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Evaluation of carcinogenicity of rare metal nanoparticles using molecular biological methods

Research Project

Project/Area Number 20710027
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental impact assessment/Environmental policy
Research InstitutionKurume University

Principal Investigator

HASEGAWA Go  Kurume University, 医学部, 助教 (80383751)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsナノ粒子 / レアメタル / 健康影響 / 発癌
Research Abstract

Mutagenicity and transformation activity of four rare metals, In_2O_3, Dy_2O_3, WO_3 and Mo, were evaluated. The Ames test revealed that nano-sized Dy_2O_3, In_2O_3 and WO_3 possessed mutagenic potential. With the respect to the result of transformation assay, In_2O_3 and Dy_2O_3 also showed potential ability, although particle size of these rare metals did not affect to their transformation activity.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 2008

All Journal Article (2 results) Presentation (2 results) Book (3 results)

  • [Journal Article] 微小粒子状物質と心肺疾患2008

    • Author(s)
      石原陽子、柴田彰、長谷川豪
    • Journal Title

      呼吸と循環 56(8)

      Pages: 817-826

    • NAID

      40016163549

    • Related Report
      2010 Final Research Report
  • [Journal Article] 微小粒子状物質と心肺疾患2008

    • Author(s)
      石原陽子, 他
    • Journal Title

      呼吸と循環 56

      Pages: 817-826

    • Related Report
      2008 Annual Research Report
  • [Presentation] Mutagenicity of rare metal and metal oxide nanoparticles : components and particle sizes.2011

    • Author(s)
      Hasegawa G, Shimonaka M, Ishihara Y
    • Organizer
      Society for Toxicology 2011 Annual Meeting & ToxExpo
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-03-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Mutagenicity of rare metal and metal oxide nanoparticles : components and particle sizes2011

    • Author(s)
      Hasegawa G, et al.
    • Organizer
      Society for Toxicology 2011 Annual Meeting & ToxExpo
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2011-03-08
    • Related Report
      2010 Annual Research Report
  • [Book] ナノ材料のリスク評価と安全性対策(第2章ナノ材料の生体への影響 5.ナノ粒子の体内への取り込み経路、標的となる臓器とその影響)2010

    • Author(s)
      石原陽子、長谷川豪、小山哲史
    • Publisher
      フロンティア出版
    • Related Report
      2010 Final Research Report
  • [Book] ナノ材料のリスク評価と安全性対策 第2章ナノ材料の生体への影響 5.ナノ粒子の体内への取り込み経路、標的となる臓器とその影響2010

    • Author(s)
      石原陽子, 他
    • Total Pages
      317
    • Publisher
      フロンティア出版
    • Related Report
      2010 Annual Research Report
  • [Book] ナノ材料のリスク評価と安全性対策 第2章ナノ材料の生体への影響 5.ナノ粒子の体内への取り込み経路、標的となる臓器とその影響2010

    • Author(s)
      石原陽子, 他
    • Publisher
      フロンティア出版(印刷中)
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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