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Self-monitoring dysfunction in schizophrenia using event related potential studies

Research Project

Project/Area Number 20790832
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

ARAKI Tsuyoshi  The University of Tokyo, 医学部・附属病院, 講師 (00456120)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords統合失調症 / 事象関連電位 / 脳波 / セルフモニタリン
Research Abstract

Self monitoring dysfunction in schizophrenia was investigated in this study using event related potentials. The auditory mismatch negativity task was employed and subjects including both patients with schizophrenia and normal controls were participated in this study. The grand mean event related potential waves showed relatively reduced in first episode schizophrenia compared with normal controls but there is no significant difference between groups. Patients with chronic schizophrenia showed reduced MMN and that would suggest that MMN could be one of the biological markers to reflect the progressive change in schizophrenia. We still continue further studies including the longitudinal studies and intra-cranial recording EEG studis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2009

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Association study between auditory P3a/P3b event-related potentials and thought disorder in schizophrenia2009

    • Author(s)
      Kirihara K, Araki T, Uetsuki M, Yamasue H, Hata A, Rogers MA, Iwanami A, Kasai K
    • Journal Title

      Brain Imaging and Behavior Volume3

      Pages: 277-283

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症における顔認知障害:事象関連電位研究2009

    • Author(s)
      切原賢治、荒木剛、笠井清登
    • Journal Title

      脳と精神の医学 第20巻

      Pages: 207-211

    • NAID

      10028262335

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] 統合失調症のグルタミン酸・GABA伝達異常2009

    • Author(s)
      切原賢治、荒木剛、神出誠一郎、笠井清登
    • Journal Title

      医学のあゆみ 第231巻

      Pages: 1040-1044

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] P300応用精神科の立場から2009

    • Author(s)
      切原賢治、荒木剛、笠井清登
    • Journal Title

      臨床神経生理学 第37巻

      Pages: 115-120

    • NAID

      10027056462

    • Related Report
      2009 Final Research Report
  • [Journal Article] Association study between auditory P3a/P3b event-related potentials and thought disorder in schizophrenia2009

    • Author(s)
      Kirihara K, Araki T, Uetsuki M, Yamasue H, Hata A, Rogers MA, Iwanami A, Kasai K
    • Journal Title

      Brain Imaging and Behavior Volume 3

      Pages: 277-283

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P300応用 精神科の立場から2009

    • Author(s)
      切原賢治、荒木剛、笠井清登
    • Journal Title

      臨床神経生理学 第37巻

      Pages: 115-120

    • NAID

      10027056462

    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症の早期介入マーカーとしてのMMN2009

    • Author(s)
      荒木剛、笠井清登
    • Organizer
      第39回日本臨床神経生理学会シンポジウム
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 統合失調症の早期介入マーカーとしてのMMN2009

    • Author(s)
      荒木剛、笠井清登
    • Organizer
      第39回日本臨床神経生理学会 シンポジウム
    • Place of Presentation
      北九州
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症の早期介入マーカーとしての事象関連電位2009

    • Author(s)
      荒木剛、笠井清登
    • Organizer
      第37回日本精神科病院協会精神医学会シンポジウム
    • Place of Presentation
      高松
    • Year and Date
      2009-11-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 統合失調症の早期介入マーカーとしての事象関連電位2009

    • Author(s)
      荒木剛、笠井清登
    • Organizer
      第37回日本精神科病院協会精神医学会 シンポジウム
    • Place of Presentation
      高松
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gamma band activity during gaze processing in schizophrenia2009

    • Author(s)
      Kirihara K, Araki T, Kawakubo Y, Onitsuka T, Kobayashi T, Kasai K
    • Organizer
      18th International Congress on Brain Electromagnetic Topography
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-10-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Gamma band activity during gaze processing in schizophrenia2009

    • Author(s)
      Kirihara K, Araki T, Kawakubo Y, Onitsuka T, Kobayashi T, Kasai K
    • Organizer
      18th International Congress on Brain Electromagnetic Topography
    • Place of Presentation
      京都
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] MEG mismatch abnormalities to speech sounds in schizophrenia: Heritability and relationship to genetics2009

    • Author(s)
      Araki T, Kasai K
    • Organizer
      9th World Congress of Biological Psychiatry
    • Place of Presentation
      Paris, France.
    • Year and Date
      2009-06-30
    • Related Report
      2009 Final Research Report
  • [Presentation] MEG mismatch abnormalities to speech sounds in schizophrenia : Heritability and relationship to genetics2009

    • Author(s)
      荒木剛, 笠井清登
    • Organizer
      9th World Congress of Biological Psychiatry(symposium)
    • Place of Presentation
      Paris, France
    • Year and Date
      2009-06-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] Go/ No-go課題遂行時の事象関連電位を用いた統合失調症における抑制機能障害の検討2009

    • Author(s)
      荒木剛、切原賢治、笠井清登
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Final Research Report
  • [Presentation] 事象関連電位を統合失調症の早期介入のマーカーとして応用する試みについて2009

    • Author(s)
      荒木剛、高野洋輔、小池進介、井上秀之、切原賢治、笠井清登
    • Organizer
      第31回日本生物学的精神医学会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Go/No-go課題遂行時の事象関連電位を用いた統合失調症における抑制機能障害の検討2009

    • Author(s)
      荒木剛、切原賢治、笠井清登
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 事象関連電位を統合失調症の早期介入のマーカーとして応用する試みについて2009

    • Author(s)
      荒木剛、高野洋輔、小池進介、井上秀之、切原賢治、笠井清登
    • Organizer
      第31回日本生物学的精神医学会 シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Book] 精神疾患と認知機能2009

    • Author(s)
      切原賢治、荒木剛、笠井清登
    • Publisher
      新興医学出版社
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Book] 精神医学を知る2009

    • Author(s)
      荒木剛、笠井清登
    • Publisher
      東京大学出版会
    • Related Report
      2009 Annual Research Report 2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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