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Joint disease and clock genes

Research Project

Project/Area Number 20790250
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKanazawa University

Principal Investigator

TAKARADA Takeshi  Kanazawa University, 薬学系, 助教 (30377428)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords時計遺伝子 / 軟骨細胞 / 骨関節組織 / indian hedgehog / Indian hedgehog / Bmall / Bmal1 / Per1
Research Abstract

We have investigated the possible role of clock genes in mechanism underlying the regulation of chondrogenic differentiation processes. The results suggested that chondrogenic differentiation may be modulated by clock genes expressed by chondrocytes in association with the inhibition by Per1 of Bmal1/Clock-dependent indian hedgehog expression.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (83 results)

All 2010 2009 2008 Other

All Journal Article (29 results) (of which Peer Reviewed: 26 results) Presentation (52 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Induced tolerance to glutamate neurotoxicity through downregulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons.2010

    • Author(s)
      Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori, Yukio Yoneda
    • Journal Title

      J. Neurosci. Res. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca2+ influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly.2010

    • Author(s)
      Noritaka Nakamichi*, Ryo Fukumori*, Takeshi Takarada, Yuki Kambe, Tomomi, Yamamoto, Nobuyuki Matsushima, Nobuaki Moriguchi, Yukio Yoneda
    • Journal Title

      J. Neurosci. Res. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate receptor channels.2010

    • Author(s)
      Ryo Fukumori*, Noritaka Nakamichi*, Takeshi Takarada, Yuki Kambe, Nobuyuki Matsushima, Nobuaki Moriguchi, Yukio Yoneda
    • Journal Title

      J. Pharmacol. Sci. 112

      Pages: 273-281

    • NAID

      10027744270

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca^<2+> influx through acquired and native N-methyl-D-aspartate receptor channels.2010

    • Author(s)
      Ryo Fukumori*, Noritaka Nakamichi*, Takeshi Takarada, Yuki Kambe, Nobuyuki Matsushima, Nobuaki Moriguchi, Yukio Yoneda
    • Journal Title

      J.Pharmacol.Sci. (掲載確定)

    • NAID

      10027744270

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca^<2+> influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly.2010

    • Author(s)
      Noritaka Nakamichi, Ryo Fukumori, Takeshi Takarada, Yuki Kambe, Tomomi, Yamamoto, Nobuyuki Matsushima, Nobuaki Moriguchi, Yukio Yoneda
    • Journal Title

      J.Neurosci.Res. (掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced tolerance to glutamate neurotoxicity through downregulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons.2010

    • Author(s)
      Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori, Yukio Yoneda
    • Journal Title

      J.Neurosci.Res. (掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.2009

    • Author(s)
      Takeshi Takarada*, Keisuke Tamaki*, Toru Takumi, Masato Ogura, Yuma Ito, Noritaka Nakamichi, Yukio Yoneda
    • Journal Title

      J Neurochem 110

      Pages: 1457-1468

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members.2009

    • Author(s)
      Takeshi Takarada, Hironori Hojo, Mika Iemata, Koichi Sahara, Ayumi Kodama, Nobuhiro Nakamura, Eiichi Hinoi, Yukio Yoneda
    • Journal Title

      Bone 45

      Pages: 568-578

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.2009

    • Author(s)
      Takeshi Takarada, Yoshifumi Takahata, Mika Iemata, Eiichi Hinoi, Kyosuke Uno, Takao Hirai, Tomomi Yamamoto, Yukio Yoneda
    • Journal Title

      J Cell Physiol 220

      Pages: 756-764

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism.2009

    • Author(s)
      Noritaka Nakamichi, Yukichi Ishioka, Takao Hirai, Shusuke Ozawa, Masaki Tachibana, Nobuhiro Nakamura, Takeshi Takarada, Yukio Yoneda
    • Journal Title

      J Neurosci Res 87

      Pages: 2406-2417

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.2009

    • Author(s)
      Yukari Nakamura*, Takeshi Takarada*, Ayumi Kodama, Eiichi Hinoi, Yukio Yoneda
    • Journal Title

