio, Hiroki Toma, Norihiro Sato, Kazuhiro Mizumoto, Junji Uchino, Koichi Takayama, and Masao Tanaka
    • Organizer
      promoter-dependent conditionally replicative adenovirus in pancreatic cancer cells
    • Place of Presentation
      Pancreatology
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantitative analysis of hTERT mRNA levels in cells2008

    • Author(s)
      Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Takuya Egami, Yoshihiro Miyasaka, Hiroshi Yamaguchi, Masayuki Ohta, Jun Yu, Lin Cui, Shunichi Takahata, Masazumi Tsuneyoshi, Masao Tanaka
    • Organizer
      microdissected from cytological specimens
    • Place of Presentation
      International Association of Pancreatology
    • Related Report
      2010 Final Research Report
  • [Presentation] RegIV expression is involved in'Intestinal type2008

    • Author(s)
      Kohei Nakata, Eishi Nagai, Kenoki Ohuchida, Yoshihiro Miyasaka, Akifumi Hayashi, Kazuhiro Mizumoto, Masao Tanaka and Yoshizumi Tsuneyoshi
    • Organizer
      carcinogenesis of Intraductal papillary mucinous neoplasm of pancreas
    • Place of Presentation
      DDW
    • Related Report
      2010 Final Research Report
  • [Presentation] Micro RNA(miR-17-5p) is overexpressed in pancreatic cancer2008

    • Author(s)
      Jun Yu, Taiki Moriyama, Kenoki Ohuchida, Lin Cui, Norihiro Sato, Hiroki Toma, Shunichi Takahata, Eishi Nagai, Kazuhiro Mizumoto, and Masao Tanaka
    • Organizer
      and upregulation of miR-17-5p enhanced cancer cell proliferation and invasion in vitro
    • Place of Presentation
      DDW
    • Related Report
      2010 Final Research Report
  • [Presentation] Masazumi Tsuneyoshi Senescence in intraductal papillary mucinous neoplasms of the pancreas2008

    • Author(s)
      Yoshihiro Miyasaka ; Eishi Nagai ; Kenoki Ohuchida ; Kohei Nakata ; Akifumi Hayashi ; K Mizumoto ; Masao Tanaka
    • Place of Presentation
      DDW
    • Related Report
      2010 Final Research Report
  • [Book] 膵癌の分子生物学的解析の現状、腫瘍内科2011

    • Author(s)
      大内田研宙, 藤田逸人、水元一博、田中雅夫
    • Related Report
      2010 Final Research Report
  • [Book] 膵癌の分子生物学的解析の現状 7巻2号(腫瘍内科)2011

    • Author(s)
      藤田逸人、水元一博、田中雅夫
    • Publisher
      大内田研宇
    • Related Report
      2010 Self-evaluation Report
  • [Book] 特集/膵嚢胞性疾患の新展開、I.嚢胞性膵腫瘍の基礎2.分子生物マーカー:biomarker肝胆膵2010

    • Author(s)
      大内田研宙、水元一博、藤田逸人, 大塚隆生、田中雅夫
    • Related Report
      2010 Final Research Report
  • [Book] 膵癌の分子生物学的解析に基づく個別化治療に向けた取り組み、胆と膵2010

    • Author(s)
      大内田研宙, 大塚隆生, 水元一博, 田中雅夫
    • Related Report
      2010 Final Research Report
  • [Book] 2.分子発現解析に基づく膵癌診断法とその意義、特集「膵癌に対するトランスレーショナルリサーチの展望」2010

    • Author(s)
      大内田研宙, 大塚隆生, 水元一博, 田中雅夫
    • Related Report
      2010 Final Research Report
  • [Book] 特集/膵嚢胞性疾患の新展開I.嚢胞性膵腫瘍の基礎2.分子生物マーカー : biomarker肝胆膵 61巻3号2010

    • Author(s)
      水元一博、藤田逸人、大塚隆生、田中雅夫
    • Publisher
      大内田研宇
    • Related Report
      2010 Self-evaluation Report
  • [Book] 膵癌の分子生物学的解析に基づく個別化治療に向けた取り組み胆と膵 31巻4号2010

    • Author(s)
      大塚隆生 水元一博 田中雅夫
    • Publisher
      大内田研宇
    • Related Report
      2010 Self-evaluation Report
  • [Book] 『膵癌に対するトランスレーショナルリサーチの展望』膵臓 第25巻1号(分子発現解析に基づく膵癌診断法とその意義 特集)2010

    • Author(s)
      大塚隆生 水元一博 田中雅夫
    • Publisher
      大内田研宇
    • Related Report
      2010 Self-evaluation Report
  • [Book] 膵液中腫瘍マーカーと膵疾患 胆と膵 29巻8号2008

    • Author(s)
      水元一博 高畑俊一 許斐裕之 田中雅夫
    • Publisher
      大内田研宇
    • Related Report
      2010 Self-evaluation Report

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Published: 2008-04-01   Modified: 2016-04-21  

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