Correlation of cell surface antigens with individual differences in radiosensitivity in human hematopoietic stem/progenitor cells.

• Project/Area Number: 20790874
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Hirosaki University
• Principal Investigator: TAKAHASHI Kenji Hirosaki University, 大学院・保健学研究科, 助教 (00400143)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 放射線 / 細胞・組織 / 再生医学シグナル伝達 / 生体分子 / 再生医学 / シグナル伝達

Research Abstract

To characterize the differences in the radiosensitivity of individual populations of human hematopoietic stem/progenitor cells, we examined the relationship among cell surface antigens, clonogenic potential and radiation survival.

Research Products

• [Journal Article] Correlations of cell surface antigens with individual differences in radiosensitivity in human hematopoietic stem/progenitor cells. (2010)
  • Author(s): Takahashi K., Monzen S., Hayashi N., Kashiwakura I.
  • Journal Title: Radiation Research 173 Pages: 184-190
  • NAID: 130007000549
  • Peer Reviewed
• [Journal Article] Radiation sensitivities in the terminal stages of megakaryocytic maturation and platelet production. (2010)
  • Author(s): Monzen S., Takahashi K., Kashiwakura I. (6名中5番目)
  • Journal Title: Radiation Research 172 Pages: 314-320
  • Peer Reviewed
• [Journal Article] Correlations of cell surface antigens with individual differences in radio sensitivity in human hematopoietic stem/progenitor cells (2010)
  • Author(s): Takahashi K
  • Journal Title: Radiation research 173 Pages: 184-190
  • NAID: 130007000549
  • Peer Reviewed
• [Journal Article] Effects of proteoglycan extracted from nasal cartilage of salmon heads on maturation of dendritic cells derived from human peripheral blood monocytes (2010)
  • Author(s): Yoshino H
  • Journal Title: Biological and pharmaceutical bulletin 33 Pages: 311-315
  • Peer Reviewed
• [Journal Article] Heavy ion beam irradiation regulates the mRNA expression in megakar yocytopoiesis from human hematopoietic stem/progenitor cells (2009)
  • Author(s): Monzen S
  • Journal Title: Journal of radiation research 50 Pages: 477-486
  • Peer Reviewed
• [Journal Article] Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells.
  • Author(s): Kato K., Takahashi K., Kashiwakura I. (7名中2番目)
  • Journal Title: Radiation Research (印刷中)
  • Peer Reviewed
• [Presentation] ヒト造血幹細胞の放射線感受性における酸化ストレス応答機構の関与 (2009)
  • Author(s): 加藤健吾
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
• [Presentation] Effects of LET-radiation on human megakaryocytopoiesis and thrombopoiesis. (2009)
  • Author(s): Takahashi K.
  • Organizer: ISEH 37th Annual Scientific Meeting
  • Place of Presentation: Boston, USA