| Project/Area Number |
20790184
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
|
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
NAKAJO Koichi National Institute for Physiological Sciences, 分子生理研究系, 助教 (80390699)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | イオンチャネル / カリウムチャネル / 生物物理学 / 生理学 / 電位センサー / 電気生理学 / 分子生物学 / ホヤ / 不整脈 / 心筋 |
|---|
| Research Abstract |
KCNQ1, a voltage-gated potassium channel main subunit, is expressed in various tissues like heart, inner ear and intestine, and also known as a causative gene for cardiac arrhythmia and deafness. The property of this ion channel is largely dependent on its auxiliary subunit, KCNE proteins. In this study, we identified some important amino acid residues for KCNQ1 channel modulation by KCNE proteins by comparing human KCNQ1 gene to KCNQ1 homologue from ascidian Ciona intestinalis
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