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Explore of schizophrenia susceptible genes based on the findings in postmortem study

Research Project

Project/Area Number 20790838
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKobe University

Principal Investigator

FUKUTAKE Masaaki  Kobe University, 大学院・医学研究科, 助教 (80457085)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords統合失調症 / 自殺 / 相関研究 / 遺伝子多型 / SNP / ハプロタイプ / 死後脳 / meta-analysis / 相関 / NOS1 / DNA chip / tryptophan hydroxylase / セロトニン / tag SNP / kruppel-like factor 5
Research Abstract

Focusing on the biological vulnerability on which the pathogenesis of schizophrenia have been considered to be based, we have explored the genetic variants of schizophrenia susceptible genes. We have conducted association analysis of the interest genetic varints with schizophrenia based on the hypothesis such as the neurodevelopment model of schizophrenia. In addition, we have approached the subject from another perspective to identify the novel schizophrenia susceptible genetic variants using DNA microarray experiments to the postmortem study of schizophrenia, and based on the findings of the microarray analysis, we have conducted further association analysis. As a result, we have identified several important genetic variants associated with schizophrenia.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (42 results)

All 2011 2010 2009 2008

All Journal Article (27 results) (of which Peer Reviewed: 26 results) Presentation (12 results) Book (3 results)

  • [Journal Article] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.2011

    • Author(s)
      Supriyanto I, Sasada T, Fukutake M, Asano M, Ueno Y, Nagasaki Y, Shirakawa O, Hishimoto A.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35(1)

      Pages: 252-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population.2011

    • Author(s)
      Kyogoku C, Yanagi M, Nishimura K, Sugiyama D, Morinobu A, Fukutake M, Maeda K, Shirakawa O, Kuno T, Kumagai S.
    • Journal Title

      Psychiatry Res. 185(1-2)

      Pages: 16-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain2011

    • Author(s)
      Cui H, et al
    • Journal Title

      Schizophr Res

      Volume: 121(1-3) Pages: 172-178

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population2011

    • Author(s)
      Supriyanto I, et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35(1) Pages: 252-256

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population2011

    • Author(s)
      Kyogoku C, et al
    • Journal Title

      Psychiatry Res

      Volume: 185(1-2) Pages: 16-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of EP1 gene polymorphisms with suicide completers in the Japanese population.2010

    • Author(s)
      Cui H, Supriyanto I, Sasada T, Shiroiwa K, Fukutake M, Shirakawa O, Asano M, Ueno Y, Nagasaki Y, Hishimoto A.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. [Epub ahead of print]

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of RGS2 gene polymorphisms with panic disorder in Japanese.2010

    • Author(s)
      Mouri K, Hishimoto A, Fukutake M, Nishiguchi N, Shirakawa O, Maeda K.
    • Journal Title

      Kobe J Med Sci. 55(5)

    • NAID

      110007614321

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain.2010

    • Author(s)
      Cui H, Nishiguchi N, Yanagi M, Fukutake M, Mouri K, Kitamura N, Hashimoto T, Shirakawa O, Hishimoto A.
    • Journal Title

      Schizophr Res. 121(1-3)

      Pages: 172-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population.2010

    • Author(s)
      Shiroiwa K, Hishimoto A, Mouri K, Fukutake M, Supriyanto I, Nishiguchi N, Shirakawa O.
    • Journal Title

      Neurosci Lett. 472(3)

      Pages: 194-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide : a preliminary observation in the Japanese male population.2010

    • Author(s)
      Hishimoto A, Fukutake M, Mouri K, Nagasaki Y, Asano M, Ueno Y, Nishiguchi N, Shirakawa O.
    • Journal Title

      Genes Brain Behav 9(5)

      Pages: 498-502

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的視点からみた自殺2010

    • Author(s)
      福武将映、白川治
    • Journal Title

      自殺予防と危機介入 第30巻第1号

      Pages: 84-91

    • NAID

      40017072744

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的視点からみた自殺2010

    • Author(s)
      福武将映, ら
    • Journal Title

      自殺予防と危機介入

      Volume: 30(1) Pages: 84-91

    • NAID

      40017072744

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Common genetic variations in TPH1/ TPH2 genes are not associated with schizophrenia in Javanese population.2010

    • Author(s)
      Shiroiwa K, et al
    • Journal Title

      Neurosci Lett Epub

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide ; A preliminary observation in the Japanese male population.2010

    • Author(s)
      Hishimoto A, et al
    • Journal Title

      Genes Brain Behav Epub

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Study of RGS2 Gene Polymorphisms with Panic Disorder in Japanese.2010

    • Author(s)
      Mouri K, et al
    • Journal Title

      Kobe Journal of Medical Sciences (in press)(掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TPH2 is not a susceptibility gene for suicide in Japanese population.2009

    • Author(s)
      Mouri K, Hishimoto A, Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 33(8)

      Pages: 1546-50

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scale for measuring self-recoverability in daily life for people with schizophrenia.2009

    • Author(s)
      Takamatsu T, Hashimoto T, Taira M, Fukutake M, Maeda K.
    • Journal Title

