Role of interleukin-19 on the inflammatory bowel disease
| Project/Area Number |
20780209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
AZUMA Yasutaka Osaka Prefecture University, 生命環境科学研究科, 准教授 (50298816)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬理 / 粘膜免疫 / 炎症 / IL-19 / 炎症性腸疾患 / マクロファージ / TLR / サイトカイン |
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| Research Abstract |
We show that IL-19-deficient mice are more susceptible to experimental acute colitis induced by DSS, and this increased susceptibility is correlated with the accumulation of macrophages and the increased production of IFNγ, IL-1β, IL-6, IL-12, TNF-α and KC.
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Report
(3 results)
Research Products
(10 results)
