| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
To clarify the molecular mechanism of neurotoxicity induced by methylmercury, we investigated extracellular matrices and their degradation enzymes. In this study, we showed that methylmercury-activated matrix metalloproteinase MMP-2 cleaved neurocan, an extracellular proteoglycan. Then, we also indicated the occurrence of a soluble form of neuroglycan C, a transmembrane proteoglycan in rodent brain.
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