| Project/Area Number |
20780101
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
AKAGAWA Mitsugu Osaka Prefecture University, 生命環境科学研究科, 助教 (70405356)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Takeshi 静岡県立大学, 大学院・生活健康科学研究科, 助教 (50448700)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ポリフェノール / カテキン / 緑茶 / ガン / 蛋白質 / p68 / エピガロカテキンがレート / エピガロカテキンガレート / ミリセチン |
|---|
| Research Abstract |
In the present study, we searched for polyphenols that covalently bind to cellular proteins. A major green tea catechin, epigallocatechin-3-gallate (EGCG), was identified to bind to cellular proteins with high affinity. The regulation mechanism of protein function by the binding of EGCG was examined. We also identified cellular protein targets of EGCG in several functional categories including energy metabolism, glycolysis, chaperone, and RNA processing. The binding of EGCG to the target protein was suggested to be closely involved in anti-cancer effect of EGCG.
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