      J Pharmacol Sci 109

      Pages: 413-423

    • NAID

      10025735254

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transactivation by runt related factor-2 of matrix metalloproteinase-13 in astrocytes.2009

    • Author(s)
      Takeshi Takarada, Yukio Yoneda
    • Journal Title

      Neurosci Lett 451

      Pages: 99-104

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly.2009

    • Author(s)
      Bin Gu*, Noritaka Nakamichi*, Wen-Sheng Zhang, Yukary Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takeshi Takarada, Hideo Taniura, Yukio Yoneda
    • Journal Title

      J Neurosci Res 87

      Pages: 2145-2156

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes.2009

    • Author(s)
      Yukari Nakamura, Takeshi Takarada, Ayumi Kodama, Eiichi Hinoi, Yukio Yoneda
    • Journal Title

      J Pharwacol Sci 109

      Pages: 413-423

    • NAID

      10025735254

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.2009

    • Author(s)
      Takeshi Takarada, Keisuke Tamaki, Toru Takumi, Masato Ogura, Yuma Ito, Noritaka Nakamichi, Yukio Yoneda
    • Journal Title

      J Neurochem 110

      Pages: 1457-1468

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 代謝調節型グルタミン酸受容体のサブタイプ2009

    • Author(s)
      宝田剛志, 米田幸雄
    • Journal Title

      生体の科学 60

      Pages: 358-359

    • Related Report
      2009 Annual Research Report
  • [Journal Article] NMDA受容体のポリアミン部位と神経突起の伸長.2009

    • Author(s)
      宝田剛志, 米田幸雄
    • Journal Title

      生体の科学 60

      Pages: 368-369

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 未分化神経細胞における繊毛性神経栄養因子(CNTF)受容体のGABA_A受容体による発現増.2009

    • Author(s)
      宝田剛志, 米田幸雄
    • Journal Title

      生体の科学 60

      Pages: 384-385

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly2009

    • Author(s)
      Bin Gu, Noritaka Nakamichi, Wen-Sheng Zhang, Yukary Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takeshi Takarada, Hideo Taniura and Yukio Yoneda
    • Journal Title

      J Neurosci Res (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transactivation by runt related factor-2 of matrix metalloproteinase-13 in astrocytes2009

    • Author(s)
      Takeshi Takarada and Yukio Yoneda
    • Journal Title

      Neurosci Lett 451

      Pages: 99-104

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes2009

    • Author(s)
      Yukari Nakamura, Takeshi Takarada, Ayumi Kodama, Eiichi Hinoi and Yukio Yoneda
    • Journal Title

      J Pharmacol Sci in press (掲載確定)

    • NAID

      10025735254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism2009

    • Author(s)
      Noritaka Nakamichi, Yukichi Ishioka, Takao Hirai, Shusuke Ozawa, Masaki Tachibana, Nobuhiro Nakamura, Takeshi Takarada and Yukio Yoneda
    • Journal Title

      J Neurosci Res (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurogenesis mediated by GABA and glutamate signaling2009

    • Author(s)
      Noritaka Nakamichi, Takeshi Takarada and Yukio Yoneda
    • Journal Title

      J Pharmacol Sci (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells.2008

    • Author(s)
      Yoshifumi Takahata*, Takeshi Takarada*, Mika Iemata, Tomomi Yamamoto, Yukary Nakamura, Ayumi Kodama, Yukio Yoneda
    • Journal Title

      J Cell Physiol 218

      Pages: 268-275

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation2008

    • Author(s)
      Danko D. Georgiev, Hideo Taniura, Yuki Kambe, Takeshi Takarada, Yukio Yoneda
    • Journal Title

      Exp Cell Res 314

      Pages: 2603-2617

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine.2008

    • Author(s)
      Yoshifumi Takahata, Takeshi Takarada*, Masato Osawa, Eiichi Hinoi, Yukari Nakamura, Yukio Yoneda
    • Journal Title

      Cell Tissue Res 333

      Pages: 91-103

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine2008

    • Author(s)
      Yoshifumi Takahata, Takeshi Takarad a, Masato Osawa, Eiichi Hinoi, Yukari Nakamura & Yukio Yoneda
    • Journal Title

