Interaction of nucleoside transport and drug transport in placental trophoblast cells at various stages of pregnancy
| Project/Area Number |
20790144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
KOSE Noriko Keio University, 薬学部, 研究員 (60348612)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 血液胎盤関門 / 核酸輸送担体 / 薬物輸送担体 / adenosine / ddI / AZT / ENT / インテグレーションプロット / 妊娠糖尿 / CNT / 胎児発育不全 / uridine / TR-TBT / mannitol / イシテグレーションプロット / NBMPR / 薬学 / 医療・福祉 |
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| Research Abstract |
Standard methods of drug administration to pregnant woman have not been established. The purpose of this study was to clarify the interactions of nutrient and drug transport mechanisms in the placenta in order to establish safe, effective, and rational treatment methods for pregnant woman. We also aimed to clarify the transport mechanisms of drugs and nutrients in placenta under pathological conditions. As the supply of nucleosides is important for fetal growth, we focused on the interaction of transport mechanisms for drugs and nucleosides in the placenta. The uptake mechanisms of nucleosides in placenta in gestational diabetes was also clarified. These results should be useful for the establishment of standard methods of drug administration for the pregnant woman.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats.2010
Author(s)
Higuchi K, Iizasa H, Sai Y, Horieya S, Lee K-E, Wada M, Deguchi M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y-S, Nakashima E.
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Journal Title
Biol Pharm Bull
Volume: 33
Pages: 1400-1406
NAID
Related Report
Peer Reviewed
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[Journal Article] Proton-coupled erythromycin antiport at rat blood-placenta barrier.2010
Author(s)
Sai Y, Nishimura T, Ochi K, Tanaka N, Takagi A, Tomi M, Kose N, Kobayashi Y, Miyakoshi N, Kitagaki S, Mukai C, Nakashima E.
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Journal Title
Drug Metab Dispos
Volume: 38
Pages: 1576-1581
Related Report
Peer Reviewed
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