| Project/Area Number |
20790538
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
SUGIMOTO Koichi Fukushima Medical University, 医学部, 助教 (30404867)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 分子血管病態学 / シグナル伝達 / 動脈硬化 / 血管内皮機能不全 / 酸化LDL受容体 / マトリックスメタロプロテアーゼ |
|---|
| Research Abstract |
We provided a new evidence that LOX-1, which is a receptor for oxidized LDL, forms a complex with MT1-MMP and regulates RhoA and Rac1 activation as well as eNOS and NADPH oxidase activation and ROS generation induced by oxidized LDL in endothelial cells. These results were published in Cardiovascular Research.
|
