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Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts

Research Project

Project/Area Number 20790149
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionHokuriku University

Principal Investigator

TAKEDA Shuso  Hokuriku University, 薬学部, 講師 (00460379)

Research Collaborator 渡辺 和人  北陸大学, 薬学部, 教授 (30113038)
山本 郁男  九州保健福祉大学, 薬学部, 教授 (50069746)
山折 大  北陸大学, 薬学部, 助教 (40360218)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大麻草 / カンナビノイド / 乳がん / テトラヒドロカンナビノール / 大麻
Research Abstract

In the United States, THC has been used as medicine for patients suffering from heavy pan. We investigated whether or not THC, having a structure resembling estrogen, can affect estrogen-induced breast cancer progression. Although the action of estrogen was interfered with THC, in the low estrogen condition, breast cancer cell growth was stimulated by THC. Thus, it is suggested that there is an interaction between THC and estrogen, and that the action of THC might be influenced by the estrogen contents in the breast tissues.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (9 results)

  • [Journal Article] Cannabidiol-2', 6'-Dimethylether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor2009

    • Author(s)
      Takeda, S., Usami, N., Yamamoto, I., Watanabe, K.
    • Journal Title

      Drug Metab. Dispos. 37

      Pages: 1733-1737

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aromatase in MCF-7 Breast Cancer Cell Growth Induced byΔ9-Tetrahydrocannabinol2009

    • Author(s)
      Takeda, S., Yamamoto, I., Watanabe, K.
    • Journal Title

      Toxicology 259

      Pages: 25-32

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of Δ^9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxyeenase and aromatase2009

    • Author(s)
      Shuso Takeda
    • Journal Title

      Toxicology 259

      Pages: 25-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cannabidiol-2', 6'-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor2009

    • Author(s)
      Shuso Takeda
    • Journal Title

      Drug Metabolism and Disposition 37

      Pages: 1733-1737

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis2008

    • Author(s)
      Takeda, S., Misawa, K., Yamamoto, I., Watanabe, K.
    • Journal Title

      Drug Metab. Dispos. 36

      Pages: 1917-1921

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling2008

    • Author(s)
      Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K.
    • Journal Title

      Toxicology 245

      Pages: 141-146

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大麻文化科学考(その19)2008

    • Author(s)
      渡辺和人, 木村敏行, 山折大, 竹田修三, 宇佐見則行, 山本郁男
    • Journal Title

      紀要(北陸大学) 32

      Pages: 1-11

    • NAID

      120005469103

    • Related Report
      2009 Final Research Report
  • [Journal Article] Δ^9 -Tetrahydrocannabinol enhances MCF-7 cell proliferation viacannabinoid receptorindependent signaling2008

    • Author(s)
      Shuso Takeda
    • Journal Title

      Toxicology 245

      Pages: 141-146

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis2008

    • Author(s)
      Shuso Takeda
    • Journal Title

      Drug Metabolism and Disposition 36

      Pages: 1917-1921

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cannabidiol-2', 6'-dimethylether, a potent and selective inhibitor for low-density lipoprotein-producing enzyme2009

    • Author(s)
      竹田修三
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 大麻非幻覚成分カンナビジオールによるCYP1A発現誘導2009

    • Author(s)
      衣笠裕香
    • Organizer
      日本薬学会衛生部会:フォーラム2009:衛生薬学・環境トキシコロジー
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 動脈硬化症予防を目指した新規バイオプローブの開発:悪玉コレステロール生成酵素阻害に基づくアプローチ2009

    • Author(s)
      竹田修三
    • Organizer
      第8回次世代を担う若手ファーマ・バイオフォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] カンナビジオール誘導体、カンナビジオール-2', 6'-ジメチルエーテル:選択的かつ強力な15-リポキシゲナーゼ阻害剤2009

    • Author(s)
      竹田修三
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Δ9-テトラヒドロカンナビノールによるMCF-7乳がん細胞増殖の細胞内エストロジェン産生系による調節2008

    • Author(s)
      竹田修三
    • Organizer
      日本薬学会衛生部会:フォーラム2008:衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Δ^9- テトラヒドロカンナビノールによるMCF-7乳がん細胞増殖の細胞内エストロジェン産生系による調節2008

    • Author(s)
      竹田修三
    • Organizer
      日本薬学会衛生部会 : フォーラム2008 : 衛生薬学・環境トキシコロジー
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] カンナビジオール酸, 大麻草中の選択的シクロオキシゲナーゼ-2活性阻害成分2008

    • Author(s)
      竹田修三
    • Organizer
      日本法中毒学会第27年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2009 Final Research Report
  • [Presentation] カンナビジオール酸, 大麻草中の選択的シクロオキシゲナーゼー2活性阻害成分2008

    • Author(s)
      竹田修三
    • Organizer
      日本法中毒学会第27年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット精巣3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4 isomeraseに対するカンナビノイドの阻害作用2008

    • Author(s)
      三澤宏一郎
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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