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Developmental research for measurement of acrolein and polyamine oxidase as markers for diagnosis of brain infarction

Research Project

Project/Area Number 20790143
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionChiba Institute of Science

Principal Investigator

TOMITORI Hideyuki  Chiba Institute of Science, 薬学部, 講師 (30337381)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords生理活性物質 / 脳・神経 / バイオマーカー / 臨床化学 / 薬物治療・トキシコロジー / ポリアミン / アクロレイン / ポリアミンオキシダーゼ / 脳梗塞
Research Abstract

Polyamines play important roles in cell proliferation and differentiation. However, acrolein that is highly toxic compound is produced by polyamine oxidation. In this study, new methods for measuring acrolein and polyamine oxidases, and molecular mechanism of acrolein toxicity on cell growth have been studied. New findings in this study have been described below.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (13 results)

  • [Journal Article] Identification of acrolein-conjugated protein in plasma of patients with brain infarction. Biochem2010

    • Author(s)
      Yoshida, M., Higashi, K., Jin, L., Machi, Y., Suzuki, T., Masuda, A., Dohmae, N., Suganami, A., Tamura, Y., Nishimura, K., Toida, T., Tomitori, H., Kashiwagi, K., Igarashi, K.
    • Journal Title

      Biophys. Res. Commun. 391

      Pages: 1234-1239

    • Related Report
      2009 Final Research Report
  • [Journal Article] Identification of acrolein-conjugated protein in plasma of patients with brain infarction.2010

    • Author(s)
      Yoshida, M.
    • Journal Title

      Biochem.Biophys.Res.Commun. 391

      Pages: 1234-1239

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of the synthesis of RpoE and StpA by polyamines at the level of translation in Escherichia coli under heat shock conditions2009

    • Author(s)
      Terui, Y., Higashi, K., Tabei, Y., Tomitori, H., Yamamoto, K., Ishihama, A., Igarashi, K., Kashiwagi, K.
    • Journal Title

      J. Bacteriol 191

      Pages: 5348-5357

    • Related Report
      2009 Final Research Report
  • [Journal Article] Acrolein, IL-6 and CRP as markers of silent brain infarction2009

    • Author(s)
      Yoshida, M., Tomitori, H., Machi, Y., Katagiri, D., Ueda, S., Horiguchi, K., Kobayashi, E., Saeki, N., Nishimura, K., Ishii, I., Kashiwagi, K., Igarashi, K.
    • Journal Title

      Atherosclerosis 203

      Pages: 557-562

    • Related Report
      2009 Final Research Report
  • [Journal Article] Acrolein toxicity: Comparison with reactive oxygen species2009

    • Author(s)
      Yoshida, M., Tomitori, H., Machi, Y., Hagihara, M., Higashi, K., Goda, H., Ohya, T., Niitsu, M., Kashiwagi, K., Igarashi, K.
    • Journal Title

      Biochem. Biophys. Res. Commun. 378

      Pages: 313-318

    • Related Report
      2009 Final Research Report
  • [Journal Article] Acrolein, IL-6 and CRP as markers of silent brain infarction2009

    • Author(s)
      Yoshida, M.
    • Journal Title

      Atherosclerosis 203

      Pages: 557-562

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of the synthesis of RpoE and StpA by polyamines at the level of translation in Escherichia coli under heat shock conditions2009

    • Author(s)
      Terui, Y.
    • Journal Title

      J.Bacteriol. 191

      Pages: 5348-5357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acrolein toxicity : Comparison with reactive oxygen species2009

    • Author(s)
      Yoshida, M., et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 378

      Pages: 313-318

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor2008

    • Author(s)
      Han, X., Tomitori, H., Mizuno, S., Higashi, K., Full, C., Fukiwake, T., Terui, Y., Leewanich, P., Nishimura, K., Toida, T., Williams, K., Kashiwagi, K., Igarashi, K.
    • Journal Title

      J. Neurochem 107

      Pages: 1566-1577

    • Related Report
      2009 Final Research Report
  • [Journal Article] Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor2008

    • Author(s)
      Han, X., et.al.
    • Journal Title

      J. Neurochem. 107

      Pages: 1500-1577

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] アダマンタンダイマーの合成と細胞増殖への影響2010

    • Author(s)
      荒野直紀
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] アダマンタンダイマーの合成と細胞増殖への影響2010

    • Author(s)
      荒野直紀
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポリアミンにより合成促進されるribosome modulation factorの大腸菌生存率維持に果たす役割2010

    • Author(s)
      秋山真律子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] ポリアミンにより合成促進されるribosome modulation factorの大腸菌生存率維持に果たす役割2010

    • Author(s)
      秋山真律子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] アクロレイン耐性細胞の樹立とそのアクロレイン毒性除去機構2009

    • Author(s)
      中村瑞穂
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド、兵庫
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ポリアミン酸化により産生されるアクロレインの毒性:活性酸素種との比較2009

    • Author(s)
      富取秀行
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド、兵庫
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Isolation and characterization of an acrolein tolerant mutant of FM3A cells2009

    • Author(s)
      富取秀行
    • Organizer
      2009 GORDON RESEARCH CONFERENCE ON POLYAMINES
    • Place of Presentation
      Waterville Valley, New Hampshire, USA
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Polyamine effect on protein synthesis and its mechanism2009

    • Author(s)
      Kashiwagi, K., Terui, Y., Higashi, K., Okudaira, H., Ochiai, E., Tomitori, H., Nishimura, K., Yamamoto, K., Ishihama, A., Igarashi, K.
    • Organizer
      Gordon Research Conference on Polyamines
    • Place of Presentation
      Waterville Valley, NH, USA
    • Year and Date
      2009-06-22
    • Related Report
      2009 Final Research Report
  • [Presentation] スペルミン及びイフェンプロジルのNMDA受容体調節領域への結合能2009

    • Author(s)
      韓霞
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] アクロレイン耐性細胞の樹立とその性質の検討2009

    • Author(s)
      富取秀行
    • Organizer
      日本ポリアミン研究会 第23回研究発表会
    • Place of Presentation
      藍野大学、大阪
    • Year and Date
      2009-01-23
    • Related Report
      2009 Final Research Report
  • [Presentation] アクロレイン耐性細胞の樹立とその性質の検討2009

    • Author(s)
      富取秀行
    • Organizer
      日本ポリアミン研究会第23回研究発表会
    • Place of Presentation
      藍野大学
    • Year and Date
      2009-01-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] PREDICTION OF SILENT BRAIN INFARCTION BY ACROLEIN, POLYAMINE OXIDASE2008

    • Author(s)
      富取秀行
    • Organizer
      IL-6 AND CRP Polyamines: Forty years of Mammalian Ornithine Decarboxylase
    • Place of Presentation
      Kuopio, Finland
    • Year and Date
      2008-06-28
    • Related Report
      2009 Final Research Report
  • [Presentation] PREDICTION OF SILENT BRAIN INFARCTION BY ACROLEIN POLYAMINE OXIDASE, IL-6 AND CRP2008

    • Author(s)
      富取秀行
    • Organizer
      Polyamines : Forty years of Mammalian Ornithine Decarboxylase
    • Place of Presentation
      Kuopio, Finland
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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