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Alternative Therapeutic Strategy for Aortic Aneurysm Using Rapping Technique and Drug (Doxycycline) Delivery System

Research Project

Project/Area Number 20790986
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNagoya University

Principal Investigator

TADAHITO Eda  Nagoya University, 医学部・附属病院, 病院助教 (70467299)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords大動脈瘤 / 低侵襲手術 / ドラッグデリバリーシステム(DDS) / doxycycline / pitavastatin
Research Abstract

Surgery for aortic aneurysm (AA) has still high mortality rate. Therefore, alternative therapeutic strategy is awaited. Meanwhile, doxycycline (DOXY) has capability of progression of AA. In this study, we demonstrated the possibility of local administration of DOXY using DOXY controlled releasing biodegradable fiber (DCRBF) for AA. DCRBF was fabricated using electrospinning technique. We evaluated expression of proteases, elastin and inflammatory markers from SMCs, macrophages and aortic tissue co-cultured with or without DCRBF. DCRBF was administrated to in vivo AA which was induced apolipoprotein E deficient mice. In the presence of DCRBF, elastin content was preserved, and expression of proteases, inflammatory markers was reduced in vitro and in vivo. These results suggest that administration of DCRBF to AA may be promising alternative therapeutic strategy.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008

All Presentation (12 results)

  • [Presentation] 薬剤徐放性ファイバーを用いた大動脈瘤治療の可能性2010

    • Author(s)
      山脇藍歌、江田匡仁, 他
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 弓部大動脈手術の標準術式2010

    • Author(s)
      碓氷章彦、江田匡仁, 他
    • Organizer
      第40回日本心臓血管外科学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-02-15
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 大動脈瘤に対する新たな治療戦略 -ドキシサイクリン溶出担体の効果-2009

    • Author(s)
      江田匡仁, 他
    • Organizer
      第47回日本人工臓器学会大会
    • Place of Presentation
      新潟
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Alternative Therapeutic Strategy for Aortic Aneurysm Using Mesenchymal Stem Cells or Doxycicline Controlled Releasing Device.2009

    • Author(s)
      Eda T, et al.
    • Organizer
      2nd Tissue Engineering and Regenerative Medicine International Society World Congress
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2009-09-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Alternative Therapeutic Strategy for Aortic Aneurysm Using Mesenchym al Stem Cells or Doxycicline Controlled Releasing Device.2009

    • Author(s)
      Eda T, et al.
    • Organizer
      2nd Tissue Engineering and Regenerative Medicine International Society World Congress
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 間葉系幹細胞および薬剤溶出ナノファイバーを用いた大動脈瘤治療の可能性2009

    • Author(s)
      江田匡仁, 他
    • Organizer
      第8回日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ARとSVC症候群を呈した破裂製バルサルバ洞瘤の1例2008

    • Author(s)
      江田匡仁, 他
    • Organizer
      第5 1回関西胸部外科学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report
  • [Presentation] ARとSVC症候群を呈した破裂製バルサルバ洞瘤の1例2008

    • Author(s)
      江田匡仁, 他
    • Organizer
      第51回関西胸部外科学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 大動脈二尖弁に対するvalve sparing operation2008

    • Author(s)
      江田匡仁, 他
    • Organizer
      第5 1回関西胸部外科学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-06-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 特異な形態を呈したBentall術後仮性動脈瘤の1手術例2008

    • Author(s)
      江田匡仁, 他
    • Organizer
      第5 1回関西胸部外科学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-06-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 大動脈二尖弁に対するvalve sparing operation2008

    • Author(s)
      江田匡仁, 他
    • Organizer
      第51回関西胸部外科学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 特異な形態を呈したBentall術後仮性動脈瘤の1手術例2008

    • Author(s)
      江田匡仁, 他
    • Organizer
      第51回関西胸部外科学会学術集会
    • Place of Presentation
      富山
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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