Investigation into the role of hypothalamic SIRT1 in regulating energy metabolism.

• Project/Area Number: 20790637
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Gunma University
• Principal Investigator: SASAKI Tsutomu Gunma University, 生体調節研究所, 助教 (50466687)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: SIRT1 / 視床下部 / 食欲 / Sirt1 / 糖尿病 / 脳・神経 / 生理学 / 嘉現制御

Research Abstract

Sirt1 links the energy availability status with cellular metabolism in peripheral organs. Insulin and leptin signaling regulate food intake in the arcuate nucleus of the hypothalamus. Sirt1 has been reported to improve insulin sensitivity in vitro, but the role of hypothalamic Sirt1 in regulating feeding has not been addressed. We found that hypothalamic Sirt1 protein level and stability is regulated by food intake. Forced expression of wild-type Sirt1 in the mediobasal hypothalamus suppressed hyperphagia and weight gain by suppressing the expression of the orexigenic neuropeptide AgRP.

Research Products

• [Journal Article] Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP (2010)
  • Author(s): 佐々木努, 金惠珍, 小林雅樹, 北村ゆかり, 橋本(横田)博美, 志内哲也, 箕越靖彦, 北村忠弘
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Journal Article] Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP (2010)
  • Author(s): 佐々木努
  • Journal Title: Endocrinology (in press)
  • Peer Reviewed
• [Presentation] Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP (2010)
  • Author(s): 佐々木努
  • Organizer: 第14回国際内分泌学会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-03-30
• [Presentation] Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP (2010)
  • Author(s): 佐々木努
  • Organizer: 第14回国際内分泌学会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-03-30
• [Presentation] Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明 (2009)
  • Author(s): 佐々木努
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松(静岡県)
  • Year and Date: 2009-10-09
• [Presentation] Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明 (2009)
  • Author(s): 佐々木努
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2009-10-09
• [Presentation] Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明 (2009)
  • Author(s): 佐々木努
  • Organizer: 第82回日本内分泌学会
  • Place of Presentation: 前橋商工会議所(群馬県)
  • Year and Date: 2009-04-23
• [Presentation] Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明 (2009)
  • Author(s): 佐々木努
  • Organizer: 第82回日本内分泌学会
  • Place of Presentation: 前橋商工会議所
  • Year and Date: 2009-04-23