Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts

• Project/Area Number: 20790149
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Hokuriku University
• Principal Investigator: TAKEDA Shuso Hokuriku University, 薬学部, 講師 (00460379)
• Research Collaborator: 渡辺 和人 北陸大学, 薬学部, 教授 (30113038) ; 山本 郁男 九州保健福祉大学, 薬学部, 教授 (50069746) ; 山折 大 北陸大学, 薬学部, 助教 (40360218)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大麻草 / カンナビノイド / 乳がん / テトラヒドロカンナビノール / 大麻

Research Abstract

In the United States, THC has been used as medicine for patients suffering from heavy pan. We investigated whether or not THC, having a structure resembling estrogen, can affect estrogen-induced breast cancer progression. Although the action of estrogen was interfered with THC, in the low estrogen condition, breast cancer cell growth was stimulated by THC. Thus, it is suggested that there is an interaction between THC and estrogen, and that the action of THC might be influenced by the estrogen contents in the breast tissues.

Research Products

• [Journal Article] Cannabidiol-2', 6'-Dimethylether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor (2009)
  • Author(s): Takeda, S., Usami, N., Yamamoto, I., Watanabe, K.
  • Journal Title: Drug Metab. Dispos. 37 Pages: 1733-1737
  • Peer Reviewed
• [Journal Article] Aromatase in MCF-7 Breast Cancer Cell Growth Induced byΔ9-Tetrahydrocannabinol (2009)
  • Author(s): Takeda, S., Yamamoto, I., Watanabe, K.
  • Journal Title: Toxicology 259 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Modulation of Δ^9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxyeenase and aromatase (2009)
  • Author(s): Shuso Takeda
  • Journal Title: Toxicology 259 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Cannabidiol-2', 6'-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor (2009)
  • Author(s): Shuso Takeda
  • Journal Title: Drug Metabolism and Disposition 37 Pages: 1733-1737
  • Peer Reviewed
• [Journal Article] Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis (2008)
  • Author(s): Takeda, S., Misawa, K., Yamamoto, I., Watanabe, K.
  • Journal Title: Drug Metab. Dispos. 36 Pages: 1917-1921
  • Peer Reviewed
• [Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling (2008)
  • Author(s): Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K.
  • Journal Title: Toxicology 245 Pages: 141-146
  • Peer Reviewed
• [Journal Article] 大麻文化科学考(その19) (2008)
  • Author(s): 渡辺和人, 木村敏行, 山折大, 竹田修三, 宇佐見則行, 山本郁男
  • Journal Title: 紀要(北陸大学) 32 Pages: 1-11
  • NAID: 120005469103
• [Journal Article] Δ^9 -Tetrahydrocannabinol enhances MCF-7 cell proliferation viacannabinoid receptorindependent signaling (2008)
  • Author(s): Shuso Takeda
  • Journal Title: Toxicology 245 Pages: 141-146
  • Peer Reviewed
• [Journal Article] Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis (2008)
  • Author(s): Shuso Takeda
  • Journal Title: Drug Metabolism and Disposition 36 Pages: 1917-1921
  • Peer Reviewed
• [Presentation] Cannabidiol-2', 6'-dimethylether, a potent and selective inhibitor for low-density lipoprotein-producing enzyme (2009)
  • Author(s): 竹田修三
  • Organizer: 第3回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2009-11-15
• [Presentation] 大麻非幻覚成分カンナビジオールによるCYP1A発現誘導 (2009)
  • Author(s): 衣笠裕香
  • Organizer: 日本薬学会衛生部会:フォーラム2009:衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-15
• [Presentation] 動脈硬化症予防を目指した新規バイオプローブの開発:悪玉コレステロール生成酵素阻害に基づくアプローチ (2009)
  • Author(s): 竹田修三
  • Organizer: 第8回次世代を担う若手ファーマ・バイオフォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-14
• [Presentation] カンナビジオール誘導体、カンナビジオール-2', 6'-ジメチルエーテル:選択的かつ強力な15-リポキシゲナーゼ阻害剤 (2009)
  • Author(s): 竹田修三
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] Δ9-テトラヒドロカンナビノールによるMCF-7乳がん細胞増殖の細胞内エストロジェン産生系による調節 (2008)
  • Author(s): 竹田修三
  • Organizer: 日本薬学会衛生部会:フォーラム2008:衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-17
• [Presentation] Δ^9- テトラヒドロカンナビノールによるMCF-7乳がん細胞増殖の細胞内エストロジェン産生系による調節 (2008)
  • Author(s): 竹田修三
  • Organizer: 日本薬学会衛生部会 : フォーラム2008 : 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-17
• [Presentation] カンナビジオール酸, 大麻草中の選択的シクロオキシゲナーゼ-2活性阻害成分 (2008)
  • Author(s): 竹田修三
  • Organizer: 日本法中毒学会第27年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-14
• [Presentation] カンナビジオール酸, 大麻草中の選択的シクロオキシゲナーゼー2活性阻害成分 (2008)
  • Author(s): 竹田修三
  • Organizer: 日本法中毒学会第27年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-14
• [Presentation] ラット精巣3β-hydroxysteroid dehydrogenase/Δ^5-Δ^4 isomeraseに対するカンナビノイドの阻害作用 (2008)
  • Author(s): 三澤宏一郎
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27