Role of splicing factors in the pathogenesis of mood disorders
Project/Area Number |
20790844
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Yamaguchi University |
Principal Investigator |
UCHIDA Shusaku Yamaguchi University, 大学院・医学系研究科, 助教 (10403669)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 気分障害 / 選択的スプライシング / 遺伝子発現 / 撰択的スプライシング |
Research Abstract |
In this study, we examined the expression analyses of genes which are involved in the regulation of splicing and transcription in mood disorder patients. We found that the expression of SRp20, nPTB, and HDACs mRNAs were altered in patients with mood disorders. Thus our results suggest the aberrant regulations of alternative splicing and transcription in mood disorder.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Characterization of the vulnerability to repeated restraint stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor.2008
Author(s)
Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y.
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Journal Title
European Journal of Neuroscience 27
Pages: 2250-2261
Related Report
Peer Reviewed
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