The effect of DGAT on liver steatosis, fibrosis and carcinogenesis in murine NASH models.

• Project/Area Number: 20790503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YAMAGUCHI Kanji Kyoto Prefectural University of Medicine, 医学研究科, 助教(寄附講座) (50381950)
• Research Collaborator: ITOH Yoshito 京都府立医科大学, 医学研究科, 准教授 (70244613)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: DGAT / 炎症 / 肝脂肪化 / 肝線維化 / 肝発癌

Research Abstract

Suppression of DGAT2, which is highly expressed in hepatocytes, ameliorated liver steatosis but worsened liver fibrosis. This observation suggests that triglyceride synthesis helps to protect the liver from lipotoxicity by buffering FFA accumulation.

Research Products

• [Journal Article] Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. (2010)
  • Author(s): Yamaguchi K, Itoh Y, Yokomizo C, Nishimura T, Niimi T, Fujii H, Okanoue T, Yoshikawa T.
  • Journal Title: Lab Invest. 90(8) Pages: 1169-1178
• [Journal Article] Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. (2010)
  • Author(s): Yamaguchi Kanji, et al.
  • Journal Title: Laboratory investigation Volume: Aug;90(8) Pages: 1169-78
  • Peer Reviewed
• [Presentation] マウス脂肪肝、脂肪性肝炎モデルにおけるIL-6と肝脂肪化の関係について (2009)
  • Author(s): 山口寛二、伊藤義人、横溝千尋、西村健、新美敏久、岡上武、吉川敏一
  • Organizer: 第38回日本肝臓学会西部会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-12-04
• [Presentation] Blockade of Interleukin 6 Trans-Signaling Enhanced Hepatic Steatosis but Improved Liver Injury in Methionine Choline Deficiency Diet-Fed Mice (2009)
  • Author(s): 山口寛二
  • Organizer: 第54回アメリカ肝臓学会
  • Place of Presentation: アメリカ、ボストン
  • Year and Date: 2009-11-02
• [Presentation] Inhibiting Interleukin-6/GP130 Signaling in Hepatocytes Worsens Hepatic Steatosis and Fibrosis in Lean and db/db mice Fed Methionine Choline Deficient Diets. (2008)
  • Author(s): Kanji Yamaguchi, Yoshito Itoh, Toshihisa Niimi, Norihiro Mitsuyoshi, Koichiro Yasui, Masahito Minami, Masaki Iwai, Okanoue Takeshi, Toshikazu Yoshikawa
  • Organizer: 第59回アメリカ肝臓病学会(ポスター)
  • Place of Presentation: サンフランシスコアメリカ
  • Year and Date: 2008-11-03
• [Presentation] マウス脂肪性肝炎モデルにおけるDGAT ASOの効果について (2008)
  • Author(s): 山口寛二、伊藤義人、横溝千尋、西村健、新美敏久、岡上武、吉川敏一
  • Organizer: 第44回日本肝臓学会総会ワークショップ
  • Place of Presentation: 愛媛
  • Year and Date: 2008-06-04