Physiological analysis of novel orphan GPCR involved in energy homeostasis
| Project/Area Number |
20790187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SANO Takamitsu The Institute of Physical and Chemical Research, 神経膜機能研究チーム, 客員研究員 (10399967)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | GPCR / エネルギーホメオスタシス / 肥満 |
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| Research Abstract |
Drosophila orphan GPCR, bride of sevenless (BOSS) responds to extracellular glucose and regulates sugar and lipid metabolism. BOSS is evolutionally conserved from fly to human. In mammal, four homologues of BOSS, GPRC5A, GPRC5B, GPRC5C, and GPRC5D, exist. However, their molecular and physiological functions remain unclear. Here, we describe the role of GPRC5B in the regulation of energy homeostasis. GPRC5B was expressed highly in the brain and adipose tissue. GPCR5B-deficient mice showed decreased weight gain compared with wild type mice, despite of the similar food intake. This phenotype was attributed to increased oxygen consumption, but not increased physical activity.
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Report
(3 results)
Research Products
(5 results)
