| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We developed more realistic molecular model of cell membranes and obtained their physical characters by conducting molecular simulations of cell membranes composed of different types of lipids and cholesterol. The application of shear stresses to the cell membrane model revealed, for example, that the inclusion of cholesterol hampers the thinning the membrane. Furthermore, we found that the water penetration into the membrane caused by such stresses can induce spontaneous formation of a pore structure in the membrane.
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