The strategy to avoid the side effect of lipid-lowering agents

• Project/Area Number: 20790126
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: KOBAYASHI Masaki Hokkaido University, 大学院・薬学研究院, 助教 (70431319)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 薬学 / 臨床 / 薬物相互作用 / トランスポータ / スタチン / ABCトランスポータ / LXR / 発現調節 / 高脂血症 / 肝臓 / 胆汁中排泄

Research Abstract

In this study, we focused on a nuclear receptor, LXR (liver X receptor) and examined the effect of statins, lipid-lowering agents, on LXR function in HepG2 cells and the rat liver. Therefore this study can lead to precise drug therapy of hyperlipidemia.

Research Products

• [Journal Article] receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver. Biochim. (2009)
  • Author(s): Chisaki, I., Kobayashi, M., Itagaki, S., Hirano, T. Iseki, K. Liver X
  • Journal Title: Biophys. Acta 1788(11) Pages: 2396-2403
  • Peer Reviewed
• [Journal Article] Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver (2009)
  • Author(s): Chisaki I, Kobayashi M, Itagaki S, Hirano T, Iseki K
  • Journal Title: Biochimica et Biophysica Acta 1788(11) Pages: 2396-2403
  • NAID: 120001702428
  • Peer Reviewed
• [Presentation] スタチン系薬物による肝ATP-binding cassette transporter A1 (ABCA1)発現に及ぼす影響 (2009)
  • Author(s): 合田圭佑, 小林正紀, 知嵜郁美, 板垣史郎, 井関健
  • Organizer: 第24回日本薬物動態学会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-28
• [Presentation] スタチン系薬物による肝ATP-binding cassette transporter A1(ABCA1)発現に及ぼす影響 (2009)
  • Author(s): 合田圭祐、小林正記、知嵜郁美、板垣史郎、井関健
  • Organizer: 日本薬物動態学会 第24回年会
  • Place of Presentation: 国立京都国際会館, 京都
  • Year and Date: 2009-11-28
• [Presentation] 肝MRP2発現に与えるスタチン系薬物の影響 (2008)
  • Author(s): 知嵜郁美、小林正紀、板垣史郎, 平野剛, 井関健
  • Organizer: 第23回日本薬物動態学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-30
• [Presentation] 肝MRP2発現に与えるスタチン系薬物の影響 (2008)
  • Author(s): 知嵜郁美、小林正紀、板垣史郎、平野剛、井関健
  • Organizer: 第23回日本薬物動態学会年会
  • Place of Presentation: 熊本交通センターホテル
  • Year and Date: 2008-10-30