The effects of nanoparticle-rich diesel exhaust on hepatic PPARα
Project/Area Number |
20790423
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Hygiene
|
Research Institution | Nagoya University |
Principal Investigator |
ITO YUKI Nagoya University, 大学院・医学研究科, 助教 (80452192)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | ディーゼル排気ナノ粒子 / ペルオキシゾーム活性化受容体 / 脂質代謝 / 炎症 / 肝臓 / 大気汚染 / 遺伝子改変動物 / ペルオキシゾーム増殖剤活性化受容体 / サイトカイン |
Research Abstract |
Diesel exhaust is a main airborne contaminant and includes many nanoparticles. The effects of nanoparticle-rich diesel exhaust (NR-DE) on liver in male rats were investigated in this study. Exposure conditions were chosen according to environmental fate of diesel exhaust. NR-DE at the concentrations near the value of environmental standard for 1 month induced hepatic inflammation which did not persist. It was suggested that the nuclear receptor in the liver played a role in this inflammation.
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Report
(4 results)
Research Products
(11 results)