Explore of schizophrenia susceptible genes based on the findings in postmortem study
| Project/Area Number |
20790838
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kobe University |
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Principal Investigator |
FUKUTAKE Masaaki Kobe University, 大学院・医学研究科, 助教 (80457085)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 統合失調症 / 自殺 / 相関研究 / 遺伝子多型 / SNP / ハプロタイプ / 死後脳 / meta-analysis / 相関 / NOS1 / DNA chip / tryptophan hydroxylase / セロトニン / tag SNP / kruppel-like factor 5 |
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| Research Abstract |
Focusing on the biological vulnerability on which the pathogenesis of schizophrenia have been considered to be based, we have explored the genetic variants of schizophrenia susceptible genes. We have conducted association analysis of the interest genetic varints with schizophrenia based on the hypothesis such as the neurodevelopment model of schizophrenia. In addition, we have approached the subject from another perspective to identify the novel schizophrenia susceptible genetic variants using DNA microarray experiments to the postmortem study of schizophrenia, and based on the findings of the microarray analysis, we have conducted further association analysis. As a result, we have identified several important genetic variants associated with schizophrenia.
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Report
(4 results)
Research Products
(42 results)