      Cell Tissue Res 333

      Pages: 91-103

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation2008

    • Author(s)
      Danko D. Georgiev, Hideo Taniura, Yuki Kambe, Takeshi Takarada & Yukio Yoneda
    • Journal Title

      Exp Cell Res 314

      Pages: 2603-2617

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional expression of beta2 adrenergic receptors responsiblefor protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells2008

    • Author(s)
      Yoshifumi Takahata, Takeshi Takarada, Mika lemata, Tomomi Yamamoto, Yukary Nakamura, Ayumi Kodama and Yukio Yoneda
    • Journal Title

      J Cell Physiol 218

      Pages: 268-275

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経幹細胞とPTSD分子病態2010

    • Author(s)
      宝田剛志, 伊藤佑真, 米田幸雄
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-06-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳虚血応答性遺伝子Ifrd1の機能解析2010

    • Author(s)
      宝田剛志, 小西志歩, 米田幸雄
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      就実大学(岡山)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] アストロサイトに発現するRunx2の機能解析2010

    • Author(s)
      宝田剛志、米田幸雄
    • Organizer
      第24回放射性同位元素研究連絡会
    • Place of Presentation
      金沢大学(石川)
    • Year and Date
      2010-03-10
    • Related Report
      2009 Final Research Report
  • [Presentation] アストロサイトに発現するRunx2の機能解析2010

    • Author(s)
      宝田剛志、米田幸雄
    • Organizer
      第24回放射性同位元素研究連絡会
    • Place of Presentation
      金沢大学(石川県)
    • Year and Date
      2010-03-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経幹細胞とPTSD分子病態2010

    • Author(s)
      宝田剛志, 伊藤佑真, 米田幸雄
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳虚血応答性遺伝子Ifrd1の機能解析2010

    • Author(s)
      宝田剛志, 小西志歩, 米田幸雄
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      就実大学(岡山県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 時計遺伝子による軟骨細胞成熟過程の制御2009

    • Author(s)
      児玉歩美, 宝田剛志, 檜井栄一, 米田 幸雄
    • Organizer
      第116回日本薬理学会近畿部会
    • Place of Presentation
      ピアザ淡海(滋賀)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Expressiom of Runt Related Factor-2 by Astrocytes2009

    • Author(s)
      Takeshi Takarada, Mika Takarada, Masaki Tachibana, Yukio Yoneda
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Final Research Report
  • [Presentation] Bone-related genes expressed in brain.2009

    • Author(s)
      Takeshi Takarada, Yukio Yoneda
    • Organizer
      The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
    • Place of Presentation
      BEXCO(Korea)
    • Related Report
      2009 Final Research Report
  • [Presentation] アストロサイトにおけるRunt related factor-2の機能的発現2009

    • Author(s)
      宝田剛志, 家亦美佳, 橘正毅, 米田幸雄
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保温泉ホテル天坊(群馬)
    • Related Report
      2009 Final Research Report
  • [Presentation] Clock Genes Expressed by Microglial Cells.2009

    • Author(s)
      Tomomi Yamamoto, Takeshi Takarada, Ayumi Kodama, Masaki Tachibana, Yukio Yoneda
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Final Research Report
  • [Presentation] Clock genes expressed in cultured microglia.2009

    • Author(s)
      Yamamoto, T., Takarada, T., Kodama, A., Tachibana, M., Yoneda, Y.
    • Organizer
      The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
    • Place of Presentation
      BEXCO(Korea)
    • Related Report
      2009 Final Research Report
  • [Presentation] ミクログリア細胞における時計遺伝子の機能的発現2009

    • Author(s)
      山本朋未, 宝田剛志, 米田幸雄
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保温泉ホテル天坊(群馬)
    • Related Report
      2009 Final Research Report
  • [Presentation] 時計遺伝子Per1による軟骨細胞成熟調節2009

    • Author(s)
      テル天坊(群馬) [11]児玉歩美, 宝田剛志, 佐原甲一, 檜井 栄一, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2009 Final Research Report
  • [Presentation] アストロサイトにおけるRunt related factor-2の機能的発現2009

