| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
The mobility of the neurotransmitter receptors on the plasma membrane is one of the factors determining the efficacy of synaptic transmission. In this study, we found that the increase in GABA_A receptor lateral diffusion, which is induced by Ca^<2+> influx from the extracellular space and subsequent the activation of calcineurin, is the starting point of inhibitory synaptic plasticity. Our result also suggested the possibility that Ca^<2+> release from the intracellular Ca^<2+> store contributes to the inhibition of GABA_A receptor lateral diffusion through protein phosphorylation.
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