Functional analysis of regulatory T cells in patient of drug hypersensitivity syndrome

• Project/Area Number: 20790815
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyorin University
• Principal Investigator: TAKAHASHI Ryo Kyorin University, 医学部, 助教 (00317091)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 皮膚炎症 / 再生学 / regulatory T cell / DIHS / SJS / ホーミング / 皮膚免疫

Research Abstract

We investigated whether regulatory T cells (Treg cells) associated with the pathogenesis of severe drug eruptions. We have fined that the number of Treg cells and the expression of skin-homing receptors on Treg cells was significantly different between Drug-induced Hypersensitivity Syndrome (DIHS) and Stevens-Johnson Syndrome (SJS).

Research Products

• [Journal Article] 重症薬疹とレギュラトリーT細胞 (2010)
  • Author(s): 高橋良
  • Journal Title: 臨床免疫・アレルギー科 54巻1号(投稿中)
  • NAID: 40017263521
• [Journal Article] Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome (2009)
  • Author(s): Takahashi R, Kano Y, Yamazaki Y, Kimishima M, Mizukawa Y, Shiohara T
  • Journal Title: The Journal of Immunology 182 Pages: 8071-79
  • Peer Reviewed
• [Journal Article] Current concepts on the diagnosis and pathogenesis of drug-induced hypersensitivity syndrome (2009)
  • Author(s): Shiohara T, Kano Y, Takahashi R
  • Journal Title: JMAJ 52 Pages: 347-352
  • Peer Reviewed
• [Journal Article] Defective Regulatory T Cells In Patients with Severe Drug Eruptions : Timing of the Dysfunction Is Associated with the Pathological Phenotype and Outcome (2009)
  • Author(s): Ryo Takahashi, Yoko Kano, Yoshimi Yamazaki, Momoko Kimishima, Yoshiko Mizukawa, Tetsuo Shiohara
  • Journal Title: The Journal of Immunology 182 Pages: 8071-8079
  • Peer Reviewed
• [Journal Article] Fucosyltransferase VII positive, skin?homing T cells in the blood and skin lesions of atopic dermatitis patients (2008)
  • Author(s): Mizukawa Y, Takahashi R, Yamazaki Y, Kimishima Mand Shiohara T
  • Journal Title: Exp.Dermatol 17 Pages: 170-176
  • Peer Reviewed
• [Presentation] Update on regulators: regulatory T cells in DIHS/DRESS and SJS/TEN. (2008)
  • Author(s): Shiohara T, Kano Y, Takahashi R
  • Organizer: 3rd International drug hypersensitivity meeting
  • Place of Presentation: Paris
  • Year and Date: 2008-04-12
• [Presentation] Association between drug and human herpesvirus in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms. (2008)
  • Author(s): Kano Y, Hirahara K, Asano Y, Mitsuyama Y, Takahashi R, Shiohara T
  • Organizer: 3rd International drug hypersensitivity meeting
  • Place of Presentation: Paris
  • Year and Date: 2008-04-12
• [Presentation] Trafficking receptor expression on regulatory t cells in severe drug eruptions (2008)
  • Author(s): Takahashi R, Shiohara T
  • Organizer: DHM3
  • Place of Presentation: Paris, France
• [Presentation] Severe drug hypersensitivity disorders is induced by dysfunctional Tregs (2008)
  • Author(s): Takahashi R, Kimisima M, Yamazaki Y, Shiohara T
  • Organizer: The International Investigative Dermatology 2008
  • Place of Presentation: Kyoto
• [Presentation] Trafficking receptor expression on regulatory t cells in severe drug eruptions (2008)
  • Author(s): Takahashi R, et.al.
  • Organizer: 3rd International drug hypersensitivity meeting (DHM3)
  • Place of Presentation: Paris. France
• [Presentation] Severe drug hypersensitivity disorders is induced by dysfunctional Tregs (2008)
  • Author(s): Takahashi R, et.al.
  • Organizer: The International Investigative Dermat ology 2008
  • Place of Presentation: Kyoto
• [Book] Pathomechanisms of lichen planus. Autoimmunity elicited by cross-reactive T cells. In Current Directions in Autoimmunity : DermatoloEic Autoimmunity (2008)
  • Author(s): Shiohara T, Mizukawa Y, Takahashi R. and Kano Y
  • Total Pages: 381
  • Publisher: Karger Press