Cytoskeletal rearrangement of neutrophils after one-lung ventilation
| Project/Area Number |
20790983
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
EGUCHI Takashi Shinshu University, 医学部附属病院, 医員 (50447744)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 片肺換気 / 虚血再潅流障害 / 好中球 / 細胞骨格 / シベレスタット |
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| Research Abstract |
Re-expansion following one-lung ventilation (OLV) leads to neutrophil recruitment into the lung and causes alveolar damage. The morphological and functional behaviors of neutrophils that are associated with OLV have not been thoroughly elucidated. Our study shows that lung re-expansion following OLV induces cytoskeletal rearrangements in circulating neutrophils and promotes their capillary sequestration and migration, particularly in the ventilated lung. Blockade of neutrophil elastase by sivelestat inhibits these events and improves pulmonary oxygenation.
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Report
(3 results)
Research Products
(8 results)
