burn and immunity : the role of alarmin from burn wound
| Project/Area Number |
20791329
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
MORIZANE Ruri Aichi Medical University, 医学部, 助教 (30465520)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 熱傷 / サイトカイン / アラーミン / アデノシン / HMGB1 / alarmin / PAI-1 / DAMPs / 重症熱傷 / 焼痂 / 脾細胞 |
|---|
| Research Abstract |
An adenosine known as one of the alarmin has a strong anti-inflammatory action. Adenosine inhibits inflammatory cytokine production from monocytes at at μM level. We found that serum adenosine level increased significantly under condition of massive tissue injury like burn. We suggest that released adenosine from injured tissue would have physiological role to regulate excessive inflammation at site of burn wound.
|
Report
(3 results)
Research Products
(3 results)
