| Project/Area Number |
20790521
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa University |
|---|
Principal Investigator |
OKAJIMA Masaki Kanazawa University, 附属病院, 助教 (00361999)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
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| Keywords | ERストレス / 虚血再灌流 / 心筋梗塞 / シャペロン / シヤペロン |
|---|
| Research Abstract |
We assessed the hypothesis that 4-PBA (chemical chaperone) reduces endoplasmic reticulum stress (ER stress) mediated apoptosis and protects against myocardial ischemia-reperfusion injury or myocardial infarction in mice. In result, 4-PBA reduced ER stress mediated apoptosis, decreased infarct size, maintained cardiac function and improved survival ratio in mice with ischemia-reperfusion. On the other hand, 4-PBA inhibited fibrosis and induced cardiac rupture in mice with myocardial infarction.
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