      Psychiatry Clin Neurosci. 63(3)

      Pages: 277-82

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 精神科外来における統合失調症患者に対するblonanserinの使用経験2009

    • Author(s)
      菱本明豊、福武将映、山本泰司、毛利健太朗、白岩恭一、田中究、青山慎介、前田潔
    • Journal Title

      臨床精神薬理 12(9)

      Pages: 1999-2009

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TPH2 is not a susceptibility gene for suicide in Japanese population.2009

    • Author(s)
      Mouri K, et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 33(8)

      Pages: 1546-1550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Species differences in cannabinoid receptor 2 (CNR2 gene) : identificatiot of novel human and rodent CB2 isoforms, differential tissue expression, and regulation by cannabinoid receptor ligands.2009

    • Author(s)
      Qing-Rong Liu, et al
    • Journal Title

      Genes Brain Behav 8(5)

      Pages: 512-530

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神科外来における統合失調症患者に対するblonanserinの使用経験2009

    • Author(s)
      菱本明豊, ら
    • Journal Title

      臨床精神薬理誌 12(9)

      Pages: 1999-2009

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females.2008

    • Author(s)
      Fukutake M, Hishimoto A, Nishiguchi N, Nushida H, Ueno Y, Shirakawa O, Maeda K.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 32(6)

      Pages: 1428-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia.2008

    • Author(s)
      Yanagi M, Hashimoto T, Kitamura N, Fukutake M, Komure O, Nishiguchi N, Kawamata T, Maeda K, Shirakawa O.
    • Journal Title

      Schizophr Res. 100(1-3)

      Pages: 291-301

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims.2008

    • Author(s)
      Cui H, Nishiguchi N, Ivleva E, Yanagi M, Fukutake M, Nushida H, Ueno Y, Kitamura N, Maeda K, Shirakawa O.
    • Journal Title

      Neuropsychopharmacology 33(7)

      Pages: 1537-44

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females2008

    • Author(s)
      Fukutake M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 32

      Pages: 1428-1433

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizoohrenia2008

    • Author(s)
      Yanagi M
    • Journal Title

      Schizophrenia Research 100

      Pages: 291-301

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of RGS2 gene polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims2008

    • Author(s)
      Cui H
    • Journal Title

      Neuropsychopharmacology 33

      Pages: 1537-1544

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.2011

    • Author(s)
      Hishimoto A, Sasada T, Fukutake M, Shiroiwa K, Supriyanto I, Shirakawa O.
    • Organizer
      The 18th European Congress of Psychiatry
    • Place of Presentation
      Vienna(Austria)
    • Year and Date
      2011-03-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 自殺とBDNF遺伝子多型との相関研究2010

    • Author(s)
      吉田正邦, ら
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県)
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経型一酸化窒素合成酵素(NOS1)遺伝子のシス活性を持つ一塩基多型は死後脳NOS1免疫反応レベルと統合失調症に相関する2010

    • Author(s)
      菱本明豊、福武将映, 他
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経型一酸化窒素合成酵素(NOS1)遺伝子のシス活性を持つ一塩基多型は死後脳NOS1免疫反応レベルと統合失調症に相関する2010

    • Author(s)
      菱本明豊, ら
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide2010

    • Author(s)
      Hishimoto A, et al
    • Organizer
      the 18th European Congress of Psychiatry
    • Place of Presentation
      Munich (Germany)
    • Year and Date
      2010-02-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 精神科外来における統合失調症患者に対するblonanserinの使用経験2009

    • Author(s)
      福武将映, その他
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 精神科外来における統合失調症患者に対するblonanserinの使用経験2009

    • Author(s)
      福武将映, ら
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neurobiology of suicide2009

    • Author(s)
      Maeda K, et al
    • Organizer
      The Kobe Conference of Neuropsychiatric Association
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] RGS2遺伝子多型とパニック障害との相関研究2009

    • Author(s)
      毛利健太朗、福武将映, 他
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] RGS2遺伝子多型とパニック障害との相関研究2009

    • Author(s)
      毛利健太朗, ら
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 自殺とNOS3遺伝子多型との相関研究2008

    • Author(s)
      毛利健太郎, ら
    • Organizer
      第30回日本生物学的精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自殺とNOS1遺伝子多型との相関研究2008

    • Author(s)
      白岩恭一, ら
    • Organizer
      第30回日本生物学的精神医学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Book] 専門医のための精神科臨床リュミエール29自殺予防の基本戦略III2011

    • Author(s)
      福武将映、菱本明豊、白川治、中山書店
    • Publisher
      自殺の生物学的知見
    • Related Report
      2010 Final Research Report
  • [Book] 専門医のための精神科臨床リュミエール29自殺予防の基本戦略2011

    • Author(s)
      福武将映, ら
    • Total Pages
      244
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 統合失調症の再発再燃例へのプロナンセリンの効果(プロナンセリン100の症例)2009

    • Author(s)
      菱本明豊, ら
    • Total Pages
      317
    • Publisher
      星和書店
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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