Investigation into the apoptotic signal of lymphocyte via Siva-1
| Project/Area Number |
20790678
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
SHIMODA Haruko University of Miyazaki, 医学部, 医員 (10452921)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 血液腫瘍学 / アポトーシス / インターフェロンα / 抗腫瘍作用 / シグナル伝達 / リンパ球 / サイトカイン |
|---|
| Research Abstract |
Tyk2 is essential for B cell growth inhibition by IFN-α. We found that Tyk2 interacts with and phosphorylates Siva-1. Siva-1 is a proapoptotic protein, and the interaction between Tyk2 and Siva-1 augmented Siva-1-induced apoptosis in Ba/F3 cells (murine pro-B cells). These observations suggest that Siva-1 forms a functional complex with Tyk2 and participates in the transduction of apoptotic signals of lymphocyte.
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Report
(3 results)
Research Products
(26 results)
