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Chemokines in Aqueous humour before and after IntravitrealTriamcinolone Acetonide in Eyes with Macular Edema Associated with Branch Retinal VeinOcclusion

Research Project

Project/Area Number 20791243
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTohoku University

Principal Investigator

KUNIKATA Hiroshi  Tohoku University, 病院, 講師 (40361092)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsケモカイン / 前房水 / ステロイド / 黄斑浮腫 / 網膜静脈分枝閉塞 / MIP-1β / サイトカイン / 硝子体 / トリアムシノロンアセトニド / 中心窩網膜厚 / VEGF / トリアムシノロン / MIP-1b
Research Abstract

We determined the aqueous humour levels of chemokines before and after an intravitreal injection of triamcinolone acetonide (IVTA) in eyes with macular edema associated with a branch retinal vein occlusion (ME-BRVO). At the baseline, MCP-1 and MIP-1a were detected in the aqueous, and MIP-1b was significantly higher in eyes with a ME-BRVO than in controls. One week after IVTA, the foveal thickness (FT) was significantly decreased, and the levels of MCP-1 and MIP-1b were also significantly reduced. The decrease in the FT was correlated with the decrease of only MIP-1b. This indicates that the steroid-dependent ME-BRVO was closely related with the level of MIP-1b.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Visual outcome and complications of 25-gauge vitrectomy for rhegmatogenous retinal detachment2010

    • Author(s)
      Kunikata H, Nishida K.
    • Journal Title

      Eighty-four consecutive cases. Eye. (In press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokines in Aqueous humour before and after Intravitreal Triamcinolone Acetonide in Eyes with Macular Edema Associated with Branch Retinal Vein Occlusion.2010

    • Author(s)
      Kunikata H, Shimura M, Nakazawa T, Sonoda K, Yoshimura T, Ishibashi T, Nishida K.
    • Journal Title

      Acta Ophthalmologica. (In press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokines in Aqueous humour before and after Intravitreal Triamcinolone Acetonide in Eyes with Macular Edema Associated with Branch Retinal Vein Occlusion2010

    • Author(s)
      Kunikata H, Shimura M, Nakazawa T, Sonoda K, Yoshimura T, Ishibashi T, Nishida K.
    • Journal Title

      Acta Ophthalmologica (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual outcome and complications of 25-gauge vitrectomy for rheamatogenous retinal detachment ; Eighty-four consecutive cases2010

    • Author(s)
      Kunikata H, Nishida K.
    • Journal Title

      Eye (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central retinal artery occlusion following severe blow-out fracture in young adult.2009

    • Author(s)
      Himori N, Kunikata H, Otomo T, Fuse N, Nishida K.
    • Journal Title

      Clin Ophthalmol 3

      Pages: 325-328

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central retinal artery occlusion following severe blow-out fracture in young adult2009

    • Author(s)
      Himori N, Kunikata H, Otomo T, Fuse N, Nishida K.
    • Journal Title

      Clin Ophthalmol 3

      Pages: 325-328

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central Retinal Artery Occlusion followingSevere Blow-out Fracture in Young Adult2009

    • Author(s)
      Himori N, Kunikata K, Otomo T, MD. Fuse N and Nishida K
    • Journal Title

      Clin Ophthalmol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitreous levels of vasohibin-1 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy2009

    • Author(s)
      Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta H, Sonoda H. Sato Y, Nishida K
    • Journal Title

      Diabetologia 52

      Pages: 359-361

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Vasohibin, an Antiangiogenic Factor, in Human Choroidal Neovascular Membranes2008

    • Author(s)
      Wakusawa R, Abe T, Sato H, Yosh ida M, Kunikata H, Sato Y, Nish ida K
    • Journal Title

      Am J Ophthalmol 146

      Pages: 235-243

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual prognosis and vitreous cytokine levels after arteriovenous she athotomy in branch retinal vein occlusion associated with macular oed ema2008

    • Author(s)
      Shimura M, Nakazawa T, Yasuda K , Kunikata H, Shiono T, Nishida K
    • Journal Title

      Acta Ophthalmol Scand 86

      Pages: 377-384

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 裂孔原性網膜剥離2009

    • Author(s)
      國方彦志
    • Organizer
      Nagoya Ophthalmic Week 2009日本網膜硝子体学会2
    • Place of Presentation
      名古屋
    • Year and Date
      2009-12-06
    • Related Report
      2009 Final Research Report
  • [Presentation] シンポジウム4スモールゲージ手術での進化「裂孔原性網膜剥離」2009

    • Author(s)
      國方彦志
    • Organizer
      第48回日本網膜硝子体学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 黄斑前膜に対する25ゲージ手術後の眼圧変化2009

    • Author(s)
      國方彦志、西田幸二
    • Organizer
      日本眼科手術学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 特発性黄斑上膜に対する25ゲージ硝子体手術後の視力予後に関与する因子2009

    • Author(s)
      國方彦志、鬼怒川次郎、宮澤弘史、阿部俊明、西田幸二
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-10
    • Related Report
      2009 Final Research Report
  • [Presentation] 黄斑前膜に対する25ゲージ硝子体手術後の眼圧変化2009

    • Author(s)
      國方彦志
    • Organizer
      第47回日本眼科手術学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-01-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 25ゲージ硝子体手術後の重篤な脈絡膜剥離2008

    • Author(s)
      國方彦志、高橋秀肇、中村政彦、西田幸二
    • Organizer
      日本網膜硝子体学会
    • Place of Presentation
      京都
    • Year and Date
      2008-11-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 25ゲージ硝子体手術後の重篤な脈絡膜剥離2008

    • Author(s)
      國方彦志
    • Organizer
      第47回日本眼科手術学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 黄斑前膜に対する25ゲージ硝子体手術成績2008

    • Author(s)
      國方彦志、鬼怒川次郎、大友孝昭、西郷陽子、涌澤亮介、宮澤弘史、阿部俊明、西田幸二
    • Organizer
      日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-23
    • Related Report
      2009 Final Research Report
  • [Presentation] 黄斑前膜に対する25ゲージ硝子体手術成績2008

    • Author(s)
      國方彦志
    • Organizer
      第62回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Book] 眼科研修ノート2009

    • Author(s)
      國方彦志, ほか
    • Publisher
      診断と治療社
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Book] 眼科研修医ノート2009

    • Author(s)
      永井良三, ほか
    • Total Pages
      532
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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