Group A streptococci translocates across epithelial barrier via intercellular junction cleavage
| Project/Area Number |
20791336
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
SUMITOMO Tomoko Osaka University, 大学院・歯学研究科, 助教 (50423421)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | レンサ球菌 / 病原因子 / 組織侵入 / 細胞間隙 / 上皮バリア |
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| Research Abstract |
Group A Streptococcus pyogenes (GAS) is a human pathogen that causes local suppurative infections and severe invasive diseases. Systemic dissemination of GAS is initiated by bacterial penetration of the epithelial barrier of the pharynx or damaged skin. In this study, our data indicate a potential function of Streptolysin S that facilitates GAS invasion into deeper tissue via degradation of epithelial intercellular junctions in concert with the host cysteine protease calpain.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion2010
Author(s)
Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.
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Journal Title
Biochem Biophys Res Commun 391(2)
Pages: 1192-1196
Related Report
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[Journal Article] Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49.2009
Author(s)
Nakata M, Koller T, Moritz K, Ribardo D, Jonas L, McIver KS, Sumitomo T, Terao Y, Kawabata S, Podbielski A, Kreikemeyer B.
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Journal Title
Infect Immun 77(1)
Pages: 32-44
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