| Project/Area Number |
20770156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
NAKAMURA Nobuhiro Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教 (80361765)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞構造・機能 / ミトコンドリア / ユビキチン / 精子形成 / 脱ユビキチン化酵素 / 変異体 / ゼブラフィッシュ / 酵素活性 / RNAi / 細胞生物学 / ミトコンドリアダイナミクス / 精巣 |
|---|
| Research Abstract |
This study has demonstrated that 1) an enzymatic activity of human USP30, a novel mitochondrial deubiquitinating enzyme, is required for maintenance of mitochondrial morphology, and 2) mouse GGNBP1 is highly expressed in spermatogenic cells and induces Drp1-dependent mitochondrial fragmentation. These results provide better understand of the molecular mechanism of mitochondrial dynamics.
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