    • Author(s)
      宝田剛志, 家亦美佳, 橘正毅, 米田幸雄
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保温泉(群馬県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone-related genes expressed in brain.2009

    • Author(s)
      Takarada, T., Yoneda, Y.
    • Organizer
      The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
    • Place of Presentation
      BEXCO (Busan, Korea)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Expression of Runt Related Factor-2 by Astrocytes.2009

    • Author(s)
      Takeshi Takarada, Mika Takarada, Masaki Tachibana, Yukio Yoneda
    • Organizer
      第19回 日本臨床精神神経薬理学会・第39回 日本神経精神薬理学会 合同年会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内グルタチオン濃度制御を介するグルタミン酸による間葉系幹細胞の分化調整2009

    • Author(s)
      家亦美佳, 宝田剛志, 米田幸雄
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] シスチン/グルタミン酸アンチポーター安定発現骨芽細胞株の樹立2009

    • Author(s)
      宇野恭介, 宝田剛志, 浜道啓太, 米田幸雄
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] GABARによる骨芽細胞の成熟調節2009

    • Author(s)
      高畑佳史, 宝田剛志, 宇野恭介, 藤森さゆ美, 檜井栄一, 米田幸雄
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Runt related factor-2のアストロサイトにおける機能的発現2009

    • Author(s)
      宝田剛志, 米田幸雄
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Runt related factor-2発現の脳内局在性2009

    • Author(s)
      橘正毅, 宝田剛志, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス中大脳動脈結紮モデルの作製2009

    • Author(s)
      小西志歩, 宝田剛志, 中道範隆, 黒川晋太郎, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪細胞に発現するGABAシグナル分子2009

    • Author(s)
      中村由香里, 宝田剛志, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] HEK293細胞における機能的NMDA受容体の強制発現2009

    • Author(s)
      福森良, 谷浦秀夫, 中道範隆, 宝田剛志, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 時計遺伝子Per1による軟骨細胞成熟調節2009

    • Author(s)
      児玉歩美, 宝田剛志, 佐原甲一, 檜井栄一, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨細胞株MLO-Y4細胞の機能解析2009

    • Author(s)
      中谷絵莉, 家亦美佳, 中島紘子, 宝田剛志, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Runx2プロモーターを安定発現する骨芽細胞株MC3T3-E1細胞の樹立2009

    • Author(s)
      浜道啓太, 宇野恭介, 檜井栄一, 宝田剛志, 米田幸雄
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] GABABR1サブユニット安定発現骨芽細胞株の機能解析2008

    • Author(s)
      高畑佳史, 宝田剛志, 宇野恭介, 藤森さゆ美, 檜井栄一, 米田幸雄
    • Organizer
      第114回日本薬理学会近畿部会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳内における骨関節系遺伝子の発現2008

    • Author(s)
      宝田剛志, 米田幸雄
    • Organizer
      第114回日本薬理学会近畿部会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 時計遺伝子による軟骨細胞株ATDC5細胞の分化制御2008

    • Author(s)
      佐原甲一, 宝田剛志, 檜井栄一, 米田 幸雄
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      ホテルグランヴィア岡山(岡山)
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report
  • [Presentation] ミクログリア細胞における時計遺伝子の発現2008

    • Author(s)
      テルグランヴィア岡山(岡山) [17]山本朋未, 宝田剛志, 佐原甲一, 小椋 正人, 谷浦秀夫, 米田幸雄
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      ホテルグランヴィア岡山(岡山)
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report
  • [Presentation] ミクログリア細胞における時計遺伝子の発現2008

    • Author(s)
      山本朋未, 宝田剛志, 佐原甲一, 小椋正人, 谷浦秀夫, 米田幸雄
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 時計遺伝子による軟骨細胞株ATDC5細胞の分化制御2008

    • Author(s)
      佐原甲一, 宝田剛志, 檜井栄一, 米田幸雄
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 間葉系幹細胞に発現するアドレナリン受容体の機能2008

    • Author(s)
      高畑佳史, 家亦美佳, 宝田剛志, 米田幸雄
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨細胞に発現するIndian hedgehogの時計遺伝子による調節機構2008

    • Author(s)
      宝田剛志, 佐原甲一, 米田幸雄
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2009 Final Research Report
  • [Presentation] ミクログリア細胞に発現する時計遺伝子2008

    • Author(s)
      山本朋未, 宝田剛志, 佐原甲一, 小椋 正人, 谷浦秀夫, 米田幸雄
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      品川プリンスホテル(東京)
    • Related Report
      2009 Final Research Report
  • [Presentation] ミクログリア細胞に発現する時計遺伝子群2008

    • Author(s)
      山本朋未, 宝田剛志, 佐原甲一, 橘正毅, 谷浦秀夫, 米田幸雄
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      第51回日本神経化学会大会(富山)
    • Related Report
      2009 Final Research Report
  • [Presentation] 軟骨細胞分化における時計遺伝子Period1の役割2008

    • Author(s)
      児玉歩美, 佐原甲一, 宝田剛志, 米田 幸雄
    • Organizer
      生体機能と創薬シンポジウム
    • Place of Presentation
      星薬科大学(東京)
    • Related Report
      2009 Final Research Report
  • [Presentation] グルタミン酸神経毒性に対する田七人参含有成分notoginsenosideR1の保護効果2008

    • Author(s)
      顧彬, 中村有加里, 神戸悠輝, 田熊一散, 山田清文, 張文生, 宝田剛志, 中道範隆, 米田幸雄
    • Organizer
      生体機能と創薬シンポジウム2008
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨細胞分化における時計遺伝子Period1の役割2008

    • Author(s)
      児玉歩美, 佐原甲一, 宝田剛志, 米田幸雄
    • Organizer
      生体機能と創薬シンポジウム2008
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] GABAシグナルによる神経系前駆細胞の増殖と分化の調節2008

    • Author(s)
      小澤秀介, 福井正樹, 宝田剛志, 谷浦秀夫, 中道範隆, 米田幸雄
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] ミクログリア細胞に発現する時計遺伝子群2008

    • Author(s)
      山本朋未, 宝田剛志, 佐原甲一, 橘正毅, 谷浦秀夫, 米田幸雄
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨関連遺伝子の脳内における発現2008

    • Author(s)
      宝田剛志, 黒川晋太郎, 砺波, 佑介, 小西志歩, 米田幸雄
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中大脳動脈決紮に伴う脳内グルタメイトレセプターの発現変化2008

    • Author(s)
      黒川晋太郎, 原智也, 小西志歩, 宝田剛志, 中道範隆, 米田幸雄
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス脳海馬におけるPTSD応答性ミオシンVIの発現2008

    • Author(s)
      橘正毅, 玉置啓祐, 伊東佑真, 宝田剛志, 谷浦秀夫, 中道範隆, 米田幸雄
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳における骨関節系遺伝子の発現2008

    • Author(s)
      小西志歩, 宝田剛志, 黒川晋太郎, 米田幸雄
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ミクログリア細胞に発現する時計遺伝子2008

    • Author(s)
      山本朋未, 宝田剛志, 佐原甲一, 小椋正人, 谷浦秀夫, 米田幸雄
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] シスチン/グルタミン酸アンチポーターによる骨芽細胞の増殖制御2008

    • Author(s)
      宇野恭介, 宝田剛志, 浜道啓太, 米田幸雄
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] グルタミン酸による細胞内グルタチオン濃度調節を介する骨芽細胞分化抑制2008

    • Author(s)
      家亦美佳, 宝田剛志, 米田幸雄
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 軟骨細胞に発現するIndian hedgehogの時計遺伝子による調節機構2008

    • Author(s)
      宝田剛志, 佐原甲一, 米田幸雄
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 間葉系幹細胞に発現するアドレナリン受容体の機能2008

    • Author(s)
      高畑佳史, 宝田剛志, 家亦美佳, 山本朋未, 宇野恭介, 米田幸雄
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Book] 臨床精神薬理ハンドブック(監修;樋口輝彦、小山司)2009

    • Author(s)
      米田幸雄, 宝田剛志
    • Total Pages
      6
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~yakubutu/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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