In vivo characterization of B cells with lymphoma-specific translocat in mice and their potential roles in lymphoma development.
| Project/Area Number |
20790673
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NISHIKORI Momoko Kyoto University, 医学研究科, 助教 (60378635)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 染色体転座 / BCL2 / 悪性リンパ腫 |
|---|
| Research Abstract |
To clarify how the BCL2/IGH translocation contributes to the development of lymphoma of germinal center B-cell origin, we used chimeric mouse models to examine the biological features of BCL2-overexpressing B cells. These cells showed a cell-autonomous differentiation preference for follicular B cells, and they have reduced responsiveness to terminal differentiation stimulation. We hypothesize that B cells that have undergone BCL2/IGH translocation might possibly be forced to localize in follicles, and accumulate genetic abnormalities by being subjected to recurrent stimulation.
|
Report
(3 results)
Research Products
(19 results)
