A novel cell-based functional diagnosis for the patients with mitochondrial disorders
| Project/Area Number |
20790760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
HATAKEYAMA Hideyuki National Center of Neurology and Psychiatry, 神経研究所疾病研究第二部, 流動研究員 (70466225)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ミトコンドリア病 / 患者由来培養細胞 / 生化学診断 / 綱羅的・体系的機能診断 / 患者組織由来細胞 / 生化学的機能解析 / ミトコンドリア生合成系 |
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| Research Abstract |
I established the methodology to characterize the phenotypic differences in the patients with mitochondrial diseases by using a systematic molecular and protein analysis in mitochondrial electron transport components and a comprehensive functional analysis in mitochondria and cells. This methodology would be available not only for investigating the actual molecular pathogenesis in various mitochondrial diseases caused by newly found mutations, but also for applications in evidence-based therapeutics according to the pathogenic features and the clinical symptoms of the patients.
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Report
(3 results)
Research Products
(14 results)
