| Budget Amount *help |
¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Research Abstract |
In the present study, we investigated the pancreatic cancer stem cells and the surrounding stromal cells and found that a specific cell population of stromal cells, CD10 positive pancreatic stellate cells, have an important role in the cancer-stromal interaction during pancreatic cancer progression. We also investigated the mechanisms of the promoting effects of CD10 positive cells on the enhancement of invasion of pancreatic cancer cells, and found that MMP3 is implicated in this mechanism. These data suggest that there is heterogeneity among pancreatic stellate cells and a specific subpopulation of these cells has more important role in cancer progression.
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