Analysis of host cell cycle arrest mechanism by EPEC infection

• Project/Area Number: 20790330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bacteriology (including Mycology)
• Research Institution: The University of Tokyo
• Principal Investigator: KIM Minsoo The University of Tokyo, 医科学研究所, 特任助教 (50466835)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 感染免疫 / 細胞周期 / 病原性大腸菌

Research Abstract

EPEC infection causes host cell cycle arrest. We found that Cif (cell cycle inhibiting factors) secreted by EPEC on bacterial infection inhibited host cell cycle progression at G1 Phase by interacting with host cell factor. Our study suggested that EPEC deploys a special tactic to prevent rapid epithelial turnover in order to maintain epithelial cells.

Research Products

• [Journal Article] Bacterial hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment (2009)
  • Author(s): Kim M, Ogawa M, Fujita Y, Yoshikawa Y, Nagai T, Koyama T, Nagai S, Lange A, Fassler R, Sasakawa C
  • Journal Title: Nature 459 Pages: 578-582
  • Peer Reviewed
• [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition (2009)
  • Author(s): Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim Minsoo, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C
  • Journal Title: Nature Cell biology 11(19) Pages: 1233-1240
  • Peer Reviewed
• [Journal Article] Bacterial hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment (2009)
  • Author(s): Kim, et al.
  • Journal Title: Nature 459 Pages: 578-582
  • Peer Reviewed
• [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition (2009)
  • Author(s): Yoshikawa, et al.
  • Journal Title: Nature Cell Biology 11 Pages: 1233-1240
  • Peer Reviewed
• [Journal Article] A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation (2008)
  • Author(s): Kim M, Nakamoto T, Nishimori S, Tanaka K, Chiba T
  • Journal Title: EMBO reports 9 Pages: 878-884
• [Journal Article] A new ubiquitin ligase involved in p57^<KIP2> proteolysis regulates osteoblast cell differentiation (2008)
  • Author(s): Minsoo Kim et.al.
  • Journal Title: EMBO reports 9 Pages: 878-884
  • Peer Reviewed
• [Presentation] 細菌エフェクターOspEとインテグリンリンクドキナーゼの結合による感染細胞の剥離抑制機構 (2009)
  • Author(s): 金 〓秀
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] 赤痢菌のエフェクターによる腸管上皮細胞のターンオーバー抑制 (2008)
  • Author(s): 金 〓秀
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Book] Cbl proteins (2008)
  • Author(s): Tezuka T, Kim M, Yamamoto T
  • Publisher: NOVA publishers
• [Book] Cbl proteins (2008)
  • Author(s): Tezuka Tohru et.al.
  • Publisher: NOVA publishers
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_16.php
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_18.php
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_16.php
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_